Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

NEIRA FALEIRO, JOSE LUIS

Person (Active)

Positions

Catedrático/a de Universidad, Agroquímica y Medio Ambiente 2010 -
PDI INVESTIGADOR, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2018 -
MIEMBRO, Reconocimiento Molecular e Ingeniería y Biofísica de Proteínas 2013 -
PDI INVESTIGADOR, Instituto de Biología Molecular y Celular 2004 - 2018
Profesor/a Titular Universidad, Agroquímica y Medio Ambiente 2007 - 2010
Profesor Titular Universidad, Agroquímica y Medio Ambiente 2002 - 2007
Profesor Interino Titular Unv., Agroquímica y Medio Ambiente 2000 - 2002
Profesor Titular Universidad, Ciencia de Materiales, Óptica y Tecnología Electrónica 1999 - 2000
Profesor Interino Titular Unv., Ciencia de Materiales, Óptica y Tecnología Electrónica 1999 - 2000
Profesor Titular Universidad, CC TECNOLOGIA MATERIALES 1999
Profesor Interino Titular Unv., CC TECNOLOGIA MATERIALES 1999

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selected publications

academic article
- Citrullinating enzyme PADI4 and transcriptional repressor RING1B bind in cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 133163-133187. 2024
- Development of an efficient NUPR1 inhibitor with anticancer activity. SCIENTIFIC REPORTS. 29515-29535. 2024
- Isolated auto-citrullinated regions of PADI4 associate to the intact protein without altering their disordered conformation. BIOPHYSICAL CHEMISTRY. 107288-107302. 2024
- Structure and dynamics of the cyanobacterial regulator SipA. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 109943-109953. 2024
- Targeting NUPR1-dependent stress granules formation to induce synthetic lethality in KrasG12D-driven tumors. EMBO MOLECULAR MEDICINE. 475-505. 2024
- Three-dimensional solution structure, dynamics and binding of thioredoxin m from Pisum sativum. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 129781-129793. 2024
- Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP. BIOMOLECULES. 561-578. 2024
- Conformational Stability of the N-Terminal Region of MDM2. MOLECULES. 7578-7583. 2023
- Folding of the nascent polypeptide chain of a histidine phosphocarrier protein in vitro. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 109538-109550. 2023
- Intrinsically Disordered Chromatin Protein NUPR1 Binds to the Enzyme PADI4. JOURNAL OF MOLECULAR BIOLOGY. 168033-168054. 2023
- New insights into cancer: MDM2 binds to the citrullinating enzyme PADI4. PROTEIN SCIENCE. 4723-4756. 2023
- Paul F. Fitzpatrick: A life of editorial duties and elucidating the mechanism of enzyme action. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 109635-109641. 2023
- The armadillo-repeat domain of Plakophilin 1 binds to human enzyme PADI4. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 10101-10111. 2023
- The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PAD14 in cancer cells. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 1-14. 2023
- The intrinsically disordered, epigenetic factor RYBP binds to the citrullinating enzyme PADI4 in cancer cells.. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2023
- Biochemical and biophysical characterization of PADI4 supports its involvement in cancer. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1-16. 2022
