Anualidad
Research Activity Report
Nuevos enfoque terapéuticos frente a la obesidad: modulación de la ingesta y el balance energético
¿CÓMO SE DESENCADENA EL DOLOR TRAS LA QUIMIOTERAPIA? ESTUDIANDO LOS CAMBIOS MOLECULARES PRODUCIDOS POR EL PACLITAXEL SOBRE LOS NOCICEPTORES UTILIZANDO UN MODELO IN VITRO PRECLÍNICO
COMPUESTOS ANTIBACTERIANOS DE SUBPRODUCTOS ALIMENTICIOS ¿PUEDEN HACER ALGO MÁS QUE MATAR BACTERIAS?
ThermoTRP channels in pain sexual dimorphism: new insights for drug intervention.
Discovery of new TRPM8 modulators and their therapeutic potential
Actas del segundo congreso anual internacional de estudiantes de doctorado de la Universidad Miguel Hernández de elche (CAIED)
ACTAS DEL SEGUNDO CONGRESO ANUAL INTERNACIONAL DE ESTUDIANTES DE DOCTORADO DE LA UNIVERSIDAD MIGUEL HERNÁNDEZ DE ELCHE (CAIED)
17ß-estradiol and the endocrine disruptor Bisphenol-A promote different ion channel regulation in the human beta cell line EndoC-ßH1.
IMMUNOMODULATORY LECTIN-LIKE PEPTIDES FOR FISH ERYTHROCYTES TARGETING AS POTENTIAL ANTIVIRAL DRUG DELIVERY PLATFORMS
A Novel VHSV Subunit Vaccine: A New Prophylactic Tool with Oral Delivery Potential
Study of toxicity of potential immunomodulating compounds for the development of oral metabolic therapies.
Transcriptome studies of viral hemorrhagic septicemia resistant and susceptible rainbow trout strains give insight into resistance associated immune pathways
Nanoestructuras poliméricas para encapsular metabolitos potencialmente inmunoestimulantes para acuicultura
Influence of drying temperature and harvesting season on phenolic content and antioxidant and antiproliferative activities of olive (Olea europaea) leaf extracts
Silibinin Suppresses the Hyperlipidemic Effects of the ALK-Tyrosine Kinase Inhibitor Lorlatinib in Hepatic Cells
Design of non-immunogenic peptides that prevent the activation of SARS-CoV-2 nsp14 and nsp16 proteins
Screening of Relevant Metabolism-Disrupting Chemicals on Pancreatic ß-Cells: Evaluation of Murine and Human In Vitro Models
Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche
Insights into the Conformational Dynamics of Potassium Channels Using Homo-FRET Approaches
Modelo pre-clínico para el estudio de las diferencias de género en procesos inflamatorios durante una crisis de migraña
Efecto del IFN¿ en la función de las células ¿ y ß pancreáticas
Absent in Melanoma 2 (AIM2) Regulates the Stability of Regulatory T Cells
Los canales iónicos Thermo TRP como clave molecular y funcional para la transducción del dolor neuropático en las neuronas somatosensoriales
Effect of the antitumoral drug verteporfin on the replication of spring viraemia of carp virus (SVCV)
Endocrine disruptors and pancreatic beta cells
Pre-clinical model for the study of gender dimorphism in inflammatory processes during a migraine attack
ACTUALIZACIÓN SOBRE LAS TÉCNICAS DE EXTRACCIÓN DE COMPUESTOS DEL CÁNNABIS Y MÉTODOS ANALÍTICOS PARA LA CARACTERIZACIÓN DE LOS COMPUESTOS
In Vitro and In Vivo Pharmacological Characterization of a Novel TRPM8 Inhibitor Chemotype Identified by Small-Scale Preclinical Screening
Intra-variability in IB4- and IB4+ DRG neurons: a population of models study
The effects of aging on pancreatic ß-cell function involve multiple events in the regulation of insulin secretion.
