Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

GUTIERREZ PEREZ, LUIS MIGUEL

Person (Active)

Positions

Catedrático/a de Universidad, Bioquímica y Biología Molecular 2009 -
PDI INVESTIGADOR, Instituto de Neurociencias 2004 -
MIEMBRO, Grupo de Estudio de los Mecanismos Moleculares de la Neurosecreción 2007 -
Profesor/a Titular Universidad, Bioquímica y Biología Molecular 2007 - 2009
Profesor Titular Universidad, Bioquímica y Biología Molecular 2002 - 2007
Profesor Interino Titular Unv., Bioquímica y Biología Molecular 2000 - 2002
Profesor Titular Universidad, DPTO. NEUROQUIMICA 1998 - 2000
Profesor Interino Titular Unv., DPTO. NEUROQUIMICA 1998 - 2000

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supported publications or other works

selected publications

academic article
- The Role of Nicotinic Receptors on Ca2+ Signaling in Bovine Chromaffin Cells . CURRENT ISSUES IN MOLECULAR BIOLOGY. 808-820. 2024
- Confocal Microscopy Studies of F-Actin Cytoskeleton Distribution and Dynamics Using Fluorescent LifeAct Constructs in Bovine Adrenal Chromaffin Cells. METHODS IN MOLECULAR BIOLOGY. 297-309. 2023
- ALFA3ß4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 9101-9114. 2022
- Vesicle Fusion as a Target Process for the Action of Sphingosine and Its Derived Drugs. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-13. 2022
- Development of the hypersecretory phenotype in the population of adrenal chromaffin cells from prehypertensive SHRs. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1775-1793. 2021
- Multiple sclerosis drug FTY-720 toxicity is mediated by the heterotypic fusion of organelles in neuroendocrine cells. SCIENTIFIC REPORTS. 18471. 2019
- Emerging evidence for the modulatio of exocytosis by signalling lipids. FEBS LETTERS. 1-11. 2018
- Modeling the influence of co-localized intracellular calcium stores on the secretory response of bovine chromaffin cells. COMPUTERS IN BIOLOGY AND MEDICINE. 165-175. 2018
- Multiple Mechanisms Driving F.actin-dependent Transport of Organelles to and from Secretory sites in Bovine Chromaffin Cells. FRONTIERS IN CELLULAR NEUROSCIENCE. 1-12. 2018
- Sphingomimetic multiple sclerosis drug FTY720 activates vesicular synaptobrevin and augments neuroendocrine secretion. SCIENTIFIC REPORTS. 5958. 2017
- The differential organization of F-Actin alters the distribution of organelles in cultured when compared to native chromaffin cells. FRONTIERS IN CELLULAR NEUROSCIENCE. 135. 2017
- The role of F-actin in the transport and secretion of chromaffin granules: an historic perspective.. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 1-6. 2017
- Captivating New Roles of F-Actin Cortex in Exocytosis and Bulk Endocytosis in Neurosecretory Cells. TRENDS IN NEUROSCIENCES. 605-623. 2016
- F-actin cytoskeleton and the fate of organelles in chromaffin cells.. JOURNAL OF NEUROCHEMISTRY. 860-866. 2016
- Sphingomyelin derivatives increase the frquency of microvesicle and granule fusion in chromaffin cells. NEUROSCIENCE. 117-125. 2015
- A THEORETICAL STUDY OF FACTORS INFLUENCING. MATHEMATICAL BIOSCIENCES AND ENGINEERING. 1027-1043. 2014
- Role of Protease-Activated Receptor 2 in Lung Injury Development During Acute Pancreatitis in Rats. PANCREAS. 895-902. 2014
- The distribution of mitochondria and endoplasmic reticulum in. JOURNAL OF CELL SCIENCE. 2014
- Cortical F-actin affects the localization and dynamics of SNAP-25 membrane clusters in chromaffin cells. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 583-592. 2013
- Distribucion mitocondrial en celulas cromafines y su relacion con la secrecion. REVISTA DE NEUROLOGIA. 174-176. 2013
- FTY-720 un analogo de la esfingosina que potencia la liberacion cuantal de catecolaminas. REVISTA DE NEUROLOGIA. 174-176. 2013
- Lipid Metabolites Enhance Secretion Acting on SNARE Microdomains and Altering the Extent and Kinetics of Single Release Events in Bovine Adrenal Chromaffin Cells. PLOS ONE. 75845-75857. 2013
- Neurite extensions in chromaffin cells: study of the influence of the cytoskeletal structure on calcium dynamics and secretion. FRONTIERS IN LIFE SCIENCE. 61-69. 2013
- F-Actin-Myosin II Inhibitors Affect Chromaffin Granule Plasma Membrane Distance and Fusion Kinetics by Retraction of the Cytoskeletal Cortex.. JOURNAL OF MOLECULAR NEUROSCIENCE. 328-338. 2012
- New insights into the role of the cortical cytoskeleton in exocytosis from neuroendocrine cells.. INTERNATIONAL REVIEW OF CELL AND MOLECULAR BIOLOGY. 109-137. 2012
- The f-actin cortex in chromaffin granule dynamics and fusion: a minireview.. JOURNAL OF MOLECULAR NEUROSCIENCE. 1559-1166. 2012
- Calcium entry through slow-inactivating L-type calcium channels preferentially triggers endocytosis rather than exocytosis, in bovine chromaffin cells. . AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY. 86-98. 2011
- Modelling F-actin cortex influence on the secretory properties of neuroendocrine cells. COMMUNICATIVE & INTEGRATIVE BIOLOGY. 1-3. 2011
- P2X7 Receptors Trigger ATP Exocytosis and Modify Secretory Vesicle Dynamics in Neuroblastoma Cells.. JOURNAL OF BIOLOGICAL CHEMISTRY. 11370-11381. 2011
- The F-actin cortical network is a major factor influencing the organization of the secretory machinery in chromaffin cells. JOURNAL OF CELL SCIENCE. 727-734. 2011
