FERNÁNDEZ BALLESTER, GREGORIO JOAQUIN

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Positions

Catedrático/a de Universidad, Bioquímica y Biología Molecular 2017 -
PDI INVESTIGADOR, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2018 -
MIEMBRO, Moléculas bioactivas 2012 -
PDI INVESTIGADOR, Instituto de Biología Molecular y Celular 2004 - 2018
Profesor Titular Universidad, Bioquímica y Biología Molecular 2009 - 2017
Profesor/a Titular Universidad, Bioquímica y Biología Molecular 2009 - 2017
Profesor/a Contratado/a Doctor/a, Bioquímica y Biología Molecular 2005 - 2009
Profesor/a Colaborador/a, Bioquímica y Biología Molecular 2002 - 2005
Ayudante de Universidad, Bioquímica y Biología Molecular 2000 - 2002
Ayudante de Universidad, DPTO. NEUROQUIMICA 1997 - 2000

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supported publications or other works

selected publications

academic article
- Design and Validation of Novel Potential Antiperspirant Peptides Blocking M3-G¿q Sweat Signaling Cascade. INTERNATIONAL JOURNAL OF PEPTIDE RESEARCH AND THERAPEUTICS. 1-12. 2024
- Identification of novel inhibitors of plant GH3 IAA-amido synthetases through molecular docking studies. PHYSIOLOGIA PLANTARUM. 1-13. 2024
- The multicomponent Passerini reaction as a means of accessing diversity in structure, activity and properties: soft and hard vanilloid/cannabinoid modulators. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 11684. 2024
- Design and validation of neuronal exocytosis blocking peptides as potential novel antiperspirants.. EXPERIMENTAL DERMATOLOGY. 999-1006. 2023
- beta-Lactam TRPM8 Antagonists Derived from Phe-Phenylalaninol Conjugates: Structure-Activity Relationships and Antiallodynic Activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 14849-14871. 2023
- Conformational buffering underlies functional selection in intrinsically disordered protein regions. NATURE STRUCTURAL & MOLECULAR BIOLOGY. 781-790. 2022
- TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy. FRONTIERS IN MOLECULAR NEUROSCIENCE. 930964. 2022
- ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention.. PHARMACOLOGY & THERAPEUTICS. 108297. 2022
- ß-Lactam TRPM8 antagonist RGM8-51 displays analgesic activity in different animal models. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2692-2716. 2022
- A capsaicinoid¿based soft drug, AG1529, for attenuating TRPV1¿mediated histaminergic and inflammatory sensory neuron excitability. SCIENTIFIC REPORTS. 246-256. 2021
- Peimine, an anti-inflammatory compound from Chinese herbal extracts, modulates muscle-type nicotinic receptors.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 11287-11313. 2021
- Phenylalanine-derived beta-Lactam TRPM8 modulators. Configuration effect on the antagonist activity. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2370-2392. 2021
- Highly functionalized ß-lactams and 2-ketopiperazines as TRPM8 antagonists with antitumor and antiallodynic activity.. SCIENTIFIC REPORTS. 14154-14165. 2020
- Investigational drugs in early phase clinical trials targeting thermotransient receptor potential (thermoTRP) channels. EXPERT OPINION ON INVESTIGATIONAL DRUGS. 1-14. 2020
- Moduladores del termorreceptor TRPV1 desactivables metabólicamente en la farmacología. ACTUALIDAD EN FARMACOLOGIA Y TERAPEUTICA. 162-172. 2020
- Targeting thermoTRP ion channels: in silico preclinical approaches and opportunities. EXPERT OPINION ON THERAPEUTIC TARGETS. 1-19. 2020
- Mechanisms of blockade of the muscle-type nicotinic receptor by benzocaine, a permanently uncharged local anesthetic. NEUROSCIENCE. 1-2. 2019
- Structure-based design of novel biphenyl amide antagonists of human Transient Receptor Potential Cation Channel Subfamily M Member 8 channels (TRPM8) with potential implications in the treatment of sensory neuropathies.. ACS CHEMICAL NEUROSCIENCE. 2100-2110. 2019
- The calmodulin-binding tetraleucine motif of KCNE4 is responsible for association with Kv1.3. FASEB J. 8263-8279. 2019
- Mechanisms underlying the strong inhibition of muscle-type nicotinic receptors by tetracaine. FRONTIERS IN MOLECULAR NEUROSCIENCE. 1-21. 2018
- Synthesis, high-throughput screening and pharmacological characterization of ß-lactam derivatives as TRPM8 antagonists. SCIENTIFIC REPORTS. 10766-10779. 2017
- Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.. FRONTIERS IN MOLECULAR NEUROSCIENCE. 127-141. 2016
- _Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.. FRONTIERS IN MOLECULAR NEUROSCIENCE. 12-23. 2016
- Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in KcsA. JOURNAL OF BIOLOGICAL CHEMISTRY. 1-15. 2015
- Hyaluronan modulates TRPV1 channel opening, reducing peripheral nociceptor activity and pain. NATURE COMMUNICATIONS. 8095-8106. 2015
- In silico approach for the discovery of new PPAR-gamma modulators among plant-derived polyphenols.. DRUG DESIGN DEVELOPMENT AND THERAPY. 5877-5895. 2015
- Molecular binding mechanism of TtgR repressor to antibiotics and antimicrobials. PLOS ONE. 1-15. 2015
- TRP channels interaction with lipids and its implications in disease.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1818-1827. 2015
- The Integrity of the TRP Domain Is Pivotal for Correct TRPV1 Channel Gating. BIOPHYSICAL JOURNAL. 529-541. 2015
- Lipid modulation of ion channels through specific binding sites.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1560-1567. 2014
- Mutation of I696 and W697 in the Trp box of vanilloid receptor subtype I modulates allosteric channel activation. JOURNAL OF GENERAL PHYSIOLOGY. 361-375. 2014
- Novel BRAFI599ins mutation identified in a follicular variant of papillary thyroid carcinoma: a molecular modeling approach. ENDOCRINE PRACTICE. 75-79. 2014
- The region adjacent to the C-end of the inner gate in Transient Receptor Potential Melastatin 8 (TRPM8) channels plays a central role in allosteric channel activation. JOURNAL OF BIOLOGICAL CHEMISTRY. 28579-28594. 2014
- A non-cannonical di-acidic signal at the C-terminus of Kv1.3 determines anterograde trafficking and surface expression. JOURNAL OF CELL SCIENCE. 5681-5691. 2013
