selected publications
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academic article
- Efficacy and safety of intramuscular administration of allogeneic adipose tissue derived and expanded mesenchymal stromal cells in diabetic patients with critical limb ischemia with no possibility of revascularization: study protocol for a randomized controlled double-blind phase II clinical trial (The NOMA Trial). TRIALS. 1-12. 2021
- AICAR stimulates the pluripotency of transcriptional complex inembryonic stem cells mediated by Pi3K, GSK3beta and beta catenin. ACS OMEGA. 20270-20282. 2020
- Adipose-derived mesenchymal stromal cells for the treatment of patients with severe SARS-CoV-2 pneumonia requiring mechanical ventilation. A proof of concept study. LANCET. 1-9. 2020
- Mesenchymal Stromal Cell-based therapies as promising treatments for muscle regeneration after snakebite envenoming. FRONTIERS IN IMMUNOLOGY. 2020
- Therapeutic potential of mesenchymal stem cells for cancer therapy. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 1-13. 2020
- A Role for the Host in the Roadmap to Diabetes Stem Cell Therapy. DIABETES. 1155-1157. 2019
- A refined characterisation of the NeoHepatocyte phenotype necessitates a reappraisal of the transdifferentiation hypothesis.. DIFFERENTIATION. 263-276. 2019
- Adipose mesenchymal stromal cells isolated from type 2 diabetic patients display reduced fibrinolytic activity. DIABETES. 4266-4269. 2019
- Adipose-derived mesenchymal stem cells (AdMSC) for the treatment of secondary-progressive multiple sclerosis: A triple blinded, placebo controlled, randomized phase I/II safety and feasibility study. PLOS ONE. 1958-95891. 2019
- An extra virgin olive oil rich diet intervention ameliorates the nonalcoholic steatohepatitis induced by a high-fat "Western-type" diet in mice. MOLECULAR NUTRITION & FOOD RESEARCH. 1-8. 2019
- Angiographic demonstration of Neoangiogenesis after intra-arterial infusion of autologous bone marrow mononuclear cells in diabetic patients with critical limb ischaemia. CELL TRANSPLANTATION. 1629-1639. 2019
- Bottlenecks in the Efficient Use of Advanced Therapy Medicinal Products Based on Mesenchymal Stromal Cells. STEM CELLS INTERNATIONAL. 1-12. 2019
- Cost-effective, safe and personalized cell therapy for critical limb ischaemia in type 2 diabetes mellitus. FRONTIERS IN IMMUNOLOGY. 1-19. 2019
- Cryobanking the genetic diversity in the critically endangered Iberian lynx (Lynx pardinus)from skin biopsies. Investigating the cryopreservation and culture ability of highly valuable explants and cells. CRYOBIOLOGY. 145-151. 2019
- Derivation of HVR1, HVR2 and HVR3 human embryonic stem cell lines from IVF embryos after preimplantation genetic diagnosis (PGD) for monogenic disorder. STEM CELL RESEARCH. 635-639. 2019
- Development of a cell-based medicinal product: regulatory structures in the European Union. BRITISH MEDICAL BULLETIN. 85-105. 2019
- Differentiation of Mouse Embryonic Stem Cells Towards Functional Pancreatic Beta-Cell Surrogates through Epigenetic Regulation of Pdx1 by Nitric Oxide. CELL TRANSPLANTATION. 1879-1892. 2019
- Directed Pancreatic Acinar Differentiation of Mouse Embryonic Stem Cells via Embryonic Signalling Molecules and Exocrine Transcription Factors. PLOS ONE. 54243-54250. 2019
- Dissecting the Brain/Islet Axis in Metabesity. GENES. 1-20. 2019
- Dual Trade of Bcl-2 and Bcl-xL in Islet Physiology: Balancing Life and Death With Metabolism Secretion Coupling. DIABETES. 18-21. 2019
- EGF-induced adipose tissue mesothelial cells undergo functional vascular smooth muscle differentiation. CELL DEATH & DISEASE. 1-11. 2019
- Extra virgin olive oil diet intervention improves insulin resistance and islet performance in diet-induced diabetes in mice. SCIENTIFIC REPORTS. 11311-13121. 2019
- Functional Vascular Smooth Muscle-like Cells Derived from Adult Mouse Uterine Mesothelial Cells. PLOS ONE. 55181-55188. 2019
- GATA4 and GATA6 control mouse pancreas organogenesis. JOURNAL OF CLINICAL INVESTIGATION. 3504-3515. 2019
- GATA4 loss in the septum transversum mesenchyme promotes liver fibrosis.. HEPATOLOGY. 2358-2370. 2019
- GATA6 Controls Insulin Biosynthesis and Secretion in Adult ß-Cells. DIABETES. 448-460. 2019
- Gene-Diet Interactions in Type 2 Diabetes: The Chicken and Egg Debate. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-7. 2019
- Human mesenchymal stem cells prevent neurological complication of radiotherapy. FRONTIERS IN CELLULAR NEUROSCIENCE. 2-11. 2019
- Impact of exposure to low concentrations of nitric oxide on protein profile in murine and human pancreatic islet cells. ISLETS. 99599-5997. 2019
- Impact of transient down-regulation of DREAM in human embryonic stem cell pluripotency: The role of DREAM in the maintenance of hESCs. STEM CELL RESEARCH. 568-578. 2019
