selected publications
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academic article
- 1¿(2¿,5¿-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1- propanone (RGM079): A Positive Allosteric Modulator of ¿7 Nicotinic Receptors with Analgesic and Neuroprotective Activity. ACS CHEMICAL NEUROSCIENCE. 3900-3909. 2019
- A Retino-retinal Projection Guided by Unc5c Emerged in Species with Retinal Wave. CURRENT BIOLOGY. 1149-1160. 2019
- Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila. EMBO JOURNAL. 1-15. 2019
- Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of ¿7 nicotinic receptors with analgesic activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 157-165. 2018
- Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of alpha 7 nicotinic receptors with analgesic activity. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 1-10. 2017
- Noise Maps for Quantitative and Clinical Severity Towards Long-Term ECG Monitoring. SENSORS. 1-23. 2017
- 1,3-diphenylpropan-1-ones as allosteric modulators of alpha7 nACh receptors with analgesic and antioxidant properties. FUTURE MEDICINAL CHEMISTRY. 731-749. 2016
- N-benzylpiperidine derivatives as alpha7 nicotinic receptor antagonists. ACS CHEMICAL NEUROSCIENCE. 1157-1165. 2016
- Chalcones as positive allosteric modulators of a7 nicotinic acetylcholine receptors: A new target for a privileged structure. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 724-729. 2014
- Effect of Triazine Derivatives on Neuronal Nicotinic Receptors. ACS CHEMICAL NEUROSCIENCE. 683-689. 2014
- Expression and functional properties of ¿7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits. JOURNAL OF NEUROCHEMISTRY. 1-35. 2012
- A small cytoplasmic region adjacent to the fourth transmembrane segment of the alpha7 nicotinic receptor is essential for its biogenesis. FEBS LETTERS. 2477-2480. 2011
- Mutants of beta-strand beta3 and the loop B in the interface between alpha7 subunits of a homomeric acetylcholine receptor show functional and pharmacological alterations.. JOURNAL OF NEUROCHEMISTRY. 968-978. 2011
- Substitutions of amino acids in the pore domain of homomeric alpha7 nicotinic receptors for analogous residues present in heteromeric receptors modify gating, rectification and binding properties. JOURNAL OF NEUROCHEMISTRY. 40-49. 2011
- Role of loop 9 on the function of neuronal nicotinic receptors.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 654-659. 2010
- Role of the extracellular transmembrane domain interface in gating and pharmacology of a heteromeric neuronal nicotinic receptor. JOURNAL OF NEUROCHEMISTRY. 1036-1045. 2010
- The loop between beta-strands beta2 and beta3 and its interaction with the N-terminal alpha-helix is essential for biogenesis of alpha7 nicotinic receptors. JOURNAL OF NEUROCHEMISTRY. 103-111. 2010
- Binding-gating coupling in a nondesensitizing alpha7 nicotinic receptor. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 410-416. 2009
- Investigating the role of protein folding and assembly in cell-type dependent expression of alpha7 nicotinic receptors using a green fluorescent protein chimera. BRAIN RESEARCH. 7-16. 2009
- Role of the N-terminal alpha-helix in biogenesis of alpha7 nicotinic receptors. JOURNAL OF NEUROCHEMISTRY. 1399-1409. 2009
- Single channel study of the binding-gating coupling in the slowly desensitizing chimeric alpha7-5HT3A receptor. FEBS LETTERS. 1045-1051. 2009
- Interactions between loop 5 and beta-strand beta6¿ are involved in alpha7 nicotinic acetylcholine receptors channel gating. JOURNAL OF NEUROCHEMISTRY. 719-730. 2008
- Molecular characterization and localization of the RIC-3 protein, an effector of nicotinic acetylcholine receptor expression. JOURNAL OF NEUROCHEMISTRY. 617-627. 2008
- Cytoplasmic regions adjacent to the M3 and M4 transmembrane segments influence expression and function of alpha7 nicotinic acetylcholine receptors. A study with single amino acid mutants. JOURNAL OF NEUROCHEMISTRY. 406-415. 2007
- Non-charged amino acids from three different domains contribute to link agonist binding to channel gating in alpha7 nicotinic acetylcholine receptors.. JOURNAL OF NEUROCHEMISTRY. 725-735. 2007
- Improved gating of a chimeric alpha7-5HT3A receptor upon mutations at the M2-M3 extracellular loop. FEBS LETTERS. 256-260. 2006
- The Cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- Charged Amino Acids of the N-terminal Domain Are Involved in Coupling Binding and Gating in alpha7 Nicotinic Receptors . JOURNAL OF BIOLOGICAL CHEMISTRY. 6642-6647. 2005
- Dual role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors. . JOURNAL OF BIOLOGICAL CHEMISTRY. 27062-27068. 2005
- Mutations of a conserved lysine residue in the N-terminal domain of alpha7 nicotinic receptors affect gating and binding of nicotinic agonists. MOLECULAR PHARMACOLOGY. 1669-1677. 2005
- Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite. NEUROSCIENCE LETTERS. 144-149. 2005
- Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite. . NEUROSCIENCE LETTERS. 144-149. 2005
- The cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits.. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- Conservation within the RIC-3 gene family. Effectors of mammalian nicotinic acetylcholine receptor expression. JOURNAL OF BIOLOGICAL CHEMISTRY. 34411-34417. 2003
- Las sustancias elastoviscosas con efectos analgésicos en el dolor de las articulaciones reducen la actividad in vitro de los canales iónicos activados por estiramiento. REVISTA DE LA SOCIEDAD ESPAÑOLA DEL DOLOR. 419-429. 2003
- Effects of benzothiazepines on human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.. BRITISH JOURNAL OF PHARMACOLOGY. 183-192. 2002
- Effects of gingenoside Rg2 on human neuronal nicotinic acetylcholine receptors.. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1052-1059. 2002
- Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes.. EUROPEAN JOURNAL OF PHARMACOLOGY. 37-45. 2002
- Elastoviscous substances with analgesic effects on joint pain reduce stretch-activated ion channel activity "in vitro".. PAIN. 501-508. 2002
- Role of the large cytoplasmic loop of the alpha7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function.. BIOCHEMISTRY. 7931-7938. 2002
- Modulación de la transducción mecano-nociceptiva por sustancias viscoelásticas.. REV. NEUROL.. 660-660. 2001
- Multiple roles of the conserved residue arginine 209 in neuronal nicotinic receptors.. BIOCHEMISTRY. 8300-8306. 2001
- Papel del residuo conservado arginina 209 en los receptores nicotínicos neuronales.. NEUROLOGY. 2001
- Gating of alpha3beta4 neuronal nicotinic receptor can be controlled by the loop M2-M3 of both beta3 and beta4 subunits.. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 86-92. 1999
- A residue in the middle of the M2-M3 loop of the ß4 subunit specifically affects gating of neuronal nicotinic receptors. FEBS LETTERS. 89-92. 1998
- Neuronal nicotinic acetylcholine receptors on bovine chromaffin cells: cloning, expression, and genomic organization of receptor subunits.. JOURNAL OF NEUROCHEMISTRY. 488-497. 1997
- Role of the putative transmembrane segment M3 in gating of neuronal nicotinic receptors. BIOCHEMISTRY. 2709-2715. 1997
- A single residue in the M2-M3 loop is a major determinant of coupling between binding and gating in neuronal nicotinic receptors. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 6118-6123. 1996
- Acetylcholine receptor subunit formation requires compatibility between amino acid residues of the M1 and M2 transmembrane segments. FEBS LETTERS. 83-86. 1996
- alpha-Bungarotoxin-sensitive nicotinic receptors on bovine chromaffin cells: molecular cloning, functional expression, and alternative splicing of the a7 subunit. EUROPEAN JOURNAL OF NEUROSCIENCE. 647-665. 1995
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chapter
- Effects of elastoviscous solutions of hyluronan derivatives on mechanotransduction. Hyaluronan, Biomedical, Medcal and Clinical Aspects, Vol. 2.. 407-418. 2002
- Response of native stretch-activated ion channels of adult Xenopus Laevis oocytes to hylan solutions.. Hyaluronan Congress Proccedings of the symposium Hyaluron.. 2001
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congress communication
- A RETINO-RETINAL PROJECTION GUIDED BY UNC5C EMERGED IN SPECIES WITH RETINAL WAVES 2019
- A developmental threshold relating retinal and V1 areas predicts the structure of V1 Orientation Preference Maps. 2019
- A retino-retinal projection guided by Unc5c emerged in species with retinal waves 2019
- Morpho-dynamic changes of corneal cold sensory nerve fibers in the adult living mouse 2019
- Morpho-dynamic changes of corneal cold sensory nerve fibers in the adult living mouse. 2019
- VISUAL ORIENTATION MAPS IN FERRETS IS RESILIENT TO BRAIN INSULT DURING NEURODEVELOPMENT 2019
- deling of corneal cold sensory nerve fibers in the adult living mouse 2019
- Polyhydroxy diphenyl propanones as PAMs of the ¿7 nAChR with analgesic activity. Attempts to improve the PK profile 2018
- The Netrin receptor Unc5c controls the formation of the retino-retinal connection 2018
- INTO THE JAIL: STUDYING THE MORAL BEHAVIOR OF SOCIALLY CHALLENGED POPULATIONS 2017
- ON THE STABILITY OF THE POPULATION DISTRIBUTION OF MORAL BEHAVIOR 2017
- STATISTICAL WIRING OF VISUAL CORTICAL RECEPTIVE FIELDS AND MAPS 2017
- THE CURVE: INDIVIDUAL MORAL BEHAVIORS ARE EQUALLY DISTRIBUTED IN POPULATIONS FROM DIFFERENT COUNTRIES AND CULTURAL BACKGROUNDS 2017
- Thalamic influence on the statistical wiring of visual cortical receptive fields and maps. 863-864. 2017
- Clinical Severity of Noise in ECG. 641-644. 2016
