Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

SAEZ VALERO, JAVIER

Person (Active)

Positions

Catedrático/a de Universidad, Bioquímica y Biología Molecular 2017 -
PDI INVESTIGADOR, Instituto de Neurociencias 2008 -
Profesor Titular Universidad, Bioquímica y Biología Molecular 2009 - 2017
Profesor/a Titular Universidad, Bioquímica y Biología Molecular 2009 - 2017
Profesor/a Contratado/a Doctor/a, Bioquímica y Biología Molecular 2006 - 2009
PDI INVESTIGADOR, Instituto de Neurociencias 2003
Profesor Asociado, Farmacología, Pediatría y Química Orgánica 2001

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selected publications

academic article
- ADAM10 gene variants in AD patients and their relationship to CSF protein levels. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-12. 2023
- BACE2 beyond ß-processing of APP, its neuroprotective role in cerebrovascular endothelium. JOURNAL OF NEUROCHEMISTRY. 887-890. 2023
- Presenilin 1 modulates acetylcholinesterase trafficking and maturation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-18. 2023
- Transient Changes in the Plasma of Astrocytic and Neuronal Injury Biomarkers in COVID-19 Patients without Neurological Syndromes. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-12. 2023
- Altered Balance of Reelin Proteolytic Fragments in the Cerebrospinal Fluid of Alzheimer's Disease Patients. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-16. 2022
- Apolipoprotein E imbalance in the cerebrospinal fluid of Alzheimer's disease patients. ALZHEIMERS RESEARCH & THERAPY. 1-19. 2022
- Serum Angiotensin-Converting Enzyme 2 as a Potential Biomarker for SARS-CoV-2 Infection and Vaccine Efficacy. FRONTIERS IN IMMUNOLOGY. 1-10. 2022
- La proteína ACE2 podría alertar de la gravedad del covid-19. THE CONVERSATION. 1-2. 2021
- Plasma ACE2 species are differentially altered in COVID-19 patients.. FASEB J. 21745-21746. 2021
- Relation between Alpha-Synuclein and Core CSF Biomarkers of Alzheimer¿s Disease. MEDICINE. 1-9. 2021
- Soluble ß-amyloid oligomers induce a P2X2 receptor increase that potentiate the neurotoxicity in Alzheimer¿s disease. BIOMEDICINE & PHARMACOTHERAPY. 1-15. 2021
- The apolipoprotein receptor LRP3 compromises APP levels. ALZHEIMERS RESEARCH & THERAPY. 1-17. 2021
- Alpha-Secretase nonsense mutation (ADAM10 Tyr167*) in familial Alzheimer's disease. ALZHEIMERS RESEARCH & THERAPY. 1-9. 2020
- Amyloid precursor protein glycosylation is altered in the brain of patients with Alzheimer's disease.. ALZHEIMERS RESEARCH & THERAPY. 1-15. 2020
- Elevated plasma reelin levels in autistic children. FRONTIERS IN PSYCHIATRY. 1-6. 2020
- Tau phosphorylation by glycogen synthase kinase 3beta modulates AChE expression. JOURNAL OF NEUROCHEMISTRY. 1-15. 2020
- Characterization of cerebrospinal fluid BACE1 species. MOLECULAR NEUROBIOLOGY. 8603-8616. 2019
- Measurement of CSF alpha-synuclein improves early differential diagnosis of mild cognitive impairment due to Alzheimer's disease.. JOURNAL OF NEUROCHEMISTRY. 218-230. 2019
- Pre-analytical stability of novel cerebrospinal fluid biomarkers. CLINICA CHIMICA ACTA. 204-211. 2019
- CSF-ApoER2 fragments as a read-out of reelin signaling: distinct patterns in sporadic and autosomal-dominant Alzheimer disease. CLINICA CHIMICA ACTA. 6-11. 2018
- Decreased circulating ErbB4 ectodomain fragments as a read-out of impaired signaling function in amyotrophic lateral sclerosis. NEUROBIOLOGY OF DISEASE. 428-438. 2018
