CRIADO HERRERO, MANUEL

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Positions

Catedrático/a de Universidad, Bioquímica y Biología Molecular 2007 -
PDI INVESTIGADOR, Instituto de Neurociencias 2004 -
MIEMBRO, Neuroreceptores Asociados a Canales Iónicos 2007 -
Catedrático de Universidad, Bioquímica y Biología Molecular 2000 - 2007
Catedrático de Universidad, DPTO. NEUROQUIMICA 1997 - 2000

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supported publications or other works

selected publications

academic article
- ALFA3ß4 Acetylcholine Nicotinic Receptors Are Components of the Secretory Machinery Clusters in Chromaffin Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 9101-9114. 2022
- Natural Polyhydroxy Flavonoids, Curcuminoids, and Synthetic Curcumin Analogs as ¿7 nAChRs Positive Allosteric Modulators. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 973-989. 2021
- 1¿(2¿,5¿-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1- propanone (RGM079): A Positive Allosteric Modulator of ¿7 Nicotinic Receptors with Analgesic and Neuroprotective Activity. ACS CHEMICAL NEUROSCIENCE. 3900-3909. 2019
- Acetylcholine nicotinic receptor subtypes in chromaffin cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 13-20. 2018
- Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of ¿7 nicotinic receptors with analgesic activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 157-165. 2018
- Functional evidence for the inflammatory reflex in teleosts: A novel ¿7 nicotinic acetylcholine receptor modulates the macrophage response to dsRNA. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 279-291. 2018
- Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of alpha 7 nicotinic receptors with analgesic activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 1-10. 2017
- 1,3-diphenylpropan-1-ones as allosteric modulators of alpha7 nACh receptors with analgesic and antioxidant properties. FUTURE MEDICINAL CHEMISTRY. 731-749. 2016
- N-benzylpiperidine derivatives as alpha7 nicotinic receptor antagonists. ACS CHEMICAL NEUROSCIENCE. 1157-1165. 2016
- Chalcones as positive allosteric modulators of a7 nicotinic acetylcholine receptors: A new target for a privileged structure. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 724-729. 2014
- Effect of Triazine Derivatives on Neuronal Nicotinic Receptors. ACS CHEMICAL NEUROSCIENCE. 683-689. 2014
- Expression and functional properties of ¿7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits. JOURNAL OF NEUROCHEMISTRY. 1-35. 2012
- A small cytoplasmic region adjacent to the fourth transmembrane segment of the alpha7 nicotinic receptor is essential for its biogenesis. FEBS LETTERS. 2477-2480. 2011
- Mutants of beta-strand beta3 and the loop B in the interface between alpha7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations.. JOURNAL OF NEUROCHEMISTRY. 968-978. 2011
- Substitutions of amino acids in the pore domain of homomeric alpha7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties. JOURNAL OF NEUROCHEMISTRY. 40-49. 2011
- Ric-3 promotes alpha7 nicotinic receptor assembly and trafficking through the ER sub-compartment of dendrites. JOURNAL OF NEUROSCIENCE. 10112-10126. 2010
- Role of loop 9 on the function of neuronal nicotinic receptors.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 654-659. 2010
- Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor. JOURNAL OF NEUROCHEMISTRY. 1036-1045. 2010
- The loop between beta-strands beta2 and beta3 and its interaction with the N-terminal alpha-helix is essential for biogenesis of alpha7 nicotinic receptors. JOURNAL OF NEUROCHEMISTRY. 103-111. 2010
- Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 410-416. 2009
- Investigating the role of protein folding and assembly in cell-type dependent expression of alpha7 nicotinic receptors using a green fluorescent protein chimera. BRAIN RESEARCH. 7-16. 2009
- Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors. JOURNAL OF NEUROCHEMISTRY. 1399-1409. 2009
- Single channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor. FEBS LETTERS. 1045-1051. 2009
- Interactions between loop 5 and beta-strand beta6¿ are involved in alpha7 nicotinic acetylcholine receptors channel gating. JOURNAL OF NEUROCHEMISTRY. 719-730. 2008
- Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. JOURNAL OF NEUROCHEMISTRY. 617-627. 2008
- Nicotinic acetylcholine receptors of adrenal chromaffin cells. ACTA PHYSIOLOGICA. 203-212. 2008
- Cytoplasmic regions adjacent to the M3 and M4 transmembrane segments influence expression and function of alpha7 nicotinic acetylcholine receptors. A study with single amino acid mutants. JOURNAL OF NEUROCHEMISTRY. 406-415. 2007
- Non-charged amino acids from three different domains contribute to link agonist binding to channel gating in alpha7 nicotinic acetylcholine receptors.. JOURNAL OF NEUROCHEMISTRY. 725-735. 2007
- Activation and blockade by choline of bovine alpha7 and alpha3beta4 nicotinic receptors expressed in oocytes. EUROPEAN JOURNAL OF PHARMACOLOGY. 53-60. 2006
- Activation and blockade of choline of bovine alpha7 and alpha3beta4 nicotinic receptors expressed in oocytes. EUROPEAN JOURNAL OF PHARMACOLOGY. 53-60. 2006
- Improved gating of a chimeric alpha7-5HT3A receptor upon mutations at the M2-M3 extracellular loop. FEBS LETTERS. 256-260. 2006
- Intragranular pH rapidly modulates exocytosis in adrenal chromaffin cells. JOURNAL OF NEUROCHEMISTRY. 324-334. 2006
- Role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. JOURNAL OF MOLECULAR NEUROSCIENCE. 153-156. 2006
