Research Report
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2019
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academic article
- 1¿(2¿,5¿-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1- propanone (RGM079): A Positive Allosteric Modulator of ¿7 Nicotinic Receptors with Analgesic and Neuroprotective Activity
- A Novel Agonist of the Type 1 Lysophosphatidic Acid Receptor (LPA1), UCM-05194, Shows Efficacy in Neuropathic Pain Amelioration.
- A positive allosteric modulator of alpha7 nicotinic receptors with analgesic and neuroprotective activity.
- Accessibility of Cations to the Selectivity Filter of Kcsa in the Inactivated State: An Equilibrium Binding Study
- Acute phase protein response to viral infection and vaccination
- Antioxidant and Photoprotective Activity of Apigenin and its Potassium Salt Derivative in Human Keratinocytes and Absorption in Caco-2 Cell Monolayers
- Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion
- CSF-ApoER2 fragments as a read-out of reelin signaling: Distinct patterns in sporadic and autosomal-dominant Alzheimer disease.
- Characterization of cerebrospinal fluid BACE1 species
- DNA methylation profile of different clones of human adipose stem cells does not allow to predict their differentiation potential.
- Development of a New Delivery System Based on Drug-Loadable Electrospun Nanofibers for Psoriasis Treatment
- Differential effects of a combination of Hibiscus sabdariffa and Lippia citriodora polyphenols in overweight/obese subjects: A randomized controlled trial
- Epigallocatechin-3-gallate location and interaction with late endosomal and plasma membrane model membranes by molecular dynamics.
- Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits
- Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.
- Fish Red Blood Cells Modulate Immune Genes in Response to Bacterial Inclusion Bodies Made of TNF¿ and a G-VHSV Fragment
- Glutathione-dependent enzyme activities of peripheral blood mononuclear cells decrease during the winter season compared with the summer in normal-weight and severely obese adolescents
- Homo-FRET studies of potassium channel KcsA: a closer look to selectivity filter dynamics and regulation
- Hydroxycholesterol binds and enhances the anti-viral activities of zebrafish monomeric c-reactive protein isoforms
- IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.
- Integrated Transcriptomic and Proteomic Analysis of Red Blood Cells from Rainbow Trout Challenged with VHSV Point Towards Novel Immunomodulant Targets
- Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers.
- Marine Invertebrate Extracts Induce Colon Cancer Cell Death via ROS-Mediated DNA Oxidative Damage and Mitochondrial Impairment
- Measurement of CSF alpha-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.
- Mechanisms of blockade of the muscle-type nicotinic receptor by benzocaine, a permanently uncharged local anesthetic
- Metabolomic analysis of the effects of a commercial complex biostimulant on pepper crops
- Modulation of the KcsA potassium channel by anionic phospholipids: Role of the non-annular arginines
- Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells
- Overexpression of P2X3 and P2X7 Receptors and TRPV1 Channels in Adrenomedullary Chromaffin Cells in a Rat Model of Neuropathic Pain.
- Plasma proteomic analysis of zebrafish following spring viremia of carp virus infection
- Potential Role of Rainbow Trout Erythrocytes as Mediators in the Immune Response Induced by a DNA Vaccine in Fish.
- Pre-analytical stability of novel cerebrospinal fluid biomarkers
- Preclinical evaluation of the antimicrobial-immunomodulatory dual action of xenohormetic molecules against Haemophilus influenzae respiratory infection
- Rainbow Trout Red Blood Cells Exposed to Viral Hemorrhagic Septicemia Virus Up-Regulate Antigen-Processing Mechanisms and MHC I&II, CD86, and CD83 Antigen-presenting Cell Markers.
- Relationships Between Chemical Structure and Antioxidant Activity of Isolated Phytocompounds from Lemon Verbena
- Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity.
- Revisiting silibinin as a novobiocin-like Hsp90¿C-terminal inhibitor: Computational modeling and experimental validation.
- Structure-based design of novel biphenyl amide antagonists of human Transient Receptor Potential Cation Channel Subfamily M Member 8 channels (TRPM8) with potential implications in the treatment of sensory neuropathies.
- The Megalocytivirus RBIV Induces Apoptosis and MHC Class I Presentation in Rock Bream (Oplegnathus fasciatus) Red Blood Cells
- The Potential Synergistic Modulation of AMPK by Lippia citriodora Compounds as a Target in Metabolic Disorders
- The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3
- The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase.
- The metabolic and vascular protective effects of olive (Olea europaea L.) leaf extract in diet-induced obesity in mice are related to the amelioration of gut microbiota dysbiosis and to its immunomodulatory properties.
- The prebiotic properties of Hibiscus sabdariffa extract contribute to the beneficial effects in diet-induced obesity in mice
- Viral interference between infectious pancreatic necrosis virus and spring viremia of carp virus in zebrafish
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book
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chapter
- Evaluation of the degree of student satisfaction
- Fluorescence-Based Functional Assays for Ca2+-Permeable ThermoTRP Channels
- Implementation of new teaching innovation tools in the biotechnology degree from the UMH: Evaluation of the degree of impact on academic perfomance
- In Silico Approaches for TRP Channel Modulation
- UV Exposure and Skin Protective Effects of Plant Polyphenols.