- New allosteric modulators of ¿7 nicotinic receptors with analgesic and antioxidant properties 2015
- Pro-drug Approaches to New Allosteric Modulators of ¿7 nAChRs with Analgesic Activity 2015
- CYTOPLASMIC REGION CLOSE TO THE M4 TRANSMEMBRANE SEGMENT INFLUENCES THE EXPRESSION AND FUNCTION OF ALPHA7 NICOTINIC RECEPTORS. 102-102. 2007
- Dominios del receptor nicotínico implicados en la activación del canal iónico. 2007
- Gating of a7 nicotinic receptors from chromaffin cells: the role of domains near the agonist binding site. 2007
- Aminoácidos no cargados de tres dominios diferentes participan en la activación del receptor nicotínico alpha7 2006
- Charged and polar amino acids from three different domains are involved in gating of alpha7 nicotinic acetylcholine receptors 2006
- El papel del lazo 5 y otros dominios intermedios en la comunicación entre el sitio de unión de agonistas y el canal iónico del refceptor nicotínico alfa7 2006
- La inserción de una secuencia del loop C de la subunidad alfa1 del receptor nicotínico en la subunidad alfa5 reproduce el sitio de unión de alfa-bungarotoxina 2006
- Requisitos moleculares en la acción del modulador alostérico PNU-120596 sobre receptores nicotínicos neuronales alfa7 2006
- Ric3 incrementa la expresión superficial de receptores nicotínicos alfa7 modificando su equilibrio de inserción/internalización 2006
- The alpha7 nicotinic receptor from bovine chromaffin cells: a gating mechanism associated to charged and polar amino acids from three different domains 2006
- Un aminoácido próximo al dominio de unión de ligando en la quimera alfa7-5HT3 está implicado en el mecanismo de activación de los nAChRs 2006
- Aumento de la eficiencia del receptor quimérico alfa7-5HT3A al mutar el lazo extracelular M2-M3 2005
- El doble papel de la proteína RIC-3 en el transporte de los receptores nicotínicos y serotoninérgicos. 2005
- Electrostatic interactions link agonist binding to channel gating in the neuronal alpha7 nicotinic receptor. 2005
- Implicación funcional y farmacológica de un aminoácido del receptor nicotínico neuronal bovino alfa7 en el mecanismo de acoplamiento entre la unión de ligando y la apertura de la compuerta 2005
- Importancia de aminoácidos localizados en el segmento N-terminal de la gran región citoplásmica de la subunidad alfa7 en la expresión y función de receptores nicotínicos 2005
- La activación del canal del receptor nicotínico alfa7: un mecanismo asociado a tres dominios diferentes 2005
- Residuos específicos de la región citoplásmica de la subunidad 7 regulan diferencialmente la expresión funcional de receptores nicotínicos de acetilcolina. 2005
- Residuos específicos de la región citoplásmica de la subunidad alfa7 regulan diferencialmente la expresión funcional de receptores nicotínicos de acetilcolina 2005
- The role of the RIC-3 protein in trafficking of serotonin and nicotinic acetylcholine receptors 2005
- Aislamiento de tres nuevas proteínas que se asocian específicamente con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal 2003
- Efecto de la proteína Ric-3 sobre la expresión de los receptores nicotínicos neuronales. 2003
- Effects of an alkaloid from Flustra foliacea on recombinant human neuronal nicotinic acetylcholine receptors. 272-272. 2003
- Estudio de la potenciación de los receptores nicotínicos de acetilcolina neuronales humanos alfa4beta2 mediante un metabolito de la Flustra foliacea 2003
- Importancia del segmento c-terminal de la gran región citoplásmica de la subunidad alfa7 en la expresión funcional de receptores nicotínicos de acetilcolina 2003
- Influencia del segmeto C-terminal de la gran región citoplásmica de la subunidad alfa7 en la expresión funcional de receptores nicotínicos de acetilcolina. 2003
- La proteína RIC-3: un efector de la expresión de receptores nicotínicos neuronales. 2003
- The Ric-3 protein: an effector of nicotinic acetylcholine receptor expression 2003
- Trap: una nueva proteína que interacciona con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal 2003
- Efecto de los alcaloides de Flustra Foliacea en receptores nicotínicos neuronales humanos recombinantes. 2002
- Expresión funcional de receptores nicotínicos de acetilcolina: papel de la principal región citoplásmica de la subunidad alfa7 2002
- Identificación y caracterización de proteínas que interaccionan con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal. 2002
- Efectos del ginsenósido Rg2 sobre receptores nicotínicos neuronales humanos recombinantes. 2001
- Papel de la gran región citoplásmica de la subunidad alfa7 en la expresión funcional de receptores nicotínicos de acetilcolina 2000
- Interacciones de la nicotina y derivados del diltiazem en receptores nicotínicos neuronales humanos 2000
- Activación y modulación de receptores nicotínicos neuronales. 204-204. 1999