Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

SOGORB SÁNCHEZ, MIGUEL ANGEL

Person (Active)

Positions

Catedrático/a de Universidad, Biología Aplicada 2018 -
PDI INVESTIGADOR, Instituto de Bioingeniería 2004 -
MIEMBRO, Toxicología y Salud Medioambiental 2007 -
Profesor Titular Universidad, Biología Aplicada 2009 - 2018
Profesor/a Titular Universidad, Biología Aplicada 2009 - 2018
Profesor/a Contratado/a Doctor/a, Biología Aplicada 2006 - 2009
Profesor/a Colaborador/a, Biología Aplicada 2005 - 2006

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supported publications or other works

selected publications

academic article
- Inhibition with simultaneous spontaneous reactivation and aging of acetylcholinesterase by organophosphorus compounds: Demeton-S-methyl as a model. CHEMICO-BIOLOGICAL INTERACTIONS. 1-10. 2023
- Investigation of the Effects of Metallic Nanoparticles on Fertility Outcomes and Endocrine Modification of the Hypothalamic-Pituitary-Gonadal Axis. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 11687-11702. 2023
- Reference Values on Children¿s Hair for 28 Elements (Heavy Metals and Essential Elements) Based on a Pilot Study in a Representative Non-Contaminated Local Area. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 8127-8145. 2023
- A Transcriptomic Analysis of T98G Human Glioblastoma Cells after Exposure to Cadmium-Selenium Quantum Dots Mainly Reveals Alterations in Neuroinflammation Processes and Hypothalamus Regulation. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2267-2284. 2022
- Case study: risk associated to wearing silver or graphene nanoparticlecoated facemasks for protection against COVID-19. ARCHIVES OF TOXICOLOGY. 105-109. 2022
- Human-Based New Approach Methodologies in Developmental Toxicity Testing: A Step Ahead from the State of the Art with a Feto-Placental Organ-on-Chip Platform. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH. 15828-15859. 2022
- Case study: risk associated to wearing silver or graphene nanoparticle-coated facemasks for protection against COVID-19. ARCHIVES OF TOXICOLOGY. 2021
- DAEH N-terminal sequence of avian serum albumins as catalytic center of Cu (II)-dependent organophosphorus hydrolyzing A-esterase activity. CHEMICO-BIOLOGICAL INTERACTIONS. 109524-109528. 2021
- Interactions of human acetylcholinesterase with phenyl valerate and acetylthiocholine: Thiocholine as an enhancer of phenyl valerate esterase activity. CHEMICO-BIOLOGICAL INTERACTIONS. 1-12. 2021
- Titanium Dioxide, but Not Zinc Oxide, Nanoparticles Cause Severe Transcriptomic Alterations in T98G Human Glioblastoma Cells. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 2084-2110. 2021
- Effects of silver nanoparticles on T98G human glioblastoma cells. TOXICOLOGY AND APPLIED PHARMACOLOGY. 115178-115194. 2020
- Case study: Is bisphenol S safer than bisphenol A in thermal papers?. ARCHIVES OF TOXICOLOGY. 2019
- Albumin, the responsible protein of the Cu(2+)-dependent hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate (HDCP) by chicken serum "antagonistic stereoselectivity". FOOD AND CHEMICAL TOXICOLOGY. 523-527. 2018
- Cholinesterase and phenyl valerate-esterase activities sensitive to organophosphorus compounds in membranes of chicken brain. TOXICOLOGY. 73-82. 2018
- Hydrolyzing activities of phenyl valerate sensitive to organophosphorus compounds paraoxon and mipafox in human neuroblastoma SH-SY5Y cells. TOXICOLOGY. 123-128. 2018