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congress communication
- In vitro characterization of a TRPV1 soft antagonist.
- In vitro characterization of a TRPV1 soft antagonist.
- In vitro characterization of a TRPV1 soft antagonist.
- Potential role of rainbow trout red blood cells as mediators in the immune response induced by DNA vaccines
- A capsaicin-based TRPV1 soft antagonist as an anti-pruritic drug candidate
- A capsaicin-based TRPV1 soft antagonist as an anti-pruritic drug candidate.
- A new family of chiral heterocyclic compounds that blocks the TRPM8 activation.
- A nudibrnach extract interrupt colon cancer progression via ros-mediated ER eestress
- Acetylcholinesterase glycosylation is altered in Alzheimer¿s brain. Role of presenilin 1 and ß-amyloid
- Alfa-sinucleína en LCR mejora el diagnóstico diferencial del deterioro cognitivo leve debido a enfermedad de Alzheimer
- Altered glycosylation of acetylcholinesterase on Alzheimer's brain. Role of presenilin 1
- Antiproliferative effectsof H.sanguineus extracts in breast ans colon cancer cell lines
- Aportación de alfa-sinucleína en LCR al diagnóstico de pacientes con demencia con cuerpos de Lewy prodrómica.
- CSF alpha-synuclein improves early discrimination between Alzheimer¿s disease and Lewy body disease.
- Characterization of cerebrospinal fluid BACE1 as a biomarker for Alzheimer¿s disease
- Combinación de ingredientes a base de polifenoles vegetales con aplicaciones y patologías asociadas a la obesidad
- Contribution of hyperpolarizing ion channels to acute cold hypersensitivity induced by oxaliplatin administration.
- DEREGULATION OF THE WNT AND TGF-ß SIGNALING PATHWAYS UNDERLIES ZIC2-ASSOCIATED HOLOPROSENCEPHALY
- DIFFERENTIAL ACTIVATION OF A NOVEL NON-CANONICAL, ß-CATENIN-DEPENDENT WNT PATHWAY CONTROLS AXON GUIDANCE DECISIONS AT THE MIDLINE
- Development of an in vitro pre-clinical nociceptor model for studying paclitaxel-induced neuropathic pain
- Development of an in vitro pre-clinical nociceptor model for studying paclitaxel-induced neuropathic pain"
- Differential activation of a novel non-canonical, ß-catenin-dependent Wnt pathway controls axon guidance decisions at the midline
- Diseño de péptidos con posible capacidad inhibitoria contra Zika y Dengue
- Effect of a combination of polyphenols derived from Hibiscus sabdariffa L and Lippia citriodora L on stage I hypertensive patients: A randomized controlled trial
- El cerebro humano: El universo hecho consciencia
- Expression of P2X2 purinergic receptor in N2a differentiated cells, as a model to study amyloid beta related pathways
- IFIT5 participates in the antiviral mechanisms of rainbow trout red blood cells
- Identificación y caracterización de nuevos moduladores de TRPM8
- Implementación de nuevas herramientas de innovación docente en el Grado de Biotecnología de la UMH: Evaluación del grado de satisfacción del alumnado.
- Implementación de nuevas herramientas de innovación docente en el Grado de Biotecnología de la UMH: Evaluación del impacto en el rendimiento académico
- Improving a Natural Compound: Design of innovative neurocosmeceuticals for sensitive skin
- In vitro characterization of a TRPV1 soft antagonist.
- In vitro characterization of a TRPV1 soft antagonist.
- In vivo role of TRP channels in an experimental model of chronic migraine.
- Inhibition of glucolipotoxicity-induced metabolic stress by metabolites from Hibiscus sabdariffa on hypertrophied 3T3-L1 adipocytes
- Modulation of TRPV1 channels: from bench to bedside.
- Molecular basis of ion channel modulation: Mapping the conformational states of the outer vestibule of KcsA, a prokaryote potassium channel, using homo-FRET
- Mutación stop en ADAM10 (p.Tyr167*) asociada a Alzheimer familiar: el primer correlato clínico de haploinsuficiencia de alfa-secretasa
- NKEF, an antiviral protein involved in the immune response of rainbow trout red blood cells
- NR2B and phospho-NR2B levels correlate with APOE genotype in Alzheimer human brain cortex
- Polyphenols from Lippia citriodora as potential agonist of the master energy regulator AMPK with synergistic effects
- Quercetin derivatives from Hibiscus sabdariffa to alleviate glucolipotoxicity-induced metabolic stress
- Rainbow trout shape-shifted red blood cells
- Rebound effect in presenilin-1 levels during ¿-secretase inhibition
- Stability of Cerebrospinal Fluid Biomarkers during Processing and Biobank Storage
- Structure-antioxidant activity relationships of isolated compounds from a lemon verbena extract
- Study Chronic Effect of 17- ß -Estradiol Over Trp Channels In Nociceptor Terminals In Microfluidic Chambers.