- An N-terminal half fragment of the histidine phosphocarrier protein, HPr, is disordered but binds to HPr partners and shows antibacterial properties. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 1-11. 2021
- Residual helicity at the active site of the histidine phosphocarrier, HPr, modulates binding affinity to its natural partners. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-18. 2021
- The armadillo-repeat domain of plakophilin 1 binds the C-terminal sterile alpha motif (SAM) of p73. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 129914-129926. 2021
- The muscle-relaxing C-terminal peptide from troponin I populates a nascent helix, facilitating binding to tropomyosin with a potent therapeutic effect. JOURNAL OF BIOLOGICAL CHEMISTRY. 1-18. 2021
- Intrinsically disordered proteins in biology: One for all, all for one.. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 10832-10835. 2020
- A group II intron-encoded protein interacts with the cellular replicative machinery through the ß-sliding clamp.. NUCLEIC ACIDS RESEARCH. 7605-7617. 2019
- Dendrimers as Competitors of Protein-Protein Interactions of the Intrinsically Disordered Nuclear Chromatin Protein NUPR1. BIOMACROMOLECULES. 2567-2576. 2019
- Ligand-based design identifies a potent NUPR1 inhibitor exerting anticancer activity via necroptosis.. JOURNAL OF CLINICAL INVESTIGATION. 2500-2513. 2019
- The C-terminal SAM domain of p73 binds to the N terminus of MDM2.. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS. 760-770. 2019
- An introduction to the special issue on biomolecular NMR. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1-2. 2017
- Enhanced vulnerability of human proteins towards disease-associated inactivation through divergent evolution. HUMAN MOLECULAR GENETICS. 3531-3534. 2017
- Identification of a Drug Targeting an Intrinsically Disordered Protein Involved in Pancreatic Adenocarcinoma. SCIENTIFIC REPORTS. 39732-39747. 2017
- Intrinsically disordered chromatin protein NUPR1 binds to the C-terminal region of Polycomb RING1B. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 1-20. 2017
- Intrinsically disordered inhibitor of glutamine synthetase is a functional protein with random-coil-like pKa values. PROTEIN SCIENCE. 1105-1115. 2017
- Site-to-site interdomain communication may mediate different loss-of-function mechanisms in a cancer-associated NQO1 polymorphism. SCIENTIFIC REPORTS. 44532-44550. 2017
- The PipX Protein, When Not Bound to Its Targets, Has Its Signaling C¿Terminal Helix in a Flexed Conformation. BIOCHEMISTRY. 3211-3224. 2017
- The isolated, twenty-three-residue-long, N-terminal region of the glutamine synthetase inactivating factor binds to its target. BIOPHYSICAL CHEMISTRY. 1-9. 2017
- Trifluoroethanol-induced conformational transition of the C-terminal sterile alpha motif (SAM) of human p73. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1-9. 2017
- Determinants of the pKa values of ionizable residues in an intrinsically disordered protein... ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 18-27. 2016
- Dissecting the Binding between Glutamine Synthetase and Its Two Natively Unfolded Protein Inhibitors.. BIOCHEMISTRY. 3370-3382. 2016
- Human COA3 Is an Oligomeric Highly Flexible Protein in Solution.. BIOCHEMISTRY. 6209-6220. 2016