- Alpha-synuclein sequesters arachidonic acid to modulate SNARE-mediated exocytosis. EMBO REPORTS. 528-533. 2010
- Association of SNAREs and Calcium Channels with the Borders of Cytoskeletal Cages Organizes the Secretory Machinery in Chromaffin Cells. CELLULAR AND MOLECULAR NEUROBIOLOGY. 1-5. 2010
- Pancreatic and pulmonary mast cells activation during experimental acute pancreatitis.. WORLD JOURNAL OF GASTROENTEROLOGY. 3411-3417. 2010
- The organization of the secretory machinery in chromaffin cells as a major factor in modeling exocytosis. HFSP JOURNAL. 85-92. 2010
- t-SNARE cluster organization and dynamics in chromaffin cells. JOURNAL OF NEUROCHEMISTRY. 1550-1556. 2010
- Simulation of Cytoskeleton Influence on spatial Ca2+ dynamics in neuroendocrine cells. BMC NEUROSCIENCE. 31-32. 2009
- Sphingosine facilitates SNARE complex assembly and activates synaptic vesicle exocytosis. NEURON. 683-694. 2009
- Vesicle Motion and Fusion are Altered in Chromaffin Cells with Increased SNARE Cluster Dynamics. TRAFFIC. 172-185. 2009
- A low nicotine concentration augments vesicle motion and exocytosis triggered by K(+) depolarisation of chromaffin cells. EUROPEAN JOURNAL OF PHARMACOLOGY. 81-86. 2008
- Cytoskeletal control of vesicle transport and exocytosis in chromaffin cells. ACTA PHYSIOLOGICA. 165-172. 2008
- Myosin II contributes to fusion pore expansion during exocytosis. JOURNAL OF BIOLOGICAL CHEMISTRY. 10949-10957. 2008
- Cytoskeletal control of vesicle transport and exocytosis in chromaffin cells.. ACTA PHYSIOLOGICA SCANDINAVICA. 165-169. 2007
- GSK3 activation is essential for the snake PLA2 Neurotoxin induced secretion in chromaffin cells.. EUROPEAN JOURNAL OF NEUROSCIENCE. 2341-2348. 2007
- Vesicle movements are governed by the size and dynamics of F-actin cytoskeletal structures in bovine chromaffin cells.. NEUROSCIENCE. 659-669. 2007
- Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. JOURNAL OF MOLECULAR NEUROSCIENCE. 153-156. 2006
- Tight coupling of the t-SNARE and calcium channel microdomains in adrenomedullary slices and not in cultured chromaffin cells.. CELL CALCIUM. 1-8. 2006
- The Cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- Chromaffin Cell F-actin cytoskeleton real-time dynamics during secretion studied by Transmitted Light and Fluorescence Microscopy.. JOURNAL OF CELL SCIENCE. 2871-2880. 2005
- Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. . JOURNAL OF BIOLOGICAL CHEMISTRY. 27062-27068. 2005
- The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits.. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- New roles of myosin II during the vesicle transport and fusion in chromaffin cells. JOURNAL OF BIOLOGICAL CHEMISTRY. 27450-27457. 2004
- Small peptides patterned after the n-terminus domain of snap25 Inhibit snare complex assembly and regulated exocytosis. JOURNAL OF NEUROCHEMISTRY. 124-135. 2004
- Identification of SNARE complex modulators that inhibit exocytosis from an a-helix-constrained combinatorial library. BIOCHEMICAL JOURNAL. 159-166. 2003
- Ñeco, P., Giner, D., Francés, M.M., Viniegra, S., and Gutiérrez, L.M. (2003). Differential participation of Actin and Tubulin-based Vesicle Transport Systems during Secretion in Bovine Chromaffin Cells.. EUROPEAN JOURNAL OF NEUROSCIENCE. 733-742. 2003
- Ñeco, P., Rosetto, O, Gil, A., Montecucco, C., and Gutiérrez, L.M. (2003). Taipoxin induces F-actin fragmentation and enhances release of catecholamines in bovine chromaffin cells . JOURNAL OF NEUROCHEMISTRY. 329-337. 2003
- Modifications in the C terminus of the synaptosome-associated protein of 25 kDa Snap-25) and in the complementary region of synaptobrevin affect the final steps of exocytosis.. JOURNAL OF BIOLOGICAL CHEMISTRY. 9904-9904. 2002
- Modifications in the C terminus of the synaptosome-associated protein of 25 kDa Snap-25) and in the complementary region of synaptobrevin inhibit secretion through the alteration of membrane fusion kinetics.. JOURNAL OF BIOLOGICAL CHEMISTRY. 9904-9909. 2002
- The role of myosin in vesicle transport during bovine chromaffin cell secretion.. JOURNAL OF BIOCHEMISTRY. 405-413. 2002
- Co-localization of vesicles and P/Q Ca2+-Channels explains the preferential distribution of exocytotic active zones in neurites emitted by bovine chromaffin cells.. EUROPEAN JOURNAL OF CELL BIOLOGY. 358-365. 2001
- The temperature and PMA affect different phases of exocytosis in bovine chromaffin cells.. EUROPEAN JOURNAL NEUROSCIENCE. 1380-1386. 2001
book
- MACRO Y MICROCOSMOS. Una historia del universo y la vida contada entre la ciencia y el arte. JMD EDITORES. 2019
chapter
- ConfocalMicroscopyStudiesofF-ActinCytoskeletonDistributionandDynamicsUsingFluorescentLifeActConstructsinBovineAdrenalChromaffinCells. Chromaffin Cells. Methods and Protocols. 297-309. 2022
- Studies of the Secretory Machinery Dynamics by TotalInternal Reflection Fluorescence Microscopy in BovineAdrenal Chromaffin Cells. SNAREMethods and Protocols. 379-389. 2018
- Understanding the role of mitochondriadistribution in calcium dynamics and secretionin bovine chromaffin cells. Modeling Cellular Systems. 1-11. 2016
congress communication
patent