- Decreased generation of C-terminal fragments of ApoER2 and increased reelin expression in Alzheimer¿s disease. FASEB J. 3536-3546. 2018
- Levels of ADAM10 are reduced in Alzheimer¿s disease CSF. JOURNAL OF NEUROINFLAMMATION. 1-9. 2018
- Alterations in the balance of amyloid precursor protein species in the cerebrospinal fluid of Alzheimer¿s disease patients. JOURNAL OF ALZHEIMERS DISEASE. 1281-1291. 2017
- C-terminal fragments of the amyloid precursor protein in cerebrospinal fluid as potential biomarkers for Alzheimer disease. SCIENTIFIC REPORTS. 1-7. 2017
- Inhibition of gamma-secretase leads increase level of presenilin-1. MOLECULAR NEUROBIOLOGY. 1-12. 2017
- Neuromuscular junction impairment in Amyotrophic Lateral Sclerosis: reassessing the role of Acetylcholinesterase. FRONTIERS IN MOLECULAR NEUROSCIENCE. 1-8. 2017
- The ß-amyloid peptide2 compromises Reelin signaling in Alzheimer¿s disease. SCIENTIFIC REPORTS. 1-11. 2017
- Cerebrospinal fluid Presenilin-1 increases at asymptomatic stage in genetically determined Alzheimer¿s disease. MOLECULAR NEURODEGENERATION. 1-11. 2016
- HNK-1 carrier glycoproteins are decreased in the Alzheimer¿s disease brain. MOLECULAR NEUROBIOLOGY. 1-12. 2016
- Increased Expression of Readthrough Acetylcholinesterase Variants in the Brains of Alzheimer's Disease Patients.. JOURNAL OF ALZHEIMERS DISEASE. 831-841. 2016
- Reelin in Alzheimer's disease, increased levels but impaired signaling: when more is less. JOURNAL OF ALZHEIMERS DISEASE. 403-416. 2016
- Heteromers of amyloid precursor protein in cerebrospinal fluid. MOLECULAR NEURODEGENERATION. 2015
- Transmembrane amyloid-related proteins in CSF as potential biomarkers for Alzheimers disease. FRONTIERS IN NEUROLOGY. 2015
- Validation of a quantitative cerebrospinal fluid alpha-synuclein assay in a European-wide interlaboratory study. NEUROBIOLOGY OF AGING. 2587-2596. 2015
- Acetylcholinesterase modulates Presenilin-1 levels and gamma-secretase activity. JOURNAL OF ALZHEIMERS DISEASE. 911-924. 2014
- Acetylcholinesterase protein level is preserved in the Alzheimer¿s brain. JOURNAL OF MOLECULAR NEUROSCIENCE. 446-453. 2014
- ApoER2 processing by presenilin-1 modulates reelin expression.. FASEB J. 1543-1554. 2014
- Presenilin-1 influences processing of the acetylcholinesterase membrane anchor PRiMA. NEUROBIOLOGY OF AGING. 1526-1536. 2014
- Quantification of the transcripts encoding different forms of AChE in various cell types: real-time PCR coupled with standards in revealing the copy number. JOURNAL OF MOLECULAR NEUROSCIENCE. 461-468. 2014
- Beta-amyloid impairs Reelin signaling. PLOS ONE. 1-10. 2013
- CSF Presenilin-1 complexes are increased in Alzheimer¿s disease. ACTA NEUROPATHOLOGICA COMMUNICATIONS. 1-13. 2013
- Identification of a 31-bp deletion in the RELN gene causing lissencephaly with cerebellar hypoplasia in sheep. PLOS ONE. 2013
- Altered expression of brain acetylcholinesterase in FTDP-17 human tay trangenic mice. NEUROBIOLOGY OF AGING. 624-634. 2012
- Readthrough acetylcholinesterase is increased in human liver cirrhosis. PLOS ONE. 1-7. 2012
- Recommendations to standardize Pre-analytical confounding factors in Alzheimer's and Parkinson's disease CSF biomarkers: an update. BIOMARKERS IN MEDICINE. 419-430. 2012
- Altered expression of brain acetylcholinesterase in FTDP-17 human tau transgenic mice . NEUROBIOLOGY OF AGING. 1-12. 2011