- The Monomeric Species of the Regulatory Domain of Tyrosine Hydroxylase Has a Low Conformational Stability.. BIOCHEMISTRY. 3418-3431. 2016
- The chondroitin sulfate/dermatan sulfate 4-O-endosulfatase from marine bacterium Vibrio sp FC509 is a dimeric species: Biophysical characterization of an endosulfatase.. BIOCHIMIE. 85-95. 2016
- Biophysical analysis of the MHR motif in folding and domain swapping of the HIV capsid protein C-terminal domain.. BIOPHYSICAL JOURNAL. 338-349. 2015
- Cysteine Mutational Studies Provide Insight into a Thiol-Based Redox Switch Mechanism of Metal and DNA Binding in FurA from Anabaena sp. PCC 7120.. ANTIOXIDANTS & REDOX SIGNALING. 236-239. 2015
- Functional Characterization of Nupr1L, A Novel p53-Regulated Isoform of the High-Mobility Group (HMG)-Related Protumoral Protein Nupr1.. JOURNAL OF CELLULAR PHYSIOLOGY. 2936-2950. 2015
- The carboxy-terminal domain of Erb1 is a seven-bladed ß-propeller that binds RNA.. PLOS ONE. 1234. 2015
- BIOCHEMICAL AND MUTATIONAL STUDIES OF ALLANTOINASE FROM BACILLUS LICHENIFORMIS CECT 20T. BIOCHIMIE. 178-188. 2014
- EVIDENCE SUPPORTING THE EXISTENCE OF A NUPR1-LIKE FAMILY OF HELIX-LOOP-HELIX CHROMATIN PROTEINS RELATED TO, YET DISTINCT FROM, AT HOOK-CONTAINING HMG PROTEINS. JOURNAL OF MOLECULAR MODELING. 20-40. 2014
- Electrostatic Effects in the Folding of the SH3 Domain of the c-Src Tyrosine Kinase:. PLOS ONE. 20-30. 2014
- STRUCTURAL DISSECTION OF THE C-TERMINAL STERILE ALPHA-MOTIF (SAM) OF. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 133-142. 2014
- THE ISOLATED N TERMINUS OF RING1B IS A. PROTEIN ENGINEERING DESIGN & SELECTION. 1-11. 2014
- An N-terminally truncated mutant of human chemokine CXCL14 has biological activity.. PROTEIN AND PEPTIDE LETTERS. 955-967. 2013
- BRMS151-98 and BRMS151-84 are crystal oligomeric coiled coils with different oligomerization states, which behave as disordered protein fragments in solution.. JOURNAL OF MOLECULAR BIOLOGY. 2147-2163. 2013
- Deciphering the Binding between Nupr1 and MSL1 and Their DNA-Repairing Activity.. PLOS ONE. 78101-78125. 2013
- Falling down: landscape and kinetics of one-dimensional protein folding.. STRUCTURE. 1905-1907. 2013
- NMR as a tool to identify and characterize protein folding intermediates. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 90-99. 2013
- NS3 protease from hepatitis C virus: biophysical studies on an intrinsically disordered protein domain.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 13282-13306. 2013
- Protein folding: a Prague cemetery. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS. 1-3. 2013
- The histidine-phosphocarrier protein of the phosphoenolpyruvate: sugar phosphotransferase system of Bacillus sphaericus self-associates.. PLOS ONE. 69307-69322. 2013
- Mutation of Ser-50 and Cys-66 in Snapin Modulates Protein Structure and Stability. BIOCHEMISTRY. 3470-3484. 2012
- Conformational Stability and Biophysical Properties of the Eukaryotic Thioredoxins of Pisum Sativum Are Not Family-Conserved. PLOS ONE. 1-16. 2011
- Larger helical populations in peptides derived from the dimerization helix of the capsid protein of HIV-1 results in peptide binding towards regions other than the "hotspot" interface. BIOMACROMOLECULES. 3252-3264. 2011