How modular protein nanoparticles may expand the ability of subunit anti-viral vaccines: The spring viremia carp virus (SVCV) case
Design of non-immunogenic peptides that prevent the activation of SARS-CoV_2 nsp14 and nsp16 proteins
Development of a compound as neurocosmetic ingredient to alleviate allodynia symptoms induced by chemotherapy-
Reusable fluorescent nanobiosensor for screening and quantification of antidiabetic drugs
STUDY OF THE ANTIVIRAL PROPERTIES OF HIBISCUS, GREEN TEA, ECHINACEA AND GRAPE SKIN EXTRACTS AGAINST THE VIRAL HEMORRHAGIC SEPTICEMIA VIRUS
Paclitaxel in vitro reversibly sensitizes the excitability of IB4(-) and IB4(+) sensory neurons from male and female rats
Role of estrogen receptor B on K channel regulation in the human beta cell line EndoC-ßH1
La célula beta pancreática y el reto metabólico del embarazo: buscando las causas de la diabetes mellitus gestacional
Modulation of Cholesterol Pathways in Human Macrophages Infected by Clinical Isolates of Leishmania infantum
Inhibition of the infection of several fish viruses of distinct families with probable serineand low-pH-dependent entry by NK-lysin
Paclitaxel and Oxaliplatin Sensitizing Effects and Sex Differences on Pre-Clinical In vitro Models of Chemotherapy-Induced Peripheral Neuropathy
Amino acid-derived ß¿lactams: TRPM8 antagonists with analgesic activity in different pain models.
Conformational plasticity of the potassium channel KcsA: lipid and ion modulation
Proteomics and flow cytometry give new insight into immunosuppression observed during carp edema virus-induced gill disease
Valorización de la paja de arroz como subproducto agrícola
Natural extracts for application as antiviral in aquaculture against red grouper nervous necrosis virus
Fabrication of electrospun nanofibers loaded with piscidin for antibacterial applications
A MODULAR PLATFORM PROTEIN VACCINE AGAINST VHSV FOR ORAL DELIVERY
DESCUBRIMIENTO DE NUEVOS MODULADORES DE TRPM8 Y SU POTENCIAL TERAPÉUTICO
PIEU-A/2021/08: Programa TFGi: trabajos de fin de grado interdisciplinares
Liposomas termosensibles como soporte para modular la banda plasmónica de nanopartículas de oro: diseño de nanohibridos con aplicaciones en quimioterapia y terapia fototérmica
The current status and future prospects for therapeutic targeting of KEAP1-NRF2 and beta-TrCP-NRF2 interactions in cancer chemoresistance
Regulation of potassium ion channels by 17ß-estradiol and the endocrine disruptor Bisphenol-A in the human beta cell line EndoC-ßH1
A small dose of intraarticular triamcinolone plus mepivacaine provides a rapid and sustained relief for gout flares
Structural consequences on the selectivity filter of the potassium channel KcsA by anionic lipids.
The pancreatic beta-cell in ageing: Implications in age-related diabetes
LA SOBREEXPRESIÓN DE BCL-XL COMO ESTRATEGIA PARA PROTEGER A LAS CÉLULAS BETA PANCREÁTICAS DE LA APOPTOSIS INDUCIDA POR CITOQUINAS PROINFLAMATORIAS EN LA DIABETES TIPO 1
¿Amistades peligrosas¿: Obesidad y los disruptores endocrinos.