- Transcriptome and proteome analyses of red blood cells from rainbow trout challenged with viral haemorrhagic septicaemia virus
- Transdifferentiation and microfluidic chambers as tools to approach the in-vivo sketch of human nociceptors
- Transdifferentiation and microfluidic chambers as tools to approach thein-vivosketch of human nociceptors.
- Zic2 regulates Draxin to promote Neural Crest cells delamination
- poster P043
- ¿Ganaremos la guerra contra las superbacterias?
- ¿Podemos predecir la aparición de síntomas psicóticos en los pacientes con enfermedad de Alzheimer en la fase de deterioro cognitivo leve? Estudio preliminar.
- ß -Lactam TRPM8 Antagonists Prevent Chemotherapy-Induced Cold Allodynia.
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event
- 7TH SPANISH-ITALIAN-PORTUGUESE-FRENCH (SIPF) INTERNATIONAL WORKSHOP ON STRUCTURE AND FUNCTION OF ION CHANNELS AND TRANSPORTERS (Congress Organization)
- 12TH EBSA 10TH ICBP-IUPAP CONGRESS (Congress Organization)
- VII REUNIÓN DE LA RED ESPAÑOLA DE CANALES IÓNICOS / RECI VII (Congress Organization)
- XI JORNADA DE SAN ALBERTO MAGNO (Congress Organization)
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external project
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hiring
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invited conference
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operating licence
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person
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person (active)
- CRIADO HERRERO, MANUEL
- CUCHILLO IBAÑEZ, INMACULADA
- DEVESA GINER, ISABEL
- ENCINAR HIDALGO, JOSÉ ANTONIO
- FERNANDEZ ESCAMILLA, ANA MARIA
- FERNÁNDEZ BALLESTER, GREGORIO JOAQUIN
- FERNÁNDEZ CARVAJAL, ASIA
- FERRER MONTIEL, ANTONIO VICENTE
- GARCIA MORALES, MARIA DEL PILAR
- GONZALEZ ROS, JOSE MANUEL
- GUTIERREZ PEREZ, LUIS MIGUEL
- HERRANZ LOPEZ, MARIA DOLORES
- MICOL MOLINA, VICENTE
- MORENILLA PALAO, MARIA CRUZ
- ORTEGA-VILLAIZAN ROMO, MARIA DEL MAR
- PEREZ GARCIA-ESTAÑ, LUIS
- REIG MACIA, JUAN ANTONIO
- SACEDA SANCHEZ, MIGUEL
- SAEZ VALERO, JAVIER
- VILLALAIN BOULLON, JOSÉ
- VILLANUEVA ROIG, JOSE HELIODORO
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research project
- FCT-18-13761
- AICO/2018/090
- APE/2019/017
- BFU2015-63684-P
- BFU2015-66612-P
- DQ0094VF
- GA Nº 639249
- GC0071VF
- GC0072VF
- IDIFEDER/2018/016
- IDIFEDER/2018/017
- IDIFEDER/2018/020
- INNTAL11/19/011
- PGC2018-093505-B-I00
- PI15/00665
- PIEU2018/18
- PROMETEO/2016/006
- RTC-2017-6507-1
- RTI2018-096724-B-C21
- RTI2018-096957-B-C22
- RTI2018-097189-B-C21
- SAF2015-66275-C2-1-R
- UR0023VF
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technological support
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thesis
- DESCUBRIMIENTO Y CARACTERIZACIÓN DE LA ACTIVIDAD ANTIVIRAL INDUCIDA POR LAS MOLÉCULAS TIPO CRP DE PEZ CEBRA (DANIO RERIO)
- ESTUDIO DE LA CAPACIDAD ANTIPROLIFERATIVA EN MODELOS CELULARES DE CÁNCER DE MAMA DE UN EXTRACTO DE HOJA DE OLIVO ENRIQUECIDO EN POLIFENOLES
- EVALUACIÓN DE LOS GENES MGMT, SOCS1 Y SOCS3 COMO MARCADORES MOLECULARES DE QUIMIO Y RADIORRESISTENCIA EN MODELOS CELULARES DE GLIOBLASTOMA HUMANO
- LOS ERITROCITOS NUCLEADOS DE PECES EN LA INMUNIZACIÓN FRENTE A RHABDOVIRUS
- LOS ERITROCITOS NUCLEADOS DE PECES EN LA RESPUESTA INMUNE FRENTE A INFECCIONES VÍRICAS
- POLIFENOLES DE PLANTAS COMESTIBLES COMO REPROGRAMADORES METABÓLICOS EN CONDICIONES DE GLUCOLIPOTOXICIDAD
- THE STRESS-MEDIATED ANTIPROLIFERATIVE EFFECTS OF MARINE INVERTEBRATE EXTRACTS IN HUMAN COLON CANCER CELL MODELS
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thrid party project