Publications in VIVO

Co-author Network

Co-investigator Network

GONZALEZ ROS, JOSE MANUEL Person

Positions

Director, Relaciones Estructura-función en Proteínas de Membrana
MIEMBRO, Relaciones Estructura-función en Proteínas de Membrana
Catedrático de Universidad, Bioquímica y Biología Molecular

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selected publications

2002
- Characterization of the procaryotic KcsA channel reconstituted into giant liposomes: Effects of the inactivating ¿ball¿ peptide from the Shaker B K+ channel. 2002
2003
- Binding of the c-terminal sam domain of human p73 to lipid membranes 2003
- Intrinsic tyrosine fluorescence as a tool to study the interaction of the shaker b ¿ball¿ peptide with anionic membranes 2003
- Probing the channel-bound shaker b inactivating peptide by stereoisomeric substitution at a strategic residue 2003
- SAPOSIN-LIKE DOMAIN IS PRESENT IN MONOMERIC PLANT ASPARTIC PROTEASES 2003
- The C-terminal of the potassium channel KcsA modulates its structural and functional properties 2003
2004
- Efecto del nAcChr en la organización de biomembranas. 2004
- Estudio de desplegamiento del canal de potasio KcsA 2004
- Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel Kcsa 2004
- Phosphatidic acid modulates the properties of nicotinic acetylcholine receptors transplanted to Xenopus oocytes. 2004
- Reversible fording of the K+ channel KcsA 2004
2005
- Complete refolding of the potassium channel KcsA can be attained in the presence of lipids 2005
- In vitro unfolding and refolding of a tetrameric, á-helical membrane protein: the prokaryotic potassium channel KcsA 2005
- In vitro unfolding and refolding of a tetraméric, alpha helical membrane protein: The prokaryotic potassium channel KcsA 2005
- Nicotinic Acetylcholine Receptor properties are modulated by the surrounding lipid: An ¿in vivo¿ study 2005
- Phosphatidic acid modulates the properties of nicotinic acetylcholine receptors transplanted to Xenopus oocytes 2005
- Sodium destabilizes the structure of the potassium channel KcsA at concentrations causing channel blockade 2005
- Structural and functional changes induced in the nicotinic Acetylcholine Receptor by membrane phospholipids. 2005
2006
- Análisis estructural del proceso de bloqueo del canal KcsA por el péptido inactivante ShB 2006
- Caracterización biofísica y relevancia funcional de la agrupación (clustering) del canal de potasio KcsA 2006
- Clustering of the KcsA potassium channel 2006
- Estudio de la oligomerización del canal iónico procariótico KcsA 2006
- Modulación funcional del canal de potasio KcsA: formación de agrupaciones macromoleculares 2006
- ¿Cómo afectan los iones conductores y los bloqueantes a la estructura y la estabilidad del canal de potasio KcsA? 2006
2007
- EL CANAL DE POTASIO KCSA: UN MODELO PARA MUCHOS USOS 2007
- El canal de potasio KcsA: modelo para el estudio de la oligomerización y el plegamiento de proteínas de membrana 2007
- Estudio de la oligomerización del canal iónico procariótico KcsA 2007
- MOLECULAR DETERMINANTS OF KCSA CLUSTERING: THE ROLE OF CYTOPLASMATIC DOMAINS. 100-100. 2007
- Modulación funcional del canal de potasio KcsA: formación de agrupaciones macromoleculares 2007
- Molecular determinants of KcsA clustering: the role of cytoplasmatic domains. 2007
- Protein self-assembly and lipid binding in the folding of the potassium channel KcsA.. 163-163. 2007
- UNFOLDING AND REFOLDING OF A PREDOMINANTLY A-HELICAL, TETRAMERIC POTASSIUM CHANNEL PROTEIN. 93-93. 2007
2008
- Biología estructural de la inactivación rápida del canal procariota KCSA por peptidos de origen eucariota. 2008
2009
- Anionic lipids reveal molecular determinants involved in single and coupled gating in KcsA. 146-146. 2009
- Análisis de los mecanismos de inhibición de receptores nicotínicos por lidocaína mediante el empleo de sus análogos estructurales dietilamina y 2,6 dimetilanilina 2009
- Molecular determinants involved in clustering and coupled gaiting in KcsA 2009
- Role of ions and lipids on the conformation, stability and function of the potassium channel KcsA. 147-147. 2009
2010
- Immobilization and characterization of KcsA potassium channel into sol-gel glasses 2010
2011
- Current approaches on KcsA crystallization. Integrative research on ion channels. 2011
- Design and evaluation of new TRPV1 open channel blockers 2011