- Changes in acetylcholinesterase expression are associated with altered presenilin-1 levels. NEUROBIOLOGY OF AGING. 1-11. 2011
- Revisiting the role of acetylcholinesterase in Alzheimer¿s disease: cross-talk with P-tau and ß-amyloid. FRONTIERS IN MOLECULAR NEUROSCIENCE. 1-9. 2011
- Altered glycosylation of Reelin in Alzheimer's disease is induced by ß-amyloid. NEUROBIOLOGY OF DISEASE. 682-691. 2010
- Altered levels of acetylcholinesterase in Alzheimer plasma. PLOS ONE. 8701-11. 2010
- beta-amyloid controls altered Reelin expression and processing in Alzheimer's disease. NEUROBIOLOGY OF DISEASE. 682-691. 2010
- Association between acetylcholinesterase and beta-amyloid peptide in Alzheimer¿s cerebrospinal fluid. CHEMICO-BIOLOGICAL INTERACTIONS. 209-215. 2008
- Brain cholinergic impairment in liver failure. BRAIN. 2946-2956. 2008
- Presenilin-1 interacts with acetylcholinesterase and alters its enzymatic activity and glycosylation. MOLECULAR AND CELLULAR BIOLOGY. 2908-2919. 2008
- Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of humans with cirrhosis. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 766-775. 2008
- Cerebrospinal fluid acetylcholinesterase changes after treatment with donepezil in patients with Alzheimer¿s disease. JOURNAL OF NEUROCHEMISTRY. 1701-1711. 2007
- Glutamate-induced activation of nitric oxide synthase is impaired in cerebral cortex in vivo rats with chronic liver failure . JOURNAL OF NEUROCHEMISTRY. 51-64. 2007
- Reelin is overexpressed in the liver and plasma of bile duct ligated rats and its levels and glycosylation are altered in plasma of human with cirrhosis. INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 2007
- Altered glycosylation of acetylcholinesterase in Creutzfeldt-Jakob disease. JOURNAL OF NEUROCHEMISTRY. 97-104. 2006
- Altered glycosylation of acetylcholinesterase in the Creutzfeldt-Jakob cerebrospinal fluid. JOURNAL OF MOLECULAR NEUROSCIENCE. 65-66. 2006
- Brain Edema and Inflammatory Activation in Bile Duct Ligated Rats With Diet-Induced Hyperammonemia: A Model of Hepatic Encephalopathy in Cirrhosis. HEPATOLOGY. 1257-1266. 2006
- Changes in Liver and Plasma Acetylcholinesterase in Rats With Cirrhosis induced by Bile Duct Ligation. HEPATOLOGY. 444-453. 2006
- Nogo-A and Nogo receptor expression in the human hippocampus in normal aging and Alzheimer¿s disease. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY. 433-444. 2006
- Reelin expression and glycosylation patterns are altered in Alzheimer. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 5573-5578. 2006
- Bile duct ligation plus hyperammonemia in rats reproduces the alterations in the modulation of soluble guanylate cyclase by nitric oxide in brain of cirrhotic patients.. NEUROSCIENCE. 435-443. 2005
- Intraperitoneal administration of 340 kDa human plasma butyrylcholinesterase increases the level of the enzyme in the cerebrospinal fluid of rats. NEUROSCIENCE LETTERS. 93-98. 2005
- Acetylcholinesterase activation in organotypic hippocampal slice cultures deprived of oxygen and glucose. NEUROSCIENCE LETTERS. 123-125. 2003
- Acetylcholinesterase activation in organotypic rat hippocampal slice cultures, deprived of oxygen and glucose. NEUROSCIENCE LETTERS. 123-125. 2003
- Acetylcholinesterase activity an molecular isoform distribution are altered after focal cerebral ischemia. MOLECULAR BRAIN RESEARCH. 240-244. 2003
