Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

ENCINAR HIDALGO, JOSÉ ANTONIO

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Positions

Profesor/a Titular Universidad, Bioquímica y Biología Molecular 2009 -
PDI INVESTIGADOR, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2018 -
MIEMBRO, Compuestos bioactivos naturales 2019 -
SECRETARIO/A DE INSTITUTO, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2018 - 2019
MIEMBRO, Relaciones Estructura-función en Proteínas de Membrana 2012 - 2019
PDI INVESTIGADOR, Instituto de Biología Molecular y Celular 2004 - 2018
SECRETARIO/A DE INSTITUTO, Instituto de Biología Molecular y Celular 2016 - 2018
Profesor/a Contratado/a Doctor/a, Bioquímica y Biología Molecular 2005 - 2009
Profesor/a Colaborador/a, Bioquímica y Biología Molecular 2002 - 2005
Ayudante de Universidad, Bioquímica y Biología Molecular 2000 - 2002
Ayudante de Universidad, DPTO. NEUROQUIMICA 1997 - 2000

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selected publications

academic article
- PTPRK regulates glycolysis and de novo lipogenesis to promote hepatocyte metabolic reprogramming in obesity.. NATURE COMMUNICATIONS. 1-22. 2024
- Silibinin is a suppressor of the metastasis-promoting transcription factor ID3. PHYTOMEDICINE. 1-16. 2024
- Specific targeting of the NRF2/ß-TrCP axis promotes beneficial effects in NASH. REDOX BIOLOGY. 1-12. 2024
- The Fatty Acid Synthase (FASN) signalome: A molecular guide for precision oncology.. MOLECULAR ONCOLOGY. 1-76. 2023
- An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter beta-TrCP delivers anti-inflammatory responses in mouse liver. REDOX BIOLOGY. 1-17. 2022
- G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER¿ and ERß in pancreatic beta cells. ENVIRONMENT INTERNATIONAL. 107250-107262. 2022
- Silibinin Overcomes EMT-Driven Lung Cancer Resistance to New-Generation ALK Inhibitors. CANCERS. 1-23. 2022
- Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-19. 2022
- The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases. MARINE DRUGS. 1-14. 2022
- The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and beta-TrCP-NRF2 interactions in cancer chemoresistance. FREE RADICAL BIOLOGY AND MEDICINE. 246-260. 2022
- ERK5 Signaling Pathway Is A Novel Target Of Sorafenib: Implication In EGF Biology.. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 1-13. 2021
- Metformin Is a Pyridoxal-5¿-phosphate (PLP)-Competitive Inhibitor of SHMT2. CANCERS. 4009-4036. 2021
- Peimine, an anti-inflammatory compound from Chinese herbal extracts, modulates muscle-type nicotinic receptors.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 11287-11313. 2021
- Bisphenol-S and Bisphenol-F alter mouse pancreatic ß-cell ion channel expression and activity and insulin release through an estrogen receptor ERß mediated pathway. CHEMOSPHERE. 1-14. 2020
- Differential Effects of IGF-1R Small Molecule Tyrosine Kinase Inhibitors BMS-754807 and OSI-906 on Human Cancer Cell Lines. CANCERS. 1-18. 2020
- Location, Orientation and Aggregation of Bardoxolone-ME, CDDO-ME, in a Complex Phospholipid Bilayer Membrane. JOURNAL OF MEMBRANE BIOLOGY. 115-128. 2020
- Potential Drugs Targeting Early Innate Immune Evasion of SARS-Coronavirus 2 via 2¿-O-Methylation of Viral RNA. VIRUSES-BASEL. 1-25. 2020
- Quercetin metabolites from Hibiscus sabdariffa contribute to alleviate glucolipotoxicity-induced metabolic stress in vitro. FOOD AND CHEMICAL TOXICOLOGY. 1-14. 2020
- Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity. AGING-US. 8-34. 2020
- Silibinin and SARS-CoV-2: Dual Targeting of Host Cytokine Storm and Virus Replication Machinery for Clinical Management of COVID-19 Patients. JOURNAL OF CLINICAL MEDICINE. 1-22. 2020
- The Interaction of Temozolomide with Blood Components Suggests the Potential Use of Human Serum Albumin as a Biomimetic Carrier for the Drug. BIOMOLECULES. 1-22. 2020
- he LSD1 inhibitor iadademstat (ORY-1001) targets SOX2-driven breast cancer stem cells: a potential epigenetic therapy in luminal-B and HER2-positive breast cancer subtypes.. AGING-US. 4794-4814. 2020
- Antiviral Activity of a Turbot (Scophthalmus maximus) NK-Lysin Peptide by Inhibition of Low-pH Virus-Induced Membrane Fusion. MARINE DRUGS. 2019
- Extra Virgin Olive Oil Contains a Phenolic Inhibitor of the Histone Demethylase LSD1/KDM1A.. NUTRIENTS. 1-16. 2019
- IFIT5 Participates in the Antiviral Mechanisms of Rainbow Trout Red Blood Cells.. FRONTIERS IN IMMUNOLOGY. 1-15. 2019
- Resveratrol targets PD-L1 glycosylation and dimerization to enhance antitumor T-cell immunity.. AGING-US. 1-25. 2019