- Nucleotide-induced conformational transitions in the CBS domain protein MJ0729 of Methanocaldococcus jannaschii. PROTEIN ENGINEERING DESIGN & SELECTION. 161-169. 2011
- Rationally Designed Interfacial Peptides are Efficient in vitro Inhibitors of HIV-1 Capsid Assembly with Antiviral Activity. PLOS ONE. 1-14. 2011
- Nucleotide-induced conformational transitions in the CBS domain protein MJ0729 of Methanocaldococcus jannaschii.. PROTEIN ENGINEERING DESIGN & SELECTION. 1-9. 2010
- The N-terminal domain of the enzyme I is a monomeric well-folded protein with a low conformational stability and residual structure in the unfolded state.. PROTEIN ENGINEERING DESIGN & SELECTION. 729-742. 2010
- The basic helix-loop-helix region of human neurogenin 1 is a monomeric natively unfolded protein which forms a ¿fuzzy¿ complex upon DNA binding. BIOCHEMISTRY. 1577-1589. 2010
- The CBS-domain protein MJ0729 of Methanococcus jannaschii is a thermostable protein with pH-dependent homooligomeric species.. BIOCHEMISTRY. 2760-2776. 2009
- Metal-triggered changes in the stability and secondary structure of a tetrameric dihydropyrimidinase: A biophysical characterization. BIOPHYSICAL CHEMISTRY. 42-52. 2008
- N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.. JOURNAL OF BIOLOGICAL CHEMISTRY. 18076-18085. 2008
- The family 52 ß-xylosidase from Geobacillus stearothermophilus is a dimer: Structural and biophysical characterization of a glycoside hydrolase. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 1924-1934. 2008
- Dynamics of tryptophan in the histidine-containing phosphocarrier protein of Streptomyces coelicolor: evidence of multistate equilibrium unfolding. BIOCHEMISTRY. 7252-7260. 2007
- FLEXIBILITY IN HIV-1 ASSEMBLY SUBUNITS: SOLUTION STRUCTURE OF THE MONOMERIC C-TERMINAL DOMAIN OF THE CAPSID PROTEIN.. BIOPHYSICAL JOURNAL. 1264-1276. 2007
- ISOLATION AND CHARACTERIZATION OF A THERMOSTABLE ¿Ò-XYLOSIDASE IN THE THERMOPHILIC BACTERIUM GEOBACILLUS PALLIDUS. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS. 510-518. 2007
- THE HELICAL STRUCTURE PROPENSITY OF THE FIRST HELIX OF THE HISTIDINE PHOSPHOCARRIER PROTEIN OF STREPTOMYCES COELICOLOR. PROTEIN AND PEPTIDE LETTERS. 281-290. 2007
- THE ISOLATED C-TERMINAL DOMAIN OF RING1B IS A DIMER MADE OF STABLE WELL-STRUCTURED MONOMERS.. BIOCHEMISTRY. 12764-12776. 2007
- BINDING OF THE C-TERMINAL DOMAIN OF THE HIV-1 CAPSID PROTEIN TO LIPID MEMBRANES: A BIOPHYSICAL CHARACTERIZATION.. BIOCHEMICAL JOURNAL. 345-353. 2006
- Biophysical characterization of the Enzyme I of the Streptomyces coelicolor phosphoenolpyruvate: sugar phosphor.-transferase system. BIOPHYSICAL JOURNAL. 4592-4604. 2006
- FILLING SMALL, EMPTY PROTEIN CAVITIES: STRUCTURAL AND ENERGETIC CONSEQUENCES. JOURNAL OF MOLECULAR BIOLOGY. 701-712. 2006
- P8 AND PROTHYMOSIN ALPHA: UNITY IS STRENGTH.. CELL RESEARCH. 829-830. 2006
- REGULATION OF APOPTOSIS BY THE P8/PROTHYMOSIN ALPHA COMPLEX. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 2671-2676. 2006
- SITE-DIRECTED MUTAGENESIS INDICATES AN IMPORTANT ROLE OF CYSTEINES 76 AND 181 IN THE CATALYSIS OF HYDANTOIN RACEMASE FROM SINORHIZOBIUM MELILOTI. PROTEIN SCIENCE. 2729-2738. 2006
- AN EXTENSIVE THERMODYNAMIC CHARACTERIZATION OF THE DIMERIZATION DOMAIN OF THE HIV-1 CAPSID PROTEIN. PROTEIN SCIENCE. 2387-2404. 2005