- Efecto de péptidos anti-clusters sobre el canal de potasio KcsA. 173-173. 2011
- Electroforesis blue-native para la cuantificación de la auto-asociación de KcsA. 103-103. 2011
- Inmovilización y caracterización de liposomas y proteoliposomas en matrices sol-gel: un estudio combinado de espectroscopía y microscopía de fluorescencia utilizando la sonda fluorescente Laurdan. 211-211. 2011
- Protein-protein and lipid-protein interactions in KcsA 2011
- Role of the conformation of selectivity filter in KcsA stability and function. 177-177. 2011
- Role of the conformation of selectivity filter in KcsA stability and function 2011
- Specific ions, specific lipids: sources of protein stability in an ion channel model 2011
2012
- A family of compounds with a common central scaffold renders modulators for TRPV1, TRPM8 and TRPA1 channels 2012
- Diethylamine blocks muscle-type nicotinic acetylcholine receptors by mimicking the action of charged lidocaine 2012
- Interaction Between the B-ball peptide and the KcsA channel as studied by NMR 2012
- Modulation of nicotinic acetylcholine receptors by lidocaine and structurally related molecules 2012
- Peptidomimetics design and function: peptides patterned after the TRIP domain of TRPV1 channel 2012
- Solution NMR structure of the ShB peptide in complex with KcsA. Frontiers in ion channel research, new findings and new challenges 2012
- TRPducins: a novel paradigm to modulate ion channel signalling 2012
2013
- Tryptophan mutants of KcsA channel as a tool to study ion and lipid-protein interaction 2013
2014
- Discovery of a new class of TRPV1 Open Channel Blockers (OCBs): Design, Synthesis, Evaluation and SAR data. 15th world congress of pain 2014
- The potassium channel KcsA: A model for developing useful tools in the understanding of potassium channels and design new potential drugs 2014
2015
- Discovery of a new class of TRPV1 open channel blockers (OCBS): design, synthesis, evaluation and structure activity relationship data 2015
- Homo-FRET studies of potassium channel KcsA: a closer look to the selectivity filter dynamics and regulation 2015
- Molecular mechanism for the lipid modulation of KcsA 2015
2016
- Molecular determinants involved in clustering and gating patterns in KcsA 2016
2017
- New insights into the inactivated state of the potassium channel KcsA 2017
- Optimization of neuronal differentiation for the study of MeCP2 protein expression 2017
- Optimization of neuronal differentiation for the study of MeCP2 protein expression 2017
2018
- COMPLEX INTERACTIONS OF TETRACAINE WITH MUSCLE-TYPE NICOTINIC RECEPTORS 2018
- Exploring potassium channel slectivity and inactivation through steady-state and time-resolved fluorescence spectroscopy 2018
- MULTIPLE BINDING SITES OF TETRACAINE IN THE MUSCLE-TYPE NICOTINIC ACETYLCHOLINE RECEPTOR 2018
- Modulation of the KcsA potassium channel by anionic phospholipids: roles of the non-annular arginines 2018
academic article
- Mechanisms underlying the strong inhibition of muscle-type nicotinic receptors by tetracaine. FRONTIERS IN MOLECULAR NEUROSCIENCE. 1-21. 2018
- Differential binding of monovalent cations to KcsA: Deciphering the mechanisms of potassium channel selectivity. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 779-788. 2017
- Selective exclusion and selective binding both contribute to ion selectivity in KcsA, a model potassium channel. JOURNAL OF BIOLOGICAL CHEMISTRY. 15552-15560. 2017
- Towards understanding the molecular basis of ion channel modulation by lipids: Mechanistic models and current paradigms. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1507-1516. 2017
- Muscle-Type Nicotinic Receptor Modulation by 2,6-Dimethylaniline, a Molecule Resembling the Hydrophobic Moiety of Lidocaine.. FRONTIERS IN MOLECULAR NEUROSCIENCE. 127-141. 2016
- _Muscle-Type Nicotinic Receptor Blockade by Diethylamine, the Hydrophilic Moiety of Lidocaine.. FRONTIERS IN MOLECULAR NEUROSCIENCE. 12-23. 2016
- Competing Lipid-Protein and Protein-Protein Interactions Determine Clustering and Gating Patterns in KcsA. JOURNAL OF BIOLOGICAL CHEMISTRY. 1-15. 2015
- Lipid modulation of ion channels through specific binding sites.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1560-1567. 2014