- Copper activation of organophosporus compounds detoxication by chicken serum. FOOD AND CHEMICAL TOXICOLOGY. 417-423. 2017
- Acetylcholine-hydrolyzing activities in soluble brain fraction: Characterization with reversible and irreversible inhibitors. CHEMICO-BIOLOGICAL INTERACTIONS. 374-381. 2016
- Edtorial. Special Issue. CHEMICO-BIOLOGICAL INTERACTIONS. 49-50. 2016
- Effects of mipafox, paraoxon, chlorpyrifos and its metabolite chlorpyrifos-oxon, on the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells. CHEMICO-BIOLOGICAL INTERACTIONS. 368-373. 2016
- Roles of NTE protein and encoding gene in development and neurodevelopmental toxicity. CHEMICO-BIOLOGICAL INTERACTIONS. 352-357. 2016
- Expression of biomarker genes of differentiation in D3 mouse embryonic stem cells after exposure to different embryotoxicant and non-embryotoxicant model chemicals. DATA IN BRIEF. 354-365. 2015
- RNA transcripts for the quantification of differentiation allow marked improvements in the performance of embryonic stem cell test (EST). TOXICOLOGY LETTERS. 60-69. 2015
- An integrated approach for detecting embryotoxicity and developmental toxicity of environmental contaminants using in vitro alternative methods.. TOXICOLOGY LETTERS. 356-367. 2014
- Cholinesterase assay by an efficient time end-point method. METHODSX. 258-263. 2014
- Genomic and phenotypic alterations of the neuronal-like cells derived from human embryonal carcinoma stem cells (NT2) caused by exposure to organophosphorus compounds paraoxon and mipafox.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 905-926. 2014
- Interaction between substrates suggests a relationship between organophosphorus-sensitive phenylvalerate-and acetylcholine-hydrolyzing activities in chicken brain. TOXICOLOGY LETTERS. 132-138. 2014
- Organophosphorus pesticide chlorpyrifos and its metabolites alter the expression of biomarker genes of differentiation in D3 mouse embryonic stem cells in a comparable way to other model neurodevelopmental toxicants. CHEMICAL RESEARCH IN TOXICOLOGY. 1487-1495. 2014
- Silencing of PNPLA6, the Neuropathy Target Esterase (NTE) codifying gene, alters neurodifferentiation of human embryonal carcinoma stem cells (NT2). NEUROSCIENCE. 54-67. 2014
- Cytotoxic effect against 3T3 fibroblasts cells of saffron floral bio-residues extracts. FOOD CHEMISTRY. 55-59. 2013
- Functional pathways altered after silencing Pnpla6 (the codifying gene of Neuropathy Target Esterase) in mouse embryonic stem cells under differentiation. IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-ANIMAL. 2013
- The effect of CO2 concentration in neuroectoderm commitment of mouse embryonic stem cells. JOURNAL OF HISTOTECHNOLOGY. 11-16. 2013
- Cell differentiation markers as endpoints for in vitro developmental toxicity assays. TOXICOLOGY LETTERS. 10-11. 2012
- Characterization and Evolution of Exposure to Volatile Organic Compounds in the Spanish Shoemaking Industry over a 5-Year Period. JOURNAL OF OCCUPATIONAL AND ENVIRONMENTAL HYGIENE. 653-662. 2012
- Chlorpyrifos and its metabolites alter gene expression at non-cytotoxic concentrations in D3 mouse embryonic stem cells under in vitro differentiation. Considerations for embryotoxic risk assessment.. TOXICOLOGY LETTERS. 2012