Redefining the intracellular final effectors of verbascoside that alleviate glucotoxicity-induced oxidative stress in hypertrophic adipocytes
New regulation on medical devices made of substances: Opportunities and challenges for pharmacological and toxicological research
G protein-coupled estrogen receptor activation by bisphenol-A disrupts the protection from apoptosis conferred by the estrogen receptors ER¿ and ERß in pancreatic beta cells
Fabrication of PEO electrospun nanofibers loaded with piscidin for antibacterial applications
Nile Tilapia Strain Resistant to Tilapia Lake Virus Disease ¿ Immunological and Implementation Considerations
IDENTIFICACIÓN DE NUEVAS DIANAS TERAPÉUTICAS PARA EL TRATAMIENTO DE LA DIABETES TIPO 1 BASADAS EN LAS ESTRATEGIAS DE SUPERVIVENCIA DE LAS CÉLULAS ALFA PANCREÁTICAS
Gender differences in scratching behaviour
¿Nuevos enfoques terapéuticos frente a la obesidad: modulación de la ingesta y el balance energético¿
Evaluación del dimorfismo sexual en la sensibilización de TRPA1 durante una crisis de migraña
Contribution of CD4+ cells in the emotional alterations induced by endometriosis in mice
Proteomics Give New Insight into Pathology and Immunosuppression Observed During Carp Edema Virus-Induced Gill Disease
Clinical and Immunological Factors Associated with Recommended Trough Levels of Adalimumab and Infliximab in Patients with Crohn's Disease
Silibinin Overcomes EMT-Driven Lung Cancer Resistance to New-Generation ALK Inhibitors
Optimización y caracterización de nanofibras electrohiladas con albúmina de suero bovino
DIETARY SALT INTAKE AFFECTS THE TH17-DEPENDENT INFLAMMATORY PROFILE OF PATIENTS WITH CIRRHOSIS
TÉCNICAS DE EXTRACCIÓN DE COMPUESTOS DEL CÁNNABIS Y MÉTODOS ANALÍTICOS PARA LA CARACTERIZACIÓNÓN DE LOS COMPUESTOS
Subproductos Alimentarios como Fuente de Prebióticos y para Procesos de Encapsulación
Optimization and characterization of electrospun nanofibers with bovine serum albumin
Direct conversion of human foetal lung fibroblasts to sensory neurons.
Antiviral activity of Mediterranean aromatic plants against viruses of interest in aquaculture
Uso de plantas medicinales en la mejora de la salud desde una perspectiva científica.
¿Qué parte del cerebro me avisa del picor?
Tailoring the plasmonic properties of gold-liposome nanohybrids as a potential powerful tool for light-mediated therapies
Diseño computacional y validación funcional de nuevos péptidos moduladores de las isoformas fosfolipasa C beta
Moderación mesa redonda sobre salidas profresionales
Envelope E protein of dengue virus and phospholipid binding to the late endosomal membrane
Immigrant IBD Patients in Spain Are Younger, Have More Extraintestinal Manifestations and Use More Biologics Than Native Patients.
Operant Self-medication for Assessment of Spontaneous Pain Relief and Drug Abuse Liability in Mouse Models of Chronic Pain
Absent in melanoma 2 (AIM2) regulates the stability of T regulatory cells
Elaboración de nanofibras de biopolímeros basados en quitosano como sistema de liberación de fármacos antineoplásicos en un modelo in vitro de glioblastoma
The Immune System of Marine Organisms as Source for Drugs against Infectious Diseases
AN USER-FRIENDLY HAND-HELD BIOSENSOR FOR DETECTION OF WATER POLLUTANTS
Pulsed-Xenon Ultraviolet Light Highly Inactivates Human Coronaviruses on Solid Surfaces, Particularly SARS-CoV-2
Identification of natural compounds that alleviate obesity-disturbances in human adipocytes
Bioactive Antioxidant Compounds from Chestnut Peels through Semi-Industrial Subcritical Water Extraction
ANTIVIRAL EVALUATION OF A NOVEL PROPHYLACTIC TOOL FOR THE PREVENTION OF VIRAL DISEASES IN FISH
Xenopus Oocytes as a Powerful Cellular Model to Study Foreign Fully-Processed Membrane Proteins
Modelos traslacionales de dolor: Investigación preclínica sobre el dimorfismo sexual de la migraña crónica.
Terapias metabólicas para el tratamiento de enfermedades infecciosas en peces de cultivo
Paclitaxel and Oxaliplatin Effects on Pre-clinical In vitro Models of Chemotherapy-Induced Peripheral Neuropathy of Male and Female Rat DRG Neurons
Study of altered hormone expression in obese subjects related to appetite and satiety signalling.