- Targeting protein-protein interactions to rescue ¿f508-cftr: a novel corrector approach to treat cystic fibrosis.. EMBO MOLECULAR MEDICINE. 1462-1464. 2013
- Advances in modulating thermosensory TRP channels. EXPERT OPINION ON THERAPEUTIC TARGETS. 999-1017. 2012
- In silico-based direct evolution of peptides and peptidomimetics in drug discovery. CURRENT TOPICS IN PHARMACOLOGY. 35-55. 2012
- Mutation of Ser-50 and Cys-66 in Snapin Modulates Protein Structure and Stability. BIOCHEMISTRY. 3470-3484. 2012
- New strategies to develop novel pain therapies: Addressing thermoreceptors from different points of view.. PHARMACEUTICALS. 16-48. 2012
- Estrogen destabilizes microtubules through an ion-conductivity-independent TRPV1 pathway. JOURNAL OF NEUROCHEMISTRY. 5397-5404. 2011
- Ionic channels as targets for drug design: a review on computational methods. PHARMACEUTICS. 1-11. 2011
- Membrane-tethered peptides patterned after the TRP domain (TRPducins) potently and selectively inhibit TRPV1 channel activity. . FASEB J. 1628-1640. 2011
- The role of the transient receptor potential vanilloid 1 (TRPV1) in inflammation and sepsis.. JOURNAL OF INFLAMMATION RESEARCH. 67-81. 2011
- Occupancy of non-annular lipid Binding sites on kcsA greatly increases the stability of the tetrameric protein. . BIOCHEMISTRY. 5397-5404. 2010
- ADAN: a database for prediction of protein-protein interaction of modular domains. BIOINFORMATICS. 2418-2424. 2009
- Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.. MOLECULAR PAIN. 62-75. 2009
- Interaction with the multiple PDZ domain protein MUPP1 targets the human somatostatin receptor 3 to epithelial tight junctions.. FEBS LETTERS. 49-54. 2009
- Structure-based prediction of the S. cerevisiae SH3-ligand interactions. JOURNAL OF MOLECULAR BIOLOGY. 902-916. 2009
- Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J. 3298-3306. 2008
- Impaired BRAF activity mutant, Gly474Arg, in anaplastic thyroid carcinomas. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 2008
- Molecular modelling of the full length human TRPV1 channel in a closed and desensitized states. JOURNAL OF MEMBRANE BIOLOGY. 161-172. 2008
- N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.. JOURNAL OF BIOLOGICAL CHEMISTRY. 18076-18085. 2008
- A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating. JOURNAL OF NEUROSCIENCE. 11641-11650. 2007
- Control of Drosophila gastrulation by apical localisation of adherens junctions and RhoGEF2. SCIENCE. 384-386. 2007
- Dynamics of tryptophan in the histidine-containing phosphocarrier protein of Streptomyces coelicolor: evidence of multistate equilibrium unfolding. BIOCHEMISTRY. 7252-7260. 2007
- High frequency of germline Succinate Dehydrogenase mutations in sporadic cervical paragangliomas in Northern Spain: Mitochondrial succinate dehydrogenase structure-function relationships and clinical-pathological correlations. JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM. 4853-4864. 2007
- Biophysical characterization of the Enzyme I of the Streptomyces coelicolor phosphoenolpyruvate: sugar phosphor.-transferase system. BIOPHYSICAL JOURNAL. 4592-4604. 2006
- Computer modelling in combination with in vitro studies reveals similar binding affinities of Drosophila crumbs for the PDZ domains of stardust and DmPar-6. EUROPEAN JOURNAL OF CELL BIOLOGY. 753-767. 2006
- New approaches to high-throughput structure characterization of SH3 complexes: The example of Myosin-3 and Myosin-5 SH3 domains from S. cerevisiae. PROTEIN SCIENCE. 795-807. 2006
- Molecular compatibility of the channel gate and the N-terminus of S5 segment for voltage-gated channel activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 18253-18264. 2005
- Identification of a tetramerization domain in the C-terminus of the the vanilloid receptor. JOURNAL OF NEUROSCIENCE. 5307-5314. 2004
- Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA. BIOCHEMISTRY. 14924-14931. 2004
- Modulation of botulinum neurotoxin A catalytic domain by tyrosine phosphorylation. FEBS LETTERS. 121-127. 2004
- Molecular architecture of the vanilloid receptor: insights for drug design. EUROPEAN JOURNAL OF BIOCHEMISTRY. 1820-1826. 2004
- Small peptides patterned after the n-terminus domain of snap25 Inhibit snare complex assembly and regulated exocytosis. JOURNAL OF NEUROCHEMISTRY. 124-135. 2004
- Stabilization of TRAIL, an all beta-sheet multimeric protein using computational redesign. PROTEIN ENGINEERING. 673-680. 2004
- The Triptophan Switch: Changing Ligand Binding Specificity from Type I to Type II in SH3 Domains. JOURNAL OF MOLECULAR BIOLOGY. 619-629. 2004
- Identification of SNARE complex modulators that inhibit exocytosis from an a-helix-constrained combinatorial library. BIOCHEMICAL JOURNAL. 159-166. 2003
- Ligand screening by exoproteolysis and mass spectroscopy in combination with computer modelling.. JOURNAL OF MOLECULAR BIOLOGY. 1039-1048. 2003
- Resistance of citrus rootstocks to saline stress based on their ability to regulate ion absorption to the shoot. TREE PHYSIOLOGY. 265-271. 2003
- The histidine-phosphocarrier protein of Streptomyces coelicolor folds by a partially folded species at low pH. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2254-2267. 2003
- Computer-aided design of a PDZ domain to recognise new target sequences.. NATURE STRUCTURAL BIOLOGY. 621-627. 2002
- Targeting and delivery of small peptides patterned after the N-terminus domain of SNAP-25 that inhibit regulated exocytosis.. SOCIETY FOR NEUROSCIENCE ABSTRACTS. 2001
- Thermal stabilization of the catalytic domain of Botulinum Neurotoxin E by phosphosylation of a single tyrosine residue.. BIOCHEMISTRY. 2234-2242. 2001
chapter
- In Silico Approaches for TRP Channel Modulation. Methods in molecular biology. 187-206. 2019
- TRP channels in sensory transduction. Pharmacology of TRP Channels. En: TRP channels in sensory transduction.. 41-71. 2015
- Prediction of Protein Interaction Based on Structure. Protein Design: Methods and Applications. 207-234. 2006
congress communication
patent