- Interactions of neuropathy inducers and potentiators/promoters with soluble esterases. CHEMICO-BIOLOGICAL INTERACTIONS. 2012
- Chlorpyrifos and its metabolite, chlorpyrifos-oxon, modify the genic expression of mouse embryonic stem cells after 12 h of exposure. TOXICOLOGY LETTERS. 157-157. 2011
- Shortening and improving the embryonic stem cell test through the use of gene biomarkers of differentiation. JOURNAL OF TOXICOLOGY. 1-8. 2011
- 5-fluorouracil on ¿-fetoprotein gene expression during the in vitro mouse embryonic stem cell differentiation. INTERNATIONAL JOURNAL OF TOXICOLOGY. 297-304. 2010
- An alternative in vitro method for detecting neuropathic compounds based on acetylcholinesterase inhibition and on inhibition and aging of Neuropathy Target Esterase (NTE). TOXICOLOGY IN VITRO. 942-952. 2010
- Expression of Neuropathy Target Esterase (NTE) in mouse embryonic stem cells during differentiation. ARCHIVES OF TOXICOLOGY. 481-491. 2010
- Role of albumin in the detoxication of organophosphorus and carbamate pesticides. TOXICOLOGY LETTERS. 31-32. 2010
- Serum albumins and detoxication of anti-cholinesterase agents. CHEMICO-BIOLOGICAL INTERACTIONS. 325-339. 2010
- Caracterización parcial de la esterasa diana de neuropatía en células madre embrionarias de ratón. REVISTA DE TOXICOLOGIA. 33-33. 2009
- Improved analytical method for monitoring exposure to volatile compounds for occupational risk prevention. TOXICOLOGY LETTERS. 261-262. 2009
- Mouse embryonic stem cells for testing the role of neuropathy target esterase in embryogenesis. ALTEX-ALTERNATIVEN ZU TIEREXPERIMENTEN. 326-326. 2009
- Neuropathy Target Esterase in mouse embryonic stem cells. TOXICOLOGY LETTERS. 565-565. 2009
- Serum albumin, and not lipoprotein paraoxonase, is the responsible of the paraoxon detoxication at in vivo toxicologically relevant conditions. TOXICOLOGY LETTERS. 111-111. 2009
- Human serum albumin hydrolyzes the organophosphorus insecticides paraoxon, diazoxon, chlorpyrifos-oxon and O-hexyl O-2,5-dichlorophenyl phosphoramidate. TOXICOLOGY LETTERS. 29-29. 2008
- Serum albumin is as efficient as paraxonase in the detoxication of paraoxon at toxicological relevant concentrations. CHEMICAL RESEARCH IN TOXICOLOGY. 1524-1529. 2008
- A simple and rapid HPLC-MS method for the simultaneous determination of epinephrine, norepinephrine, dopamine and 5-hydroxytryptamine: application to the secretion of bovine chromaffin cell cultures.. JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND L. 88-94. 2007
- Albúmina de suero humano hidroliza paraoxon ¿in vitro¿. REVISTA DE TOXICOLOGIA. 131-131. 2007
- Albúmina es la proteína responsable de la destoxicación de carbaryl en suero in vivo. REVISTA DE TOXICOLOGIA. 131-131. 2007
- An in vitro approach for demonstrating the critical role of serum albumin in the detoxication of the carbamate carbaryl at in vivo toxicologically relevant concetrations. ARCHIVES OF TOXICOLOGY. 113-119. 2007
- Characterization of the Paraoxonase-like Activity Associated to Human Serum Albumin. TOXICOLOGY LETTERS. 237-237. 2007
- Comparative hydrolysis of O-hexyl O-2,5-dichlorophenyl phosphoramidate and paraoxon in different tissues of vertebrates. ARCHIVES OF TOXICOLOGY. 689-695. 2007
- Inhibición por mipafox de la actividad fenilvalerato esterasa en fracción particulada de medula adrenal bovina durante el tiempo de reacción enzima sustrato. REVISTA DE TOXICOLOGIA. 131-131. 2007