TRPM8 channel antagonists for relieving pain in chemotherapy-induced peropheral neuropathy
Interaction of Lassa virus fusion and membrane proximal peptides with late endosomal membranes
HIGH SALT DIET ENHANCES THE PRESENCE OF Th17 CELLS IN THE LIVER AND AFFECTS THE DEVELOPMENT OF CHEMICALLYINDUCED HEPATOCELLULAR CARCINOMA IN MICE
Papel de los receptores de estrógenos en la apoptosis de la célula ß pancreática
Aggressive versus moderate fluid resuscitation in acute pancreatitis, a multi-center randomized clinical trial (WATERFALL trial)
Conformational plasticity of ion channels: a fluorescence-based approach
Cytoskeleton altering drugs and peripheral nerve neurons as a combinatorial therapy for spinal cord injury
Editorial: The role of red blood cells in the immune response of fish
Direct conversion of human fibroblasts to sensory neurons
Vimentin as a regulator of cell survival and endoplasmic reticulum stress in pancreatic alpha and beta cells
Don¿t Let It Get Under Your Skin! ¿ Vaccination Protects the Skin Barrier of Common Carp From Disruption Caused by Cyprinid Herpesvirus 3
Fish Innate Immune Response to Viral Infection¿An Overview of Five Major Antiviral Genes
G protein-coupled estrogen receptor activation by Bisphenol-A disrupts protection from apoptosis conferred by estrogen receptors ER¿ and ERß in pancreatic beta cells
Relación estructura-función en canales iónicos
Biochemical and biophysical characterization of PADI4 supports its involvement in cancer
Long-term perturbation of the peripheral immune system months after SARS-CoV-2 infection
Cellular signaling, molecular activation and regulation of the AIM2 inflammasome
Textbook outcome among patients undergoing enhanced recovery after liver transplantation stratified by risk. A single-center retrospective observational cohort study
CARACTERIZACIÓN Y COMPARACIÓN DE NANOFIBRAS POLIMÉRICAS ELECTROHILADAS CON ALTO CONTENIDO EN PROTEÍNAS DE DISTINTO PESO MOLECULAR
Insulin-degrading enzyme ablation in mouse pancreatic alpha cells triggers cell proliferation, hyperplasia and glucagon secretion dysregulation
In vitro pre-clinical nociceptor model: useful tool for modelling Chemotherapy Induced-Neuropathic Pain (CIPN)
Risk of Colorectal Cancer and Advanced Polyps One Year After Excision of High-Risk Adenomas
Diseño de péptidos moduladores de las isoformas fosfolipasa C beta
Early postoperative complications after gastric bypass revisional surgery in patients with previous sleeve gastrectomy versus primary gastric bypass
An user-friendly hand-held biosensor for detection of water pollutants
New clues to the genesis of hyperglucagonemia: insulin-degrading enzyme
Androgenic TRPM8 1 activity drives sexual dimorphism in a murine model of chronic migraine.
High global antioxidant protection and stimulation of the collagen synthesis of new anti-aging product containing an optimized active mix
Evaluación de inhibidores de la vía de interferón como nuevas terapias para la diabetes tipo 1
In vitro pre-clinical nociceptor model: useful tool for modelling Chemotherapy Induced-Neuropathic Pain
SOFT X-RAY CRYO-TOMOGRAPHY REVEALS THAT ENDOPLASMIC RETICULUM PLAY AN ACTIVE ROLE IN RAINBOW TROUT ERYTHROCYTES ANTIVIRAL IMMUNE RESPONSE
The immunolocalization of HIF-2¿, GLUT1 and CAIX in porcine oviduct during the estrous cycle
Aging and alterations in pancreatic alpha and beta-cells: implication in age-related diabetes.
Disposable electrochemical biosensor based on the inhibition of Alkaline Phosphatase encapsulated in acrylamide hydrogels
The role of European Sea Bass red blood cells in nervous necrosis virus infection
Migraine-related vulnerability involves TRPA1 and androgenic TRPM8 activity in mice
New chiral heterocyclic compounds with potent TRPM8 antagonist activity
Actividad viricida de materiales de poliuretano termoplástico con nanopartículas de plata
TRPV1 in chronic pruritus and pain: Soft modulation as a therapeutic strategy
Testosterone-