- HPR AS A MODEL IN PROTEIN FOLDING AND STABILITY STUDIES. PROTEIN AND PEPTIDE LETTERS. 123-137. 2005
- STRUCTURE AND CONFORMATIONAL STABILITY OF THE ENZYME I OF STREPTOMYCES COELICOLOR EXPLORED BY FTIR AND CIRCULAR DICHROISM. BIOPHYSICAL CHEMISTRY. 229-233. 2005
- THE CONFORMATIONAL STABILITY AND THERMODYNAMICS OF FUR A (FERRIC UPTAKE REGULATOR) FROM ANABAENA SP. PCC 7119. BIOPHYSICAL JOURNAL. 4188-4200. 2005
- Unfolding and Refolding in Vitro of a Tetrameric, alpha-Helical Membrane Protein: The Prokaryotic Potassium Channel KcsA. BIOCHEMISTRY. 14344-14352. 2005
- THE CONFORMATIONAL STABILITY OF THE STREPTOMYCES COELICOLOR HISTIDINE-PHOSPHOCARRIER PROTEIN. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2165-2181. 2004
- THE DIMERIZATION DOMAIN OF THE HIV-1 CAPSID PROTEIN BINDS A CAPSID PROTEIN-DERIVED PEPTIDE: A BIOPHYSICAL CHARACTERIZATION. PROTEIN SCIENCE. 1512-1523. 2004
- Binding of the C-terminal Sterile {alpha} Motif (SAM) Domain of Human p73 to Lipid Membranes. JOURNAL OF BIOLOGICAL CHEMISTRY. 46878-46885. 2003
- STRUCTURE AND DYNAMICS OF THE POTATO CARBOXYPEPTIDASES INHIBITOR BY 1H AND 15N. PROTEINS-STRUCTURE FUNCTION AND GENETICS. 410-422. 2003
- THE INACTIVATING FACTOR OF GLUTAMINE SYNTHTHASE IS A ¿NATIVELY UNFOLDED¿ PROTEIN. PROTEIN SCIENCE. 1443-1454. 2003
- THERMODYNAMIC DISSECTION OF A LOW AFFINITY PROTEIN-PROTEIN INTERFACE INVOLVED IN HUMAN IMMUNODEFICIENCY VIRUS ASSEMBLY.. JOURNAL OF BIOLOGICAL CHEMISTRY. 27923-27929. 2003
- The histidine-phosphocarrier protein from Streptomyces coelicolor folds via a partially folded species at low pH. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2254-2267. 2003
- The histidine-phosphocarrier protein of Streptomyces coelicolor folds by a partially folded species at low pH. EUROPEAN JOURNAL OF BIOCHEMISTRY. 2254-2267. 2003
- BIOCHEMICAL CHARACTERIZATION OF THE RECOMBINANT FUR PROTEIN FROM ANABAENA PCC7119; FACTORS AFFECTING ITS OLIGOMERIZATION STATE.. BIOCHEMICAL JOURNAL. 315-322. 2002
- Equilibrium unfolding of the C-terminal SAM domain of P73.. BIOCHEMISTRY. 5743-5753. 2002
- ¿Equilibrium Unfolding of the C-Terminal SAM Domain of p73 . BIOCHEMISTRY. 5743-5753. 2002
- Human p8 is a HMG-I/Y protein with DNA binding activity enhanced by phosphorilation.. JOURNAL OF BIOLOGICAL CHEMISTRY. 2742-2751. 2001
- Hydrogen exchange of the tetramerization domain of the human tumour supressor p53 probed by denaturants and temperature.. EUROPEAN JOURNAL OF BIOCHEMISTRY. 4868-4877. 2001
- Three-dimensional solution structure and stability of thioredoxin m from spinach.. BIOCHEMISTRY. 15246-15256. 2001
book
- NMR FOR CHEMISTS AND BIOLOGISTS. SPRINGER. 2013
chapter
- FLUORESCENCE, CIRCULAR DICHROISM AND MASS SPECTROMETRY AS TOOLS TO STUDY VIRUS STRUCTURE. STRUCTURE AND PHYSICS OF VIRUSES: AN INTEGRATED TEXTBOOK. 177-202. 2013
- NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY TO STUDY VIRUS STRUCTURE. STRUCTURE AND PHYSICS OF VIRUSES: AN INTEGRATED TEXTBOOK. 145-176. 2013
- Y LAS PUERTAS DEL REINO DE LAS MARAVILLAS SE ABRIERON DE GOLPE. Cuéntame qué haces en Ciencia. 12-23. 2005
- Sacra Red. Cuéntame qué haces en Ciencia. 37-46. 2004
- Ingeniería y diseño de proteínas. Cuéntame qué haces en Ciencia. 487-516. 2003
- Plegamiento de proteínas y enfermedades relacionadas. Cuéntame qué haces en Ciencia. 201-232. 2003
congress communication