- Plasma phenylacetate and 1-naphthyl acetate hydrolyzing activities of wild birds as possible non-invasive biomarkers of exposure to organophosphorus and carbamate insecticides. TOXICOLOGY LETTERS. 278-285. 2007
- Recovery of neuropathy target esterase activity after inhibition with mipafox and O-hexyl O-2,5-dichlorophenyl phosphoramidate in bovine chromaffin cell cultures. CHEMICO-BIOLOGICAL INTERACTIONS. 99-105. 2007
- Stereospecific hydrolysis of a phosphoramidate as a model to understand the role of biotransformation in the neurotoxicity of chiral organophosphorus compounds. TOXICOLOGY LETTERS. 157-164. 2007
- Comparison of chromaffin cells from several animal sources for their use as an in vitro model to study the mechanism of organophosphorus toxicity. TOXICOLOGY LETTERS. 221-229. 2006
- Preliminar characterization of carboxylesterase activities found in plasma of wild birds. TOXICOLOGY LETTERS. 157-157. 2006
- Role of albumin in the detoxication of the carbamate carbaryl. TOXICOLOGY LETTERS. 65-65. 2006
- Análisis de la citotoxicidad de compuestos organofosforados sobre cultivos primarios de células cromafines bovinas.. REVISTA DE TOXICOLOGIA. 134-134. 2005
- Caracterización parcial de actividades carboxilesterasa de plasma de aves silvestres. REVISTA DE TOXICOLOGIA. 134-134. 2005
- Design of a chromatografic method for studying the effect of xenobiotics on the secretion of neurotransmitters. TOXICOLOGY LETTERS. 216-216. 2005
- La docencia de la toxicología en el Espacio Europeo de Educación Superior. una aproximación desde la asignatura de Biotoxinas. REVISTA DE TOXICOLOGIA. 44-48. 2005
- Bovine chromaffin cell cultures as model to study organophosphorus neurotoxicity. TOXICOLOGY LETTERS. 163-170. 2004
- Future applications of phosphotriesterases in the prophylaxis and treatment of organophosphorus insecticide and nerve agent poisonings . TOXICOLOGY LETTERS. 219-233. 2004
- Hydrolysis of carbaryl by human serum albumin. ARCHIVES OF TOXICOLOGY. 629-634. 2004
- Mipafox treatment increases the 5-HT secretion in bovine chromaffin cells cultures. TOXICOLOGY AND APPLIED PHARMACOLOGY. 293-294. 2004
- Nuevas perspectivas en los tratamientos de intoxicaciones por insecticidas organofosforados y agentes nerviosos de guerra.. REVISTA DE NEUROLOGIA. 739-747. 2004
- Cinética de inhibición por mipafox y actividad NTE en cultivos primarios de células cromafines. REVISTA DE TOXICOLOGIA. 131-131. 2003
- Distribution of serum paraoxon hydrolysing activity in large population using routine automized method in clinical laboratory. JOURNAL OF ANALYTICAL TOXICOLOGY. 290-293. 2003
- Estudio de carboxilesterasas en médula adrenal y cultivo primario de células cromafines de animales de abasto. REVISTA DE TOXICOLOGIA. 132-132. 2003
- Hidr��lisis del carbamato carbaryl por albúmina de suero de conejo. REVISTA DE TOXICOLOGIA. 113-113. 2003
- Neuropathy target esterase activity reactivation in chromaffin cell cultures treated with mipafox. TOXICOLOGY LETTERS. 49-49. 2003
- Papel de esterasas en la destoxicación de insecticidas organofosforados, carbamatos y piretroides. REVISTA DE TOXICOLOGIA. 85-86. 2003
- Enzymes involved in the detoxification of organophosphorus, carbamate and pyrethroid insecticides through hydrolysis. TOXICOLOGY LETTERS. 215-228. 2002
- Importancia de la hidrólisis estereoespecífica en la evaluación de riesgos de insecticidas fosforamidatos. REVISTA DE TOXICOLOGIA. 61-68. 2002
- Rabbit serum albumin hydrolyzes the carbamate carbaryl.. CHEMICAL RESEARCH IN TOXICOLOGY. 520-526. 2002
- Carboxilesterasas de Daphnia Magna como biomarcador de exposición a insecticidas organofosforados.. REVISTA DE TOXICOLOGIA. 181-181. 2001
- Enhancement, Relaxation, and Reversal of the Stereoselectivity for Phosphotriesterase by Rational Evolution of Active Site Residues. BIOCHEMISTRY. 1332-1339. 2001
- Fosfotriesterasas en la evaluación de riesgos de insecticidas organofosforados. REVISTA DE TOXICOLOGIA. 181-182. 2001
- Inhibición de actividad carboxilesterasa por mipafox en fracciones soluble y particulada de médula adrenal bovina.. REVISTA DE TOXICOLOGIA. 182-182. 2001
- Stereoselective Detoxification of Chiral Sarin and Soman Analogs by Phosphotriesterase. BIOORGANIC & MEDICINAL CHEMISTRY. 2083-2091. 2001
- Structural Determinants of the Substrate and Stereochemical Specificity of Phosphotriesterase. BIOCHEMISTRY. 1325-1331. 2001
- Hydrolisis of hexyl dichlorophenylphosphoramidate in hens, rat and rabbit. Neurotoxicology. 636-636. 2000
- Rationally Engineered Mutants of Phosphotriesterase for Preparative Scale Isolation of Chiral Organophosphates. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY. 10206-10207. 2000
- Determining reactivity and stereospecificity of phosphotriesterase from Pseudomonas diminuta by site-specific mutagenesis. FASEB J. 1999
- Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity. CHEMICO-BIOLOGICAL INTERACTIONS. 257-262. 1999
- EDTA-Resistant and Sensitive Phosphotriesterase Activities Associated with Albumin and Lipoproteins in Rabbit Serum. DRUG METABOLISM AND DISPOSITION. 53-59. 1999
- Hidrólisis estereoespecífica del O-hexil O-2,5-diclorofenil fosforamidato (HDCP) en gallina,rata y conejo. REVISTA DE TOXICOLOGIA. 150-151. 1999
- Peripheral nerve soluble esterases are spontaneously reactivated after inhibition by some OP compounds: Implications for a new definition of Neuropathy Target Esterase. CHEMICO-BIOLOGICAL INTERACTIONS. 541-550. 1999
- Peripheral nerve soluble esterases are spontaneously reactivated after inhibition by some op compounds: implications for a new definition of NTE. CHEMICO-BIOLOGICAL INTERACTIONS. 541-550. 1999
- Stereospecific hydrolisis of a phosphoramidate related to methamidophos in hen, rat and rabbit. TOXICOLOGY LETTERS. 59-59. 1999
- The concentration of tissue is an important factor in stereospecific enzymatic activity in ¿in vitro¿ assays. TOXICOLOGY IN VITRO. 689-692. 1999
- The role of phosphotriesterases in the detoxication of organophosphorus compounds. CRITICAL REVIEWS IN TOXICOLOGY. 21-57. 1999
book
- casos prácticos de evaluación de riesgos toxicologicos y ecotoxicologicos. EDITORIAL ELECTRONICA DE LA UNIVERSIDAD MIGUEL HERNANDEZ DE ELCHE. 2018
- TÉCNICAS ANALÍTICAS DE CONTAMINANTES QUÍMICOS. Aplicaciones toxicológicas, medioambientales y alimentarias.. Díaz de Santos. 2004
- Técnicas Analíticas Ambientales. UNIVERSIDAD MIGUEL HERNÁNDEZ. 2003
chapter
- Carbon tetrachloride. Encyclopedia of Toxicology (Fourth Edition). 555-560. 2023
- Chloroform. Encyclopedia of Toxicology (Fourth Edition). 921-928. 2023
- Ethyl acetate. Encyclopedia of Toxicology (Fourth Edition). 435-441. 2023
- Lubricating oils. Encyclopedia of Toxicology (Fourth Edition). 1-977. 2023
- Merphos. Encyclopedia of Toxicology (Fourth Edition). 141-147. 2023
- Okadaic acid. Encyclopedia of Toxicology (Fourth Edition). 99-105. 2023
- Petroleum distillates. Encyclopedia of Toxicology (Fourth Edition). 429-436. 2023
- Pyrene. Encyclopedia of Toxicology (Fourth Edition). 1-11. 2023
- Alternative methods to animal experimentation for testing developmental toxicity. Reproductive and Developmental Toxicity (3rd edition). 107-125. 2022
- Reproductive toxicity: in vivo testingguidelines from OECD. Reproductive and Developmental Toxicity (3rd edition). 165-178. 2022
- Toxicokinetics and toxicodynamics of DFP. Handbook of Toxicology of Chemical Warfare Agents Third Edition. 921-944. 2020
- Biomarkers for Testing Toxicity and MonitoringExposure to Xenobiotics. Biomarkers in Toxicology. 1165-1174. 2019
- Tendencias en Toxicología Celular y Molecular. EXPERTO EN TOXICOLOGÍA. 1-43. 2018
- OECD Guidelines for In Vivo Testing of Reproductive Toxicity. Reproductive and Developmental Toxicity. 163-178. 2017
- Validated and Nonvalidated Mechanism-Based Methods for Testing Developmental Toxicity. Reproductive and Developmental Toxicity. 193-209. 2017
- Air Quality of Textile and Related Industries. Comprehensive Analytical Chemistry (Volume 73): The Quality of Air. 785-800. 2016
- Toxicokinetics and Toxicodinamics of DFP. Handbook of Chemical Warfare Agents, 2nd edition. 857-874. 2015
- Biomarkers in biomonitoring of xenobiotics. BIOMARKERS IN TOXICOLOGY. 965-973. 2014
- Lubricating Oils. Encyclopedia of Toxicology. 670-676. 2014
- Petroleum Distillates. Encyclopedia of Toxicology. 828-833. 2014
- Biomarkers in biomonitoring of xenobiotics. BIOMARKERS IN TOXICOLOGY. 965-973. 2013
- Embryonic Stem Cells in Toxicological Studies. Embryonic Stem Cells - Basic Biology to Bioengineering. 213-230. 2011
- Mechanism-based models in reproductive and developmental toxicology. In: Reproductive and Developmental Toxicology. Reproductive and Developmental Toxicology. 135-146. 2011
- OECD guidelines and validated methods for in vivo testing of reproductive toxicity. Reproductive and Developmental Toxicology. 123-133. 2011
- DETOXICATION OF ANTICHOLINESTERASEPESTICIDES. Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology. 121-133. 2010
congress communication
patent
- METODO Y COMPOSICIONES PARA LA IDENTIFICACIÓN DE COMPUESTOS EMBRIOTOXICOS
- MÉTODOS Y COMPOSICIONES PARA LA IDENTIFICACIÓN DE COMPUESTOS EMBRIOTÓXICOS

presentations

invited conference
- BASES DE LA RECOMENDACIÓN LÍMITE DE EXPOSICIÓN OCUPACIONAL AL FORMALDEHÍDO: ASPECTOS TOXICOLÓGICOS, Conferencia 2019
- Comité RAC para la Evaluación del Riesgo. ECHA., Conferencia 2019
- Comités de la Comisión Europea. Comité RAC para la Evaluación del Riesgo. ECHA, Conferencia 2018
- Evaluating developmental toxicity using efficient short tests based in molecular approaches during cell differentiation: the example of chlorpyrifos, Conferencia 2014
- Human and mouse gene expression pathways of neural embryonic cell differentiation in developmental toxicity, Conferencia 2014
- Cell differentiation markers as endpoints for in vitro developmental toxicity assays, Conferencia 2012
- Role of albumin in the detoxication of organophosphorus and carbamate pesticides, Conferencia 2010
- Papel de esterasas en la destoxicación de insecticidas organofosforados, carbamatos y piretroides, Conferencia 2003