presentations

invited conference
- Structural insights into the dynamics of the TRPA1 activation mechanism, Conferencia 2012
- Structural Bioinformatics and Modelling of Membrane Proteins, Conferencia 2008
- Structural bioinformatics and modelling of membrane proteins, Conferencia 2008
- La química combinatoria en el desarrollo de nuevos fármacos, Conferencia 2008
- Computational methods to predict protein-protein interaction based on structure, Conferencia 2007
- Improving ADAN database: searching putative ligands and patterns in the genomes, Conferencia 2007
- Modelling and prediction of protein-protein interactions in ADAN database, Conferencia 2007
- Prediction of protein-protein interactions in ADAN database, Conferencia 2006
- Predicción de interacciones proteína-proteína, Conferencia 2005
- Design of proteases for neurodegenerative diseases, Conferencia 2004
- Design of a scFv binding to DR-5 Receptors, Conferencia 2004
- Prediction of SH3-ligand interaction based on structure, Conferencia 2004
- SH3 domain selection for prediction of SH3-ligand interaction, Conferencia 2003
- Scaffold design to emulate Trail trimers, Conferencia 2003
- Prediction of SH3-ligand interaction based on structure, Conferencia 2003
- TRAIL Protein Design, Conferencia 2003
- SH3 ligand prediction based on structure: Nebulin and boi2 and r167 domains, Conferencia 2002
- Stabilization of the trimeric protein Trail, Conferencia 2002
- Diseño de proteínas computacional., Conferencia 2002
- Prediction of the ligands of SH3 domains from S. cerevisiae and S. pombe., Conferencia 2002
- TPR domain as a model for the study of protein-protein interactions, Conferencia 2001

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FERNÁNDEZ BALLESTER, GREGORIO JOAQUIN

Positions

Publications

supported publications or other works

selected publications

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