- The Cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- Charged Amino Acids of the N-terminal Domain Are Involved in Coupling Binding and Gating in alpha7 Nicotinic Receptors . JOURNAL OF BIOLOGICAL CHEMISTRY. 6642-6647. 2005
- Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. . JOURNAL OF BIOLOGICAL CHEMISTRY. 27062-27068. 2005
- Mutations of a conserved lysine residue in the N-terminal domain of alpha7 nicotinic receptors affect gating and binding of nicotinic agonists. MOLECULAR PHARMACOLOGY. 1669-1677. 2005
- Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite. NEUROSCIENCE LETTERS. 144-149. 2005
- Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite. . NEUROSCIENCE LETTERS. 144-149. 2005
- The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits.. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- A choline evoked [Ca2+]c signal causes catecholamine release and hyperpolarization of chromaffin cells. . FASEB J. 469-470. 2004
- El receptor nicotínico de acetilcolina. MENTE Y CEREBRO. 10-16. 2004
- Glucocorticoid activation of the neuronal nicotinic acetylcholine receptor alpha7 subunit gene. Involvement of transcription factor Egr-1. FEBS LETTERS. 247-250. 2004
- Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. JOURNAL OF BIOLOGICAL CHEMISTRY. 34411-34417. 2003
- Immunohistochemical localization of the voltage-gated potassium channel subunit Kv1.4 in the central nervous system of the adult rat. JOURNAL OF CHEMICAL NEUROANATOMY. 209-224. 2003
- Transcriptional regulation by activation and repression elements located at the 5'-non coding region of the human alpha9 nicotinic receptor subunit gene. JOURNAL OF BIOLOGICAL CHEMISTRY. 37249-37255. 2003
- A single neuronal nicotinic receptor alpha3alpha7beta4 is present in the bovine chromaffin cell.. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 165-167. 2002
- Effects of benzothiazepines on human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.. BRITISH JOURNAL OF PHARMACOLOGY. 183-192. 2002
- Effects of gingenoside Rg2 on human neuronal nicotinic acetylcholine receptors.. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1052-1059. 2002
- Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes.. EUROPEAN JOURNAL OF PHARMACOLOGY. 37-45. 2002
- Modifications in the C terminus of the synaptosome-associated protein of 25 kDa Snap-25) and in the complementary region of synaptobrevin affect the final steps of exocytosis.. JOURNAL OF BIOLOGICAL CHEMISTRY. 9904-9904. 2002
- Modifications in the C terminus of the synaptosome-associated protein of 25 kDa Snap-25) and in the complementary region of synaptobrevin inhibit secretion through the alteration of membrane fusion kinetics.. JOURNAL OF BIOLOGICAL CHEMISTRY. 9904-9909. 2002
- Role of the large cytoplasmic loop of the alpha7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function.. BIOCHEMISTRY. 7931-7938. 2002
- Transcription factors NF-Y and Sp-1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta4 subunit genes.. JOURNAL OF BIOLOGICAL CHEMISTRY. 8866-8876. 2002
- Activity of the nicotinic acetylcholine receptor alpha5 and alpha7 subunit promoters in muscle cells.. DNA AND CELL BIOLOGY. 657-666. 2001
- Multiple roles of the conserved residue arginine 209 in neuronal nicotinic receptors.. BIOCHEMISTRY. 8300-8306. 2001
- Papel del residuo conservado arginina 209 en los receptores nicotínicos neuronales.. NEUROLOGY. 2001
- Multiple functional Sp1 domains in the minimal promoter region of the neuronal nicotinic alpha5 subunit gene. JOURNAL OF BIOLOGICAL CHEMISTRY. 4693-4701. 1999
- alpha-Bungarotoxin-sensitive nicotinic receptors on bovine chromaffin cells: molecular cloning, functional expression, and alternative splicing of the a7 subunit. EUROPEAN JOURNAL OF NEUROSCIENCE. 647-665. 1995
chapter
- Choline as a tool to evaluate nicotinic receptor function in chromaffin cells. . CELL BIOLOGY OF THE CHROMAFFIN CELL. 255-259. 2004
- Choline as a tool to evaluate nicotinicreceptor function in chromaffin cells.. CELL BIOLOGY OF THE CHROMAFFIN CELL. 255-259. 2004
- Does an homomeric alpha7 nicotinic receptor exist in bovine chromaffin cells? . CELL BIOLOGY OF THE CHROMAFFIN CELL. 251-254. 2004
- Does an homomeric alpha7 nicotinicreceptor exist in bovine chromaffincells?. CELL BIOLOGY OF THE CHROMAFFIN CELL. 251-254. 2004
- Second messengers control the kinetics of exocytosis by modifying the intravesicular pH. CELL BIOLOGY OF THE CHROMAFFIN CELL. 23-28. 2004
- The secretory responses to choline and acetylcholine show different patterns and calcium dependence in chromaffin cells. CELL BIOLOGY OF THE CHROMAFFIN CELL. 243-249. 2004
congress communication

presentations

invited conference
- Gating of alpha7 nicotinic receptors from chromaffin cells: the role of domains near the agonist binding site., Conferencia 2007
- XII International Symposium on Cholinergic Mechanisms, Conferencia 2005
- VIII Curso de Doctorado sobre la Señal Celular del Calcio, Conferencia 2005
- XV Curso avanzado para postgraduados sobre Receptores para Neurotransmisores, Conferencia 2005
- The Ric-3 protein: an effector of nicotinic acetylcholine receptor expression, Conferencia 2003
- Biología y estructura molecular de los receptores asociados a canales iónicos, Conferencia 2003
- Biología y estructura molecular de los receptores asociados a canales iónicos, Conferencia
- Biología y estructura molecular de los receptores asociados a canales iónicos., Conferencia
- Biología y estructura molecular de los receptores asociados a canales iónicos., Conferencia
- Estructura molecular y función de los receptores nicotínicos, Conferencia
- Genoma y cerebro., Conferencia

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CRIADO HERRERO, MANUEL

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