- Revisiting silibinin as a novobiocin-like Hsp90¿C-terminal inhibitor: Computational modeling and experimental validation.. FOOD AND CHEMICAL TOXICOLOGY. 110645-110657. 2019
- The Potential Synergistic Modulation of AMPK by Lippia citriodora Compounds as a Target in Metabolic Disorders. NUTRIENTS. 2961-2978. 2019
- The extra virgin olive oil phenolic oleacein is a dual substrate-inhibitor of catechol-O-methyltransferase.. FOOD AND CHEMICAL TOXICOLOGY. 35-45. 2019
- Antimicrobial Capacity of Plant Polyphenols against Gram-positive Bacteria: A Comprehensive Review. CURRENT MEDICINAL CHEMISTRY. 1-2. 2018
- Chromatin immunoprecipitation and high throughput sequencing of SVCV-infected zebrafish reveals novel epigenetic histone methylation patterns involved in antiviral immune response. FISH & SHELLFISH IMMUNOLOGY. 514-521. 2018
- Discovery of nonnucleoside inhibitors of polymerase from infectious pancreatic necrosis virus (IPNV). DRUG DESIGN DEVELOPMENT AND THERAPY. 2337-2359. 2018
- New Mammalian Target of Rapamycin (mTOR) Modulators Derived from Natural Product Databases and Marine Extracts by Using Molecular Docking Techniques. MARINE DRUGS. 385-395. 2018
- Plant-derived polyphenols in human health: biological activity, metabolites and putative molecular targets.. CURRENT DRUG METABOLISM. 1-22. 2018
- Turbot (Scophthalmus maximus) Nk-lysin induces protection against the pathogenic parasite Philasterides dicentrarchi via membrane disruption. FISH & SHELLFISH IMMUNOLOGY. 190-199. 2018
- AMPK modulatory activity of olive-tree leaves phenolic compounds: Bioassay-guided isolation on adipocyte model and in silico approach. PLOS ONE. 1-22. 2017
- An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs. MOLECULES. 1037-1050. 2017
- Multi-Targeted Molecular Effects of Hibiscus sabdariffa Polyphenols: An Opportunity for a Global Approach to Obesity. NUTRIENTS. 1-27. 2017
- Neutralization of viral infectivity by zebrafish c-reactive protein isoforms. MOLECULAR IMMUNOLOGY. 145-155. 2017
- Nutraceuticals molecular targets (II) A novel way of approaching health by using nutraceuticals: Combined -omics and virtual screening. AGRO FOOD INDUSTRY HI-TECH. 12-13. 2017
- Nutraceuticals molecular targets (III) Targeting protein receptors with polyphenols as new anti-obesity therapies. AGRO FOOD INDUSTRY HI-TECH. 1-2. 2017
- Looking for inhibitors of the dengue virus NS5 RNA-dependent RNA-polymerase using a molecular docking approach. DRUG DESIGN DEVELOPMENT AND THERAPY. 3163-3181. 2016
- Structure and functionalities of the human c-reactive protein compared to the zebrafish multigene family of c-reactive-like proteins. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY. 33-40. 2016
- Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in KcsA. JOURNAL OF BIOLOGICAL CHEMISTRY. 1-15. 2015
- In silico approach for the discovery of new PPAR-gamma modulators among plant-derived polyphenols.. DRUG DESIGN DEVELOPMENT AND THERAPY. 5877-5895. 2015
- Hepatitis C virus polymerase¿polymerase contact interface: Significance for virus replication and antiviral design. ANTIVIRAL RESEARCH. 14-24. 2014
- Lipid modulation of ion channels through specific binding sites.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1560-1567. 2014
- Nucleotide binding triggers a conformational change of the CBS module of the magnesium transporter CNNM2 from a twisted towards a flat structure. BIOCHEMICAL JOURNAL. 23-34. 2014
- Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 193-200. 2013
- Partitioning of Liquid-ordered / Liquid-disordered Membrane Microdomains Induced by the Fluidifying Effect of 2-Hydroxylated Fatty Acid Derivatives.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2553-2563. 2013
- pH-dependent solution structure and activity of the host-defense peptide myticin C (Myt C) from the mussel Mytilus galloprovincialis.. MARINE DRUGS. 2328-2346. 2013
- Contribution of ion binding affinity to ion selectivity and permeation in KcsA, a model potassium channel.. BIOCHEMISTRY. 3891-3900. 2012
- Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 0-11. 2012
- Mutation of Ser-50 and Cys-66 in Snapin Modulates Protein Structure and Stability. BIOCHEMISTRY. 3470-3484. 2012
- De novo polymerase activity and oligomerization of Hepatitis C Virus RNA-dependent RNApolymerases from genotypes 1 to 5.. PLOS ONE. 1-12. 2011
- Nucleotide-induced conformational transitions in the CBS domain protein MJ0729 of Methanocaldococcus jannaschii. PROTEIN ENGINEERING DESIGN & SELECTION. 161-169. 2011