- Mutation of I696 and W697 in the Trp box of vanilloid receptor subtype I modulates allosteric channel activation. JOURNAL OF GENERAL PHYSIOLOGY. 361-375. 2014
- Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 193-200. 2013
- Highly functionalized 1,2¿diamino compounds through reductive amination of amino acid-derived ß¿keto esters. . PLOS ONE. 1-9. 2013
- Partitioning of Liquid-ordered / Liquid-disordered Membrane Microdomains Induced by the Fluidifying Effect of 2-Hydroxylated Fatty Acid Derivatives.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2553-2563. 2013
- Advances in modulating thermosensory TRP channels. EXPERT OPINION ON THERAPEUTIC TARGETS. 999-1017. 2012
- Contribution of ion binding affinity to ion selectivity and permeation in KcsA, a model potassium channel.. BIOCHEMISTRY. 3891-3900. 2012
- Detergent-labile, supramolecular assemblies of KcsA: relative abundance and interactions involved.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 0-11. 2012
- In silico-based direct evolution of peptides and peptidomimetics in drug discovery. CURRENT TOPICS IN PHARMACOLOGY. 35-55. 2012
- Mapping of Unfolding States of Integral Helical Membrane Proteins by GPS-NMR and Scattering Techniques. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 2290-2301. 2012
- Mutation of Ser-50 and Cys-66 in Snapin Modulates Protein Structure and Stability. BIOCHEMISTRY. 3470-3484. 2012
- New strategies to develop novel pain therapies: Addressing thermoreceptors from different points of view.. PHARMACEUTICALS. 16-48. 2012
- Ionic channels as targets for drug design: a review on computational methods. PHARMACEUTICS. 1-11. 2011
- Membrane-tethered peptides patterned after the TRP domain (TRPducins) potently and selectively inhibit TRPV1 channel activity. . FASEB J. 1628-1640. 2011
- Multiple inhibitory actions of lidocaine on Torpedo nicotinic acetylcholine receptors transplanted to Xenopus oocytes. JOURNAL OF NEUROCHEMISTRY. 1009-1019. 2011
- Solid-phase synthesis of a library of amphipatic hydantoins. Discovery of new hits for TRPV1 blockade. ACS CHEMICAL BIOLOGY. 458-465. 2011
- The role of the transient receptor potential vanilloid 1 (TRPV1) in inflammation and sepsis.. JOURNAL OF INFLAMMATION RESEARCH. 67-81. 2011
- Triazine-based Vanilloid-1 Receptor Open Channel Blockers: Design, Synthesis, Evaluation and SAR analysis.. JOURNAL OF MEDICINAL CHEMISTRY. 2011
- Ion binding to KcsA: implications in ion selectivity and channel gating. BIOCHEMISTRY. 9480-9487. 2010
- Occupancy of non-annular lipid Binding sites on kcsA greatly increases the stability of the tetrameric protein. . BIOCHEMISTRY. 5397-5404. 2010
- Interaction of transmembrane-spanning segments of the ¿2-adrenergic receptor with model membranes. MOLECULAR MEMBRANE BIOLOGY. 265-278. 2009
- : Protein self-assembly and lipid binding in the folding of the potassium channel KcsA.. BIOCHEMISTRY. 2123-2133. 2008
- Membranes: a meeting point for lipids and proteins. JOURNAL OF CELLULAR AND MOLECULAR MEDICINE. 829-875. 2008
- N-type inactivation of the potassium channel KcsA by the Shaker B "ball" peptide: mapping the inactivating peptide-binding epitope.. JOURNAL OF BIOLOGICAL CHEMISTRY. 18076-18085. 2008
- Protein-promoted membrane domains.. BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES. 1583-1590. 2008
- Interaction of the c-terminal region of the gamma-protein with model membranes.. BIOPHYSICAL JOURNAL. 2530-2541. 2007
- Antifungal effects and mechanism of action of viscotoxin A3. EUROPEAN JOURNAL OF BIOCHEMISTRY. 72-83. 2006
- Clustering and Coupled Gating Modulate the Activity in KcsA, a Potassium Channel Model. JOURNAL OF BIOLOGICAL CHEMISTRY. 18837-18848. 2006
- Effects of conducting and blocking ions on the structure and stability of the potassium channel kcsa.. JOURNAL OF BIOLOGICAL CHEMISTRY. 29905-29915. 2006
- Nicotinic acetylcholine receptor properties are modulated by the surrounding lipids: an ¿in vivo¿ study. JOURNAL OF MOLECULAR NEUROSCIENCE. 5-6. 2006
- Structural and functional changes induced in the nicotinic acetylcholine receptor by membrane phospholipids. JOURNAL OF MOLECULAR NEUROSCIENCE. 121-124. 2006
- The XII International Symposium on Cholinergic Mechanisms.. JOURNAL OF MOLECULAR NEUROSCIENCE. 1-2. 2006
- Proteomic analysis of apical microvillous membranes of syncitiothrophoblast cells reveals a high degree of similarity with lipid rafts. . JOURNAL OF PROTEOME RESEARCH. 2435-2441. 2005