- Inadequate control of thyroid hormones sensitizes to hepatocarcinogenesis and unhealthy aging. AGING-US. 7746-7779. 2019
- Islet cell development . ADVANCES IN EXPERIMENTAL MEDICINE AND BIOLOGY. 59-75. 2019
- L-Type Ca(2+) Channels and SK Channels in Mouse Embryonic Stem Cells and Their Contribution to Cell Proliferation. JOURNAL OF MEMBRANE BIOLOGY. 671-682. 2019
- LRH-1 agonism favours an immune-islet dialogue which protects against diabetes mellitus.. NATURE COMMUNICATIONS. 1488-1492. 2019
- Low concentrations of nitric oxide delay the differentiation of embryonic stem cells and promote their survival. CELL DEATH & DISEASE. 1-11. 2019
- Natural Killer Cells Improve Hematopoietic Stem Cell Engraftment by Increasing Stem Cell Clonogenicity In Vitro and in a Humanized Mouse Model. PLOS ONE. 1386-8623. 2019
- Nitric Oxide Prevents Mouse Embryonic Stem Cell Differentiation Through Regulation of Gene Expression, Cell Signaling, and Control of Cell Proliferation. JOURNAL OF CELLULAR BIOCHEMISTRY. 2078-2088. 2019
- Nitric oxide repression of Nanog promotes mouse embryonic stem cell differentiation . CELL DEATH AND DIFFERENTIATION. 1025-1033. 2019
- PAX4 Defines an Expandable ß-Cell Subpopulation in the Adult Pancreatic Islet. SCIENTIFIC REPORTS. 15672-15679. 2019
- PDGF Restores the Defective Phenotype of Adipose-Derived Mesenchymal Stromal Cells from Diabetic Patients. MOLECULAR THERAPY. 30382-30384. 2019
- Pancreatic differentiation of Pdx1-GFP reporter mouse induced pluripotent stem cells. DIFFERENTIATION. 30015-30019. 2019
- Regulation of pancreatic ß-cell survival by nitric oxide: Clinical relevance. ISLETS. 108-118. 2019
- Resveratrol Ameliorates the Maturation Process of ß-Cell-Like Cells Obtained from an Optimized Differentiation Protocol of Human Embryonic Stem Cells. PLOS ONE. 1199-9904. 2019
- Role of nitric oxide in the maintenance of pluripotency and regulation of the hypoxia response in stem cells. WORLD JOURNAL OF STEM CELLS. 605-617. 2019
- Single mechanosensitive and Ca2+-sensitive channel currents recorded from mouse and human embryonic stem cells. JOURNAL OF MEMBRANE BIOLOGY. 215-230. 2019
- Sirtuin 1 regulation of developmental genes during differentiation of stem cells. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 13736-13741. 2019
- Stability of the packaging system and storage conditions of human mesenchymal ítem cell for intraarterial clinical application in patient with critical limb ischaemia. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 459-468. 2019
- Standard Requirement of a Microbiological Quality Control Program for the Manufacture of Human Mesenchymal Stem Cells for Clinical Use. STEM CELLS AND DEVELOPMENT. 1074-1083. 2019
- The immune boundaries for stem cell based therapies: problems and prospective solutions. . JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 1464-1475. 2019
- The type 2 diabetes-associated HMG20A gene is mandatory for islet beta cell functional maturity. CELL DEATH & DISEASE. 279-285. 2019
- Transcriptional control of mammalian pancreas organogenesis. CELLULAR AND MOLECULAR LIFE SCIENCES. 2383-2014. 2019
- Transient Downregulation of Nanog and Oct4 Induced by DETA/NO Exposure in Mouse Embryonic Stem Cells Leads to Mesodermal/Endodermal Lineage Differentiation. STEM CELLS INTERNATIONAL. 379678-379680. 2019
- Umbilical cord blood plasma contains soluble NKG2D ligands that mediate loss of natural killer cell function and cytotoxicity. EUROPEAN JOURNAL OF IMMUNOLOGY. 2324-2334. 2019
- Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY. 117-123. 2019
- Using stem cells to produce insulin. EXPERT OPINION ON BIOLOGICAL THERAPY. 1469-1489. 2019
- Zebularine regulates early stages of mESC differentiation: effect on cardiac commitment. CELL DEATH & DISEASE. 570-571. 2019
- miR-7 Modulates hESC Differentiation into Insulin-Producing Beta-like Cells and Contributes to Cell Maturation.. MOLECULAR THERAPY-NUCLEIC ACIDS. 463-477. 2019
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chapter
- Mesenchymal Stromal Cell-Based Therapies as Promising Treatments for Muscle Regeneration After Snakebite Envenoming. Venoms and Toxins: At the Crossroads of Basic, Applied and Clinical Immunology. 86-103. 2021
- Generation of pancreatic islets from stemcells. Principles of Tissue Engineering 5th editionEditores Lanza , Langer, Vacanti, Attala. 1-8. 2020
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congress communication
- BISPHENOL-A MODULATES ION CHANNEL EXPRESSION AND FUNCTION VIA ESTROGEN RECEPTOR ¿ IN MOUSE PANCREATIC BETA CELLS 2019
- Bisphenol-A modulates ion channel expression and activity in mouse pancreatic beta cell via oestrogen receptor beta (ERbeta) 2019
- Differential effects of chronic exposure to bisphenol A on ion channel activity and expression in mouse pancreatic ß-cells 2019