- Binding of 5¿-methylthioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-close conformational change in its CBS motif pair.. JOURNAL OF MOLECULAR BIOLOGY. 800-820. 2010
- Ion binding to KcsA: implications in ion selectivity and channel gating. BIOCHEMISTRY. 9480-9487. 2010
- Nucleotide-induced conformational transitions in the CBS domain protein MJ0729 of Methanocaldococcus jannaschii.. PROTEIN ENGINEERING DESIGN & SELECTION. 1-9. 2010
- Occupancy of non-annular lipid Binding sites on kcsA greatly increases the stability of the tetrameric protein. . BIOCHEMISTRY. 5397-5404. 2010
- ADAN: a database for prediction of protein-protein interaction of modular domains. BIOINFORMATICS. 2418-2424. 2009
- Interaction of transmembrane-spanning segments of the ¿2-adrenergic receptor with model membranes. MOLECULAR MEMBRANE BIOLOGY. 265-278. 2009
- The CBS-domain protein MJ0729 of Methanococcus jannaschii is a thermostable protein with pH-dependent homooligomeric species.. BIOCHEMISTRY. 2760-2776. 2009
- Metal-triggered changes in the stability and secondary structure of a tetrameric dihydropyrimidinase: A biophysical characterization. BIOPHYSICAL CHEMISTRY. 42-52. 2008
- N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.. JOURNAL OF BIOLOGICAL CHEMISTRY. 18076-18085. 2008
- Protein-promoted membrane domains.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1583-1590. 2008
- Interaction of the c-terminal region of the gamma-protein with model membranes.. BIOPHYSICAL JOURNAL. 2530-2541. 2007
- Clustering and Coupled Gating Modulate the Activity in KcsA, a Potassium Channel Model. JOURNAL OF BIOLOGICAL CHEMISTRY. 18837-18848. 2006
- Effects of conducting and blocking ions on the structure and stability of the potassium channel kcsa.. JOURNAL OF BIOLOGICAL CHEMISTRY. 29905-29915. 2006
- Nicotinic acetylcholine receptor properties are modulated by the surrounding lipids: an ¿in vivo¿ study. JOURNAL OF MOLECULAR NEUROSCIENCE. 5-6. 2006
- Structural and functional changes induced in the nicotinic acetylcholine receptor by membrane phospholipids. JOURNAL OF MOLECULAR NEUROSCIENCE. 121-124. 2006
- The XII International Symposium on Cholinergic Mechanisms.. JOURNAL OF MOLECULAR NEUROSCIENCE. 1-2. 2006
- The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA. FEBS LETTERS. 5199-5204. 2005
- Unfolding and Refolding in Vitro of a Tetrameric, alpha-Helical Membrane Protein: The Prokaryotic Potassium Channel KcsA. BIOCHEMISTRY. 14344-14352. 2005
- Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA. BIOCHEMISTRY. 14924-14931. 2004
- Intrinsic Tyrosine fluorescence as a tool to study the interaction of the Shaker B ball peptide with anionic membranes. BIOCHEMISTRY. 7124-7132. 2003
- Probing The Channel-Bound Shaker B Inactivating Peptide By Stereoisomeric Substitution At A Strategic Tyrosine Residue.. BIOCHEMISTRY. 8879-8884. 2003
- Salmonid viral haemorrhagic septicaemia virus: fusion-related enhancement of virus infectivity by peptides derived from viral glycoprotein G or a combinatorial library.. JOURNAL OF GENERAL VIROLOGY. 2671-2681. 2002
- Segregation of Phosphatidic Acid-Rich Domains in Reconstituted Acetylcholine Receptor Membranes. BIOCHEMISTRY. 12253-12262. 2002
- Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. BIOCHEMISTRY. 12253-12262. 2002
- Tyrosine Phosphorylation of the Inactivating Peptide of the Shaker B Potassium Channel: A Structural-Functional Correlate.. BIOCHEMISTRY. 12263-12269. 2002
- A protein G fragment from the salmonid VHS rhabdovirus induces cell-to-cell fusion and membrane phosphatidylserine translocation at low pH?. JOURNAL OF BIOLOGICAL CHEMISTRY. 46268-46275. 2001
- Human p8 is a HMG-I/Y protein with DNA binding activity enhanced by phosphorilation.. JOURNAL OF BIOLOGICAL CHEMISTRY. 2742-2751. 2001
chapter
- Structural and functional modulation of ion channels by specific lipids: from model systems to cell membranes. . Protein-lipid interactions. 203-233. 2006
- Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. Cholinergic Mechanisms: Function and Dysfunction. 665-669. 2004
- The segregation of a lipid domain underlies structural and functional modulation of acetylcholine receptor in reconstituted membranes. Xth international symposium on cholinergic mechanisms. From Torpedo electric organ to human brain: fundamental and applied aspects.. 432-433. 1998
- Lipid-protein interactions in reconstituted membranes containing nicotinicacetylcholine receptor . Spectroscopy of Biological Molecules: Modern Trends. 339-340. 1997
congress communication