- The influence of a membrane environment on the structure and stability of a prokaryotic potassium channel, KcsA. FEBS LETTERS. 5199-5204. 2005
- Unfolding and Refolding in Vitro of a Tetrameric, alpha-Helical Membrane Protein: The Prokaryotic Potassium Channel KcsA. BIOCHEMISTRY. 14344-14352. 2005
- Influence of C-terminal protein domains and protein-lipid interactions on tetramerization and stability of the potassium channel KcsA. BIOCHEMISTRY. 14924-14931. 2004
- Binding of the C-terminal Sterile {alpha} Motif (SAM) Domain of Human p73 to Lipid Membranes. JOURNAL OF BIOLOGICAL CHEMISTRY. 46878-46885. 2003
- Intrinsic Tyrosine fluorescence as a tool to study the interaction of the Shaker B ball peptide with anionic membranes. BIOCHEMISTRY. 7124-7132. 2003
- Probing The Channel-Bound Shaker B Inactivating Peptide By Stereoisomeric Substitution At A Strategic Tyrosine Residue.. BIOCHEMISTRY. 8879-8884. 2003
- Suscetibility of multidrug resistance tumor cells to apoptosis induction by histone deacetilase inhibitors. INTERNATIONAL JOURNAL OF CANCER. 579-586. 2003
- Protein orientation affects the efficiency of functional protein transplantation into the Xenopus oocyte membrane.. JOURNAL OF MEMBRANE BIOLOGY. 117-127. 2002
- Segregation of Phosphatidic Acid-Rich Domains in Reconstituted Acetylcholine Receptor Membranes. BIOCHEMISTRY. 12253-12262. 2002
- Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. BIOCHEMISTRY. 12253-12262. 2002
- Tyrosine Phosphorylation of the Inactivating Peptide of the Shaker B Potassium Channel: A Structural-Functional Correlate.. BIOCHEMISTRY. 12263-12269. 2002
- A protein G fragment from the salmonid VHS rhabdovirus induces cell-to-cell fusion and membrane phosphatidylserine translocation at low pH?. JOURNAL OF BIOLOGICAL CHEMISTRY. 46268-46275. 2001
- Human p8 is a HMG-I/Y protein with DNA binding activity enhanced by phosphorilation.. JOURNAL OF BIOLOGICAL CHEMISTRY. 2742-2751. 2001
- Multicentric reference values for some quantities measured with the Elecsys 2010 analyser.. CLINICA CHIMICA ACTA. 143-146. 2001
- Protein orientation affects the efficiency of functional protein transplantation into the Xenopus oocyte membrane?.. JOURNAL OF MEMBRANE BIOLOGY. 2001
- Structure and interaction with membrane model systems of a peptide derived from the major epitope region of HIV protein gp41. Implications on viral fusion mechanism.. BIOCHEMISTRY. 3196-3207. 2001
- Arginine rich peptides are blockers of VR- 1 channels with analgesic activity 2000
- Arginine rich peptides are blockers of VR-1 channels with analgesic activity. FEBS LETTERS. 131-136. 2000
- Human p8 is a HMG-like protein with DNA-binding activity enhanced by phosphorylation. 2000
- Altered drug membrane permeability in a multidrug-resistant Leishmania tropica line 1998
- Inactivating peptide of the Shaker B potassium channel: conformational preferences inferred from studies on simple model systems 1998
- Phospholipid interactions of a peptide from the fusion-related domain of the glycoprotein of VHSV, a fish rhabdovirus 1998
- Structural stabilization of botulinum neurotoxins by tyrosine phosphorylation 1998
chapter
- Structural and functional modulation of ion channels by specific lipids: from model systems to cell membranes. . Protein-lipid interactions. 203-233. 2006
- Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. Cholinergic Mechanisms: Function and Dysfunction. 665-669. 2004
- The segregation of a lipid domain underlies structural and functional modulation of acetylcholine receptor in reconstituted membranes. Xth international symposium on cholinergic mechanisms. From Torpedo electric organ to human brain: fundamental and applied aspects.. 432-433. 1998
- Lipid-protein interactions in reconstituted membranes containing nicotinicacetylcholine receptor . Spectroscopy of Biological Molecules: Modern Trends. 339-340. 1997
patent
- Peptidos capaces de bloquear la respuesta a sustancias químicas o estímulos térmicos o mediadorees de la inflamación de los nocieptores y composiciones que los contienen.
- Trímeros de N-alquilglicinas capaces de bloquear la respuesta a sustancias químicas, estímulos térmicos o mediadores de la inflación de los nociceptores, y composiciones que los contienen

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