- Acetylcholinesterase activity and molecular isoform distribution are altered after focal cerebral ischemia.. BRAIN RESEARCH. 240-244. 2003
- Acetylcholinesterase is increased in mouse neuronal and astrocyte cultures after treatment with ß-amyloid peptides. BRAIN RESEARCH. 283-286. 2003
- Acetylcholinesterase is increases in mouse neuronal and astrocyte cultures after treatment with beta-amyloid peptides. BRAIN RESEARCH. 283-286. 2003
- Acetylcholinesterase level and molecular isoforms are altered in brain of Reelin Orleans mutant mice. JOURNAL OF NEUROCHEMISTRY. 773-779. 2003
- Altered levels of cerebrospinal fluid reelin in Frontotemporal dementia and Alzheimer¿s disease. JOURNAL OF NEUROSCIENCE RESEARCH. 132-136. 2003
- Altered levels of cerebrospinal fluid reelin in frontotemporal demential and althzeimers desease. JOURNAL OF NEUROSCIENCE RESEARCH. 132-136. 2003
- Glycosylation of Acetylcholinesterase and Butyrylcholinesterease Changes as a Function of the Duration of Alzheimer¿s Disease. JOURNAL OF NEUROSCIENCE RESEARCH. 520-523. 2003
- Glycosylation of acetylcholinesterase and butyrylcholinesterase changes as a function of the duration of Alzheimer¿s disease . JOURNAL OF NEUROSCIENCE RESEARCH. 520-526. 2003
- Altered glycosylation of acetylcholinesterase in APP (SW) Tg2576 transgenic mice occurs prior to amyloid plaque deposition.. JOURNAL OF NEUROCHEMISTRY. 441-448. 2002
- Changes in molecular isoform distribution of acetylcholinesterase in rat cortex and cerebrospinal fluid after intracerebroventricular administration of amyloid beta-peptide.. NEUROSCIENCE LETTERS. 199-202. 2002
- Acetylcholinesterase anch butynylcholinesterase glycoforms are biomarkers of Alzheimer's disease. JOURNAL OF ALZHEIMER'S DISEASE. 323-328. 2001
- Acetylcholinesterase and butyrylcholinesterase glycoforms are biomarkers of Alzheimer¿s disease. JOURNAL OF ALZHEIMER'S DISEASE. 323-328. 2001
- Alteración en el patrón de formas moleculares de acetilcolinesterasa en la corteza de ratas tras administración intracerebroventrícular de beta- amioloide 25-35.. REVISTA DE NEUROLOGIA. 2001
- Altered glycosylation of cerebrospinal fluid butyrylcholinesterase in Alzheimer's disease.. BRAIN RESEARCH. 247-250. 2001
- Decreased wheat germ aglutining- reactive glycoproteins in the cerebrospinal fluid of alzheimer's disease patients.. PROC. AUST. NEUROSCIENCIE. 2001
- Decreased wheat germ aglutining- reactive glycoproteins in the cerebrospinal fluid of alzheimer's disease patients.. JOURNAL OF NEUROCHEMISTRY. 1022-1026. 2001
- Idenfification of cholinesterase forms consisting of acetyl- and butyrylcholinesterase subnits in human glioma.. NEUROSCIENCE. 199-208. 2001
book
- Neuroeducacion Alimentaria. LIMENCOP. 2024
chapter
- Advancements of nanocarriers for brain targeting and limitations in clinical translation. Nanocarriers in Neurodegenerative Disorders. 1-12. 2024
- Alzheimer's Disease and Reelin. Reelin Glycoprotein, Biology, Structure and Roles in Health and Disease. 401-409. 2008
- Altered glycosylation of acetylcholinesterase in the Alzheimer disease brain: involvement of alfa7 nicotinic acetylcholine receptors. Recent Progress in Alzheimer's and Parkinson's Diseases. 243-247. 2005
- Increased levels of a minor glycoform of acetylcholinesterase in Alzheimer¿s disease brain and cerebrospinal fluid. Alzheimer's Disease : Advances in Etiology, Pathogenesis and Therapeutics . 293-301. 2001
congress communication
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