presentations

invited conference
- The color: the way they exist in nature and its biological and artistical signifiance., Conferencia 2024
- Conferencia en IES dentro de la Semana de la Ciencia: Una visión dinámica de la microscopia., Conferencia 2007
- Conferencia en IES dentro de la Semana de la Ciencia: Una visión dinámica de la microscopia., Conferencia 2007
- Conferencias con ocasión de la Semana de la Ciencia 2006. IES Ifach. Calpe, Conferencia 2006
- Conferencias con ocasión de la Semana de la Ciencia 2006. IES Jorge Juan. Alicante, Conferencia 2006
- Seminario Invitado en Curso de Técnicas Avanzadas en Microscopia de Fluorescencia y Cofocal Espectral, Conferencia 2006
- Seminarios con ocasión de la semana de la ciencia. Conferencia en el IES de Torrellano, Conferencia 2005
- Seminarios con ocasión de la semana de la ciencia. Conferencia en el IES Poeta Paco Molla, Petrel, Conferencia 2005
- Seminarios con ocasión de la semana de la ciencia. Conferencia en el IES Virgen del Remedio, Alicante, Conferencia 2005
- Conferencia invitada MRC-Cambridge, Conferencia 2003
- Conferencia Invitada en el Instituto de Investigaciones citologicas, Conferencia 2003
- Dual stages of BoNTA in the secretory process of chromaffin cells., Conferencia
- Estudio multidisciplinar de la función de proteínas SNARE y del citoesqueleto en la secreción en un modelo neuroendocrino, Conferencia
- La función del citoesqueleto en la secreción en un modelo neuroendocrino., Conferencia
- Leucine 203 plays a critical role in the function of SNAP-25 on exocytotic membrane fusion in chromaffin cells., Conferencia
- Medida de la exocitosis con técnicas de capacitancia y amperometria. Curs de Tecniques de Fisilogia Cel-lular., Conferencia
- Proteínas SNARE y mecanismos de la exocitosis., Conferencia
- SNAP-25 una proteína clave para la fusión exocitótica en un sistema neuroendocrino, Conferencia
- The nature of the secretory pools regulated by the cytoskeletal cortical network disassembly in chromaffin cells., Conferencia
- The role of the cytoskeleton and SNAREs on the secretory process in a neuroendocrine model., Conferencia