Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

BERMEJO SANZ, MARIA DEL VAL

Person (Active)

Positions

Catedrático/a de Universidad, Ingeniería 2010 -
MIEMBRO, Optimización Biofarmacéutica y disolución biopredictiva 2009 -
Profesor Titular Universidad, Ingeniería 2008 - 2010
Profesor/a Titular Universidad, Ingeniería 2008 - 2010

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supported publications or other works

ACTUALIZACIÓN Y REVISIÓN DE NORMATIVAS EN FORMULACIÓN MAGISTRAL DE USO HUMANO Y VETERINARIO EN EUROPA TFG
APOYO AL ESTUDIO DE INVESTIGACIÓN DE LA ABSORCIÓN DE FÁRMACOS ESENCIALES DE LA OMS MEDIANTE ADMINISTRACIÓN INTESTINAL EN RATA WISTAR TFG
Apoyo al estudio de investigación de la absorción de ácido clavulánico mediante administración intestinal en rata Wistar TFG
CARACTERIZACIÓN BIOFARMACÉUTICA DE ZOLPIDEM, CLOPERASTINA Y PRAVASTATINA 2014
Desarrollo de medios de disolución biorrelevantes para fármacos con problemas de bioequivalencia TFG
Desarrollo y aplicaciones de hidrogeles para la administración y liberación modificada de fármacos 2017
ESTUDIO DESCRIPTIVO DE LA RESISTENCIA A ANTIBIÓTICOS Y POLÍTICAS PALIATIVAS TFG
ESTUDIO FARMACOECONÓMICO Y DE MERCADO DE LA ATENCIÓN FARMACÉUTICA EN OFICINA DE FARMACIA TFG
Estudio de la variabilidad de modelos in situ e in vitro 2010
Evaluación de la Biodisponibilidad oral de Isoflavonas: papel de la microbiota intestinal 2014
FARMACOCINÉTICA POBLACIONAL DE LITIO EN PACIENTES PSIQUIÁTRICOS 2017
IN VITRO METHODS OF BIOPHARMACEUTICAL EVALUATION IN THE BLOOD-BRAIN BARRIER 2022
INFLUENCIA DE LOS EXCIPIENTES EN LA BIODISPONIBILIDAD ORAL 2020
INNOVATIVE IN VITRO METHOD AND PERMEABILITY ESTIMATION PROCEDURE TO PREDICT DRUG TRANSPORT ACROSS THE BLOOD-BRAIN BARRIER 2014
Influencia de los excipientes en la biodisponibilidad oral 2019
LA MICROBIOTA Y SU INFLUENCIA SOBRE LA TERAPIA FARMACOLÓGICA. TFG
MEDICAMENTOS APROPIADOS PARA PEDIATRÍA. UTILIZACIÓN DE UN SISTEMA DE CLASIFICACIÓN BIOFARMACÉUTICA PEDIÁTRICO PROVISIONAL COMO HERRAMIENTA DE DECISIÓN 2021
MODELADO FARMACOCINÉTICO POBLACIONAL DE LA ABSORCIÓN IN SITU DEL ÁCIDO CLAVULÁNICO TFM
MODELOS IN VITRO DE LA BARRERA HEMATOENCEFALICA: IMPLICACION DEL TRANSPORTE DEL CORTISOL EN LA DEPRESION Y SU MODULACION POR ACIDOS GRASOS 2010
Medicamentos apropiados para pediatría. Utilización de un Sistema de Clasificación Biofarmacéutica pediátrico provisional como herramienta de decisión. 2020
NANOPARTÍCULAS EN EL SISTEMA NERVIOSO CENTRAL TFG
OPTIMIZACIÓN BIOFARMACÉUTICA EN ENFERMEDADES TROPICALES DESATENDIDAS. TFG
Validacion de un modelo "in situ"de prediccion de absorciÃ³n en colon. Aplicacion al desarrollo de formas de liberacion controlada 2017

selected publications

academic article
- In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug. PHARMACEUTICS. 1-14. 2024
- Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole. PHARMACEUTICS. 1-13. 2024
- Access to the CNS: Strategies to overcome the BBB. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2023
- Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood-Brain Barrier in Patients with Glioblastoma.. PHARMACEUTICS. 1430-1442. 2023
- Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets. AAPS JOURNAL. 45-57. 2023
- Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain. NANOMEDICINE. 1799-1813. 2023
- An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies. NANOMATERIALS. 1-36. 2022
- Challenges Associated with the Surface pH of Drug Particles: Integration into Mechanistic Oral Absorption Modeling. AAPS JOURNAL. 17-28. 2022
- Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients. PHARMACEUTICS. 2565-2577. 2022
- Exploring the Predictive Power of the In Situ Perfusion Technique towards Drug Absorption: Theory, Practice, and Applications. MOLECULAR PHARMACEUTICS. 749-762. 2022
- Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development. PHARMACEUTICS. 182-197. 2022
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 121415-121426. 2022
- Radiolabeled Trastuzumab Solid Lipid Nanoparticles for Breast Cancer Cell: in Vitro and in Vivo Studies. ACS OMEGA. 30015-30027. 2022
- Ventajas del uso de la iontoforesis para la administración transdérmica de analgésicos. ACTUALIDAD EN FARMACOLOGIA Y TERAPEUTICA. 114-131. 2022
- A Differential Equation Based Modelling Approach to Predict Supersaturation and In Vivo Absorption from In Vitro Dissolution-Absorption System (idas2) Data. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 1-12. 2021
- An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products. PHARMACEUTICS. 507-519. 2021
- Dissolution challenges associated with the surface pH of drug particles: integration into mechanistic oral absorption modeling. AAPS JOURNAL. 1-11. 2021
- Eremantholide C from aerial parts of Lychnophora trichocarpha, as drug candidate: fraction absorbed prediction in humans and BCS permeability class determination. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES. 195-203. 2021
- Formulaciones para la cicatrización de heridas, presente y futuro.. REVISTA ESPAÑOLA DE CIENCIAS FARMACEUTICAS. 1-12. 2021
- In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 120-126. 2021
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2021
- One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products. PHARMACEUTICS. 690-709. 2021
- Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat.. PHARMACEUTICS. 1402. 2021
- pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis.. PHARMACEUTICS. 94. 2021
- Application of the Gastrointestinal Simulator (GIS) coupled with in silico modeling to measure the impact of Coca-Cola® on the luminal and systemic behavior of loratadine (BCS class 2b). PHARMACEUTICS. 566-590. 2020
- Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019. PHARMACEUTICS. 316-330. 2020
- Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs. PHARMACEUTICS. 988-1002. 2020
- Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool. PHARMACEUTICS. 633. 2020
- Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats. MOLECULAR PHARMACEUTICS. 2310-2318. 2020
- Effect of excipients on oral absorption process according to the different gastrointestinal segments. EXPERT OPINION ON DRUG DELIVERY. 1-20. 2020
- Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 168-176. 2020
- In vivo predictive dissolution (IPD) for Carbamazepine formulations: Additional evidence regarding the universal biopredictive dissolution medium. . PHARMACEUTICS. 558-579. 2020
- Mechanistic Physiologically-Based Biopharmaceutics Modeling (PBBM) Approach to Assess the In Vivo Performance of an Orally Administered Drug Product: From IVIVC to IVIVP. PHARMACEUTICS. 74-102. 2020
- Modelización y tratamiento matemático de la epidemia COVID-19 en España hasta junio de 2020. PHARMATECH. 80-88. 2020
- New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 6502. 2020
- Oral controlled release dosage forms: dissolution versus diffusion. EXPERT OPINION ON DRUG DELIVERY. 791-803. 2020
- Two-step in vitro-in vivo correlations: Deconvolution and convolution methods, which one gives the best predictability? Comparison with one-step approach. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 185-197. 2020
- Unraveling the behavior of oral drug products inside the human gastrointestinal tract using the aspiration technique: history, methodology and applications. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-16. 2020
- WHO Biowaiver Study Project for COVID-19 Outbreak: Dexamethasone Solubility Results for Biopharmaceutical Classification System. WHO DRUG INFORMATION. 466-471. 2020
- "Development of Fixed Dose Combination Products" Workshop Report: Considerations of Gastrointestinal Physiology and Overall Development Strategy.. AAPS JOURNAL. 75-91. 2019
- Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System. PHARMACEUTICS. 567-583. 2019
- Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 174-183. 2019
- Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses. PHARMACEUTICS. 122-140. 2019
- Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 154-161. 2019
- In Vivo Predictive Dissolution and Simulation Workshop Report: Facilitating the Development of Oral Drug Formulation and the Prediction of Oral Bioperformance. AAPS JOURNAL. 100-108. 2019
- Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1606-1616. 2019
- Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products.. PHARMACEUTICS. 663-673. 2019
- Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 36-42. 2019
- Mechanisticanalysisandexperimentalverificationofbicarbonatecontrolledentericcoatdissolution:Potentialinvivoimplications. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 47-58. 2019
- Report from the "3rd International Symposium on BA/BE of Oral Drug Products: Biopharmaceutics meets Galenics". JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY. 0-10. 2019
- Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2231-2241. 2018
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.. PHARMACEUTICAL RESEARCH. 1-12. 2018
- Computer simulations for bioequivalence trials: Selection of analyte in BCS class II and IV drugs with first-pass metabolism, two metabolic pathways and intestinal efflux transporter. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 193-203. 2018
- Defining level A IVIVC dissolution specifications based on individual in vitro dissolution profiles of a controlled release formulation. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 200-207. 2018
- Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 148-157. 2018
- Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 258-269. 2018
- Formulation Predictive Dissolution (fPD) Testing to Advance Oral Drug Product Development: an Introduction to the US FDA Funded '21st Century BA/BE' Project. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 120-27. 2018
- Gastric Emptying and Intestinal Appearance of Nonabsorbable Drugs Phenol Red and Paromomycin in Human Subjects: A Multi-Compartment Stomach Approach. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 162-174. 2018
- Giardiasis: Characteristics, Pathogenesis and New Insights About Treatment. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 1287-1303. 2018
- In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC. MOLECULAR PHARMACEUTICS. 2307-2315. 2018
- Ionic hydrogel based on chitosan crosslinked with 6-Phosphogluconic Trisodium salt. BIOMACROMOLECULES. 1294-1304. 2018
- Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 1: Fasted State Conditions. MOLECULAR PHARMACEUTICS. 5454-5467. 2018
- Linking the Gastrointestinal Behavior of Ibuprofen with the Systemic Exposure between and within Humans-Part 2: Fed State.. MOLECULAR PHARMACEUTICS. 5468-5478. 2018
- Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs.. PHARMACEUTICS. 213-228. 2018
- Mass Transport Analysis of the Enhanced Buffer Capacity of the Bicarbonate¿CO2 Buffer in a Phase-Heterogenous System: Physiological and Pharmaceutical Significance. MOLECULAR PHARMACEUTICS. 5291-5301. 2018
- Measuring The Impact of Gastrointestinal Variables On The Systemic Outcome of Two Suspensions of Posaconazole by a PBPK Model. AAPS JOURNAL. 57-64. 2018
- Preclinical models for colonic absorption, application to controlled release formulation development.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 247-259. 2018
- Semi-mechanistic Pharmacokinetic/Pharmacodynamic model of three pegylated rHuEPO and ior®EPOCIM in New Zealand rabbits. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 123-132. 2018
- Summary of the In Vivo Predictive Dissolution (iPD) ¿Oral Drug Delivery (ODD) Conference. DISSOLUTION TECHNOLOGIES. 49-53. 2018
- Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 191-196. 2017
- Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers. PLOS ONE. 17206-17207. 2017
- Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue.. MOLECULAR PHARMACEUTICS. 2017
- IVIVC approach based on Carbamazepine Bioequivalence. PHARMAZIE. 449-455. 2017
- Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 135-141. 2017
- Low Buffer Capacity and Alternating Motility along the Human Gastrointestinal Tract: Implications for in Vivo Dissolution and Absorption of Ionizable Drugs.. MOLECULAR PHARMACEUTICS. 2017
- PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2017
- Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture.. MOLECULAR PHARMACEUTICS. 1264-1270. 2017
- Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles. AAPS JOURNAL. 1550-1561. 2016
- Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 334-340. 2016
- Enhancing Oral Absorption of ß-Lapachone: Progress Till Date.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-9. 2016
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 795-806. 2016
- Population pharmacokinetic model of lithium and drug compliance assessment. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1868-1876. 2016
- Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 201-208. 2016
- . In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model . JOURNAL OF PHARMACEUTICAL SCIENCES. 3136-3145. 2015
- Cyclometalated Iminophosphorane Gold(III) and Platinum(II). JOURNAL OF MEDICINAL CHEMISTRY. 5825-5841. 2015
- Drug gastrointestinal absorption in rat: strain and gender differences. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 198-203. 2015
- Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling. MOLECULAR DIVERSITY. 1-17. 2015
- In vitro¿in vivo correlations: general concepts, methodologies and regulatory applications. DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY. 1935-1947. 2015
- In-situ intestinal rat perfusions for human F-abs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 1-7. 2015
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-12. 2015
- Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I. MOLECULAR PHARMACEUTICS. 3167-3174. 2015
- Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18396-18411. 2015
- Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid. European journal of pharmaceutical sciences. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 86-94. 2015
- Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 57-63. 2015
- A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 366-373. 2014
- Modified Non-Sink Equation for Permeability Estimation in Cell Monolayers: Comparison with Standard Methods . MOLECULAR PHARMACEUTICS. 1403-1414. 2014
- Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors (2). BRITISH JOURNAL OF PHARMACOLOGY. 1-12. 2014
- Validation of phenol red versus gravimetric method for water reabsorption correction and study of gender differences in Doluisio's absorption technique. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 105-110. 2014
- Variability of Permeability Estimation from Different Protocols of Subculture and Transport Experiments in Cell Monolayers.. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS . 1-11. 2014
- Hydrogels: an interesting strategy for smart drug delivery.. THERAPEUTIC DELIVERY. 157-160. 2013
- Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier . MOLECULAR PHARMACEUTICS. 3822-3831. 2013
- Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 499-504. 2013
- Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract . XENOBIOTICA. 745-754. 2013
- Provisional classification and in silico study of biopharmaceutical system based on caco-2 cell permeability and dose number. MOLECULAR PHARMACEUTICS. 2445-2461. 2013
- Purely in-silico BCS classification: Science based quality standards for the world's drugs. MOLECULAR PHARMACEUTICS. 4378-4390. 2013
- Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecin Derivatives. ACS MEDICINAL CHEMISTRY LETTERS. 86-90. 2013
- The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability. MOLECULAR INFORMATICS. 459-479. 2013
- SPR in oral bioavailability: specificity or integrality?. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 534-550. 2012
- A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.. PHARMACEUTICAL STATISTICS. 1-37. 2011
- Assessment of fexofenadine hydrochloride permeability and dissolution with an anionic surfactant using Caco-2 cells.. PHARMAZIE. 747-753. 2011
- In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach. MOLECULAR INFORMATICS. 376-385. 2011
- In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-21. 2011
- Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 290-291. 2011
- A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies. PHARMACEUTICAL STATISTICS. 0-37. 2010
- An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2010
- Computer simulations for bioequivalence trials (3): drugs with first-pass metabolism and two metabolic pathways. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010
- Drug penetration across the blood¿brain barrier: an overview. THERAPEUTIC DELIVERY. 535-562. 2010
- Unique pharmacology of Kar-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 11-19. 2009
- Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Aciclovir . JOURNAL OF PHARMACEUTICAL SCIENCES. 5061-5073. 2008
- Computer simulations of bioequivalence trials: Selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Part II. Non-linear kinetics. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2008
- Computer simulations of bioequivalence trials: Selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Linear kinetics (I). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2008
- Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND. 1-19. 2008
- Unique pharmacology of KAR-2, a potential anti-cancer. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-12. 2008
- Bias in estimation of transporter kinetic parameters from overexpression systems: Interplay of transporter expression level and substrate affinity . JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 133-144. 2007
- In situ kinetics modelling of intestinal efflux in rats: functional characterization of segmental diferences and correlation with in vitro results. BIOPHARMACEUTICS & DRUG DISPOSITION. 229-239. 2007
- Pharmacokinetics in drug discovery.. JOURNAL OF PHARMACEUTICAL SCIENCES. 654-690. 2007
- Tecnologias para conocer la posibilidad de mejorar la biodisponibilidad oral. INDUSTRIA FARMACEUTICA. 58-64. 2007
- A provisional biopharmaceutical classification of the top 200 oral drug products in the Unitad States, Great Britain, Spain and Japan. MOLECULAR PHARMACEUTICS. 631-643. 2006
- A topological Sub-structual Approach for the Prediction of P-Glycoprotein susbtrates. JOURNAL OF PHARMACEUTICAL SCIENCES. 589-606. 2006
- Estudios de biosimulación. FARMAESPAÑA INDUSTRIAL SOLUCIONES DE SOFTWARE. 46-49. 2006
- Mathematical modelling of in situ and in vitro efflux of ciprofloxacin and grepafloxacin. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 33-41. 2006
- Kinetic modelling of passive transport and active efflux of a fluoquinolone across Caco-2 cells using a compartmental approach in NONMEM. XENOBIOTICA. 1067-1088. 2005
- Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. JOURNAL OF DRUG TARGETING. 199-212. 2005
- Prediction of intestinal Epithelial Transport of Drug in Caco-2 cell culture from molecular structure using in silico Approaches During Early Drug Discovery. INTERNET ELECTRONIC JOURNAL OF MOLECULAR DESIGN . 124-150. 2005
- A topological substructural approach for predicting human intestinal absorption of drugs. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 905-916. 2004
- In silico prediction of central nervous system activity of compounds. Identification of potential pharmacophores by the TOPS-MODE approach . BIOORGANIC & MEDICINAL CHEMISTRY. 5833-5843. 2004
- PAMPA a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 429-441. 2004
- TOPS-MODE approach for the prediction of Blood Bran Barrier permeation. JOURNAL OF PHARMACEUTICAL SCIENCES. 1701-1717. 2004
- A topological-substructural molecular design (TOPS-MODE) approach to determining pharmacokinetics and pharmacological properties of 6-fluoroquinolones derivatives. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 197-206. 2003
- Kinetic modeling triamterene intestinal absorption and its inhibition by folic acid and methotrexate. JOURNAL OF DRUG TARGETING. 215-223. 2003
- Transintestinal secretion of ciprofloxacin, grapafloxacin and sparfloxacin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 241-246. 2003
chapter
- Importance and applications of cell-and tissue-based in vitro models for drug permeability screening in early stages of drug development. Concepts and models for drug permeability studies. 5-41. 2024
- In silico, in situ, in vitro, and in vivo predictive methods for modeling formulation performance.. From Current to Future Trends in Pharmaceutical Technology. 67-116. 2024
- In silico, in situ, in vitro and in vivo predictive methods for modelling formulation performance. From Current to Future Trends in Pharmaceutical Technology. 67-117. 2023
- In vitro ¿ in vivo correlation: General Concepts, Development and Advanced Approaches . CorrelaÇao in vitro in vivo no desenvolvimento de Medicamentos. 1-32. 2023
- Medicamentos genéricos ¿iguales a la marca de referencia?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 181-189. 2022
- Medicamentos vía oral: ¿con qué volumen de agua se deben administrar?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 247-256. 2022
- Nutracéuticos para cuidar la piel. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 115-128. 2022
- Seguridad en cosmética: cosmética natural e ingredientes controvertidos. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 129-140. 2022
- ¿Influyen los alimentos en el efecto de los medicamentos?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 257-270. 2022
- Differential absorption of curcuminoids between free and liposomed curcumin formularions. Curcumin. Clinical uses, health effects and potential complications. 99-111. 2016
- Absorción transdermica: Modelos in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 321-330. 2015
- Ajuste nolineal por mínimos cuadrados en Excel. Uso de herramienta Solver. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 539-567. 2015
- Cálculo depermeabilidad en rata: perfusión sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 499-504. 2015
- Cálculos de lapermeabilidad intestinal in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 482-489. 2015
- Cálculos denúmeros adimensionales. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 479-481. 2015
- Cálculos depermeabilidad en células de Franz. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 490-496. 2015
- Cálculos develocidad de disolución. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 505-538. 2015
- Cálculos en bioequivalencia. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 454-478. 2015
- Estudios de permeabilidad en humanos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 241-265. 2015
- Fundamentoscientíficos del BCS y de la Bioequivalencia in vitro: Aspectos teóricos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 66-83. 2015
- Importance and applications of cell and tissue-based in vitro models for drug permeability screening in early stages of drug development. In:Concepts and models for drug permeability studies ¿ Cell and tissue-based in vitro culture models.. Woodhead Publishing Series in Biomedicine. 1-15. 2015
- Investigación animal para el desarrollo de nuevos fármacos: reducir, refinar o reemplazar.. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 166-182. 2015
- Perfusion in situ sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 349-359. 2015
- Permeabilidad en cultivos celulares. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 266-299. 2015
- Prediccion de la fraccion oral absorbida. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 45-65. 2015
- Drug Absorption. Encyclopedia of Pharmaceutical Science and Technology. Fourth Edition. Six Volume Set. 1-17. 2013
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-26. 2012
- Biosimulation Studies. Molecular BiopharmaceuticsAspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation. 314-363. 2011
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-25. 2011
- Caco-2 cells for studying Intestinal absorption mechanisims: comparison and correlation with rat model. Caco-2 cells and their uses. 129-163. 2011
- Computer Simulations as a Tool for Optimizing Bioequivalence Trials. Pharmacokinetics. 1-18. 2011
- In vivo Methods for Oral Bioavailability Studies . Oral Bioavailability Studies, in Oral Bioavailability: Basic Principles, Advanced Concepts, and Applications . 493-503. 2011
- VIRTUAL BIOEQUIVALENCE TRIALS AS ATOOL FOR REGULATORY DECISIONS. Mathematical modeling, clustering algorithms and applications. 165-178. 2010
- ASSESSMENT OF STUDENT¿S OWN PERCEPTION OF LEARNING. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5392-5397. 2009
- ASSESSMENT OF THE KNOWLEDGE OF PHDS AND MASTERSTUDENTS DURING THIS TRAINING PERIOD. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5358-5363. 2009
- COMPUTER AIDED LEARNING IN BIOPHARMACY. International technology, education and development conference. 2923-2926. 2009
- EVALUATION OF THE PHD STUDENTS¿ ENGLISH LEVEL. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5364-5370. 2009
- KNOWLEDGE ABOUT EHEA OF THE UNIVERSITARY STUDENTS . ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5870-5873. 2009
- PROGRAM PROPOSAL FOR EARLY CONTACT OF PREGRADUATE STUDENTS WITH THE RESEARCH WORLD: OR HOW TO MAKE THE RIGHT DECISION AT THE RIGHT TIME. International technology, education and development conference. 4692-4696. 2009
- TEAMWORK IN LABORATORY PRACTICES. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5968-5971. 2009
- TOWARDS THE EUROPEAN SPACE FOR HIGHER EDUCATION:QUALITY OF THE TUTORIALS. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5387-5390. 2009
- HOW AND WHERE ARE DRUGS ABSORBED?. Biosimulation in Drug Development. 249-280. 2008
- Correlation between in vitro, in situ and in vivo models. Biosimulation in Drug Development. 89-109. 2007
congress communication

presentations

invited conference
- Ensayos de permeabilidad ICH para bioexención , Conferencia 2023
- Estudios de correlación in vitro-in vivo , Conferencia 2023
- Medios Biopredictivos , Conferencia 2023
- Sistema de Clasificación Biofarmacéutica (BCS): Generalidades y Potencialidades , Conferencia 2023
- ¿In vivo predictive dissolution IPD as tool for generic development¿, Conferencia 2022
- Predicción de la disolución in vivo como herramienta en el desarrollo de genéricos, Conferencia 2022
- Relevant physiological variables to design in vivo predictive dissolution methods, Conferencia 2022
- Relevant physiological variables to design in vivo predictive dissolution methods, Conferencia 2022
- In vivo predictive dissolution: relevant gastrointestinal factors and methodological approaches: , Conferencia 2022
- "In vivo predictive dissolution: gastrointestinal factors and methodological approaches¿, Conferencia 2021
- Methods of decovolution, Conferencia 2019
- IVIVC regulatory aspects, Conferencia 2018
- mass transport analysis, Conferencia 2018
- disolucion predictiva para IVIVC, Conferencia 2018
- In Vitro Dissolution for a Marketed and Generic FDC Drug Product: Bioequivalent or not? , Conferencia 2018
- in vivo predictive dissolution, Conferencia 2018
- Modelling gastrointestinal variables to predict plasma levels , Conferencia 2017
- Interpreting drug concentration profiles in plasma and relating them to in vitro (in vivo) dissolution measurements/in silico predictions, Conferencia 2017
- Biopredictive media and methods: In vivo Supersaturation, Conferencia 2017
- Aplicación de la modelización y simulación en las IVIVC , Conferencia 2015
- Bioequivalence Requirements in the European Union: critical discussion, Conferencia 2014
- USP dissolution and in vivo relevance, Conferencia 2014
- ¿Extensiones científicas del BCS. Medios biopredictivos como herramientas de desarrollo¿, Conferencia 2014
- Bioequivalencia In vitro e in vivo, Conferencia 2013
- Desarrollo y escalamiento de un lote para cumplir las exigencias de BE, Conferencia 2013
- Alfa Programme: RedBiofarma, Conferencia 2012
- Regulations of Medical devices in latinoamerica, Conferencia 2012
- intercambiabilidad: utilidad bioequivalencia in vitro, Conferencia 2012
- Computer simulation of bioequivalence trials, Conferencia 2012
- Clasificación de permeabilidad según el BCS, Conferencia 2011
- ¿In vitro Bioequivalence. Why, When and How?: Applications of the, Conferencia 2010
- Non Linear Pharmacokinetcis, Conferencia 2010
- Ethic aspects in pharmacokinetic research with children -, Conferencia 2010
- Biophysical Predictive Absorption Models and Applications, Conferencia 2010
- Gastrointestinal Physiological variables, Conferencia 2010
- Disolucion de fármacos poco solubles, Conferencia 2010
- La Red de Excelencia Biosim: Modelado y Simulación de procesos biológicos como herramienta de las tres R¿s. , Conferencia 2009
- Modelling and simulation in drug bioequivalence studies, Conferencia 2009
- Goals of the EU project Memtrans, Conferencia 2009
- Sistema de Clasificación Biofarmaceutico, Conferencia 2009
- Transport of pgp substrates at Caco-2, MDCK-WT and MDCK-PGP, Conferencia 2009
- Modelling and simulation in drug bioequivalence studies, Conferencia 2009
- Avances regulatorios de los estudios de equivalencia terapeutica, Conferencia 2009
- El proceso de liberación como factor limtativo de la absorción, Conferencia 2009
- Biophysical predictive absorption models and applications, Conferencia 2009
- Gastrointestinal physiological variables, Conferencia 2009
- Modelado del transporte de KAR2 en rata y en células Caco-2, Conferencia 2009
- Virtual Bioequivalence Trials: design and analyte selection in BCS drugs, Conferencia 2008
- ADME: EXPERIMENTS AND MODELLING, Conferencia 2008
- Biowaiver reports for EU Authorities , Conferencia 2008
- TBioavailability, Bioequivalence and BCS: an European Perspective , Conferencia 2008
- Gastrointestinal physiological variables , Conferencia 2008
- The BCS and the world drugs: a provisional classification , Conferencia 2008
- Modelado y comparación perfiles de disolución, Conferencia 2008
- BE in Vitro y clasificación provisional medicamentos OMS, Conferencia 2008
- Generalidades BCS-BDDCS, Conferencia 2008
- El papel de la farmacocinética y la farmacodinamia en el desarrollo de medicamento, Conferencia 2008
- Estándares de Bioequivalencia, Conferencia 2008
- Fisiología y anatomía GI y mecanismos absorción, Conferencia 2008
- Correlaciones in vitro in vivo, Conferencia 2008
- Fisiología GI. Permeabilidad y Mecanismos de absorción, Conferencia 2008
- Metabolismo de primer paso y Aclaramiento, Conferencia 2008
- Liberación inmediata, Liberación controlada y, Conferencia 2008
- Fisiología GI. Permeabilidad y Mecanismos de, Conferencia 2008
- Metabolismo de primer paso y Aclaramiento, Conferencia 2008
- Comparación de perfiles de disolución, Conferencia 2008
- Determinacion experimental de solubilidad y permeabilidad, Conferencia 2008
- Fundamentos cientificos del BCD y del BDDCS, Conferencia 2008
- Reducir refinar o reemplazar en el desarrollo de nuevos farmacos, Conferencia 2008
- Assessment of bioequivalence: parent drug or metabolite?, Conferencia 2008
- Experiencia com evaluadora de proyectos europeos, Conferencia 2008
- Compartmental modelling of data from permeability assays., Conferencia 2008
- Biophysical predictive absorption models & applications , Conferencia 2008
- Gastrointestinal variables, Conferencia 2008
- Bioequivalence assessment: parent drug or metabolite, Conferencia 2007
- Parent drug or metabolite in BE trials: Simulations using physiological-pharmacokinetic models with saturable and non-saturable hepatic clearance in single dose and steady state scenarios, Conferencia 2007
- Predicción de datos de absorción en estudios preclinicos de medicamentos, Conferencia 2007
- PREDICTING INTESTINAL ABSORPTION: MODELLING FROM IN VITRO TO IN VIVO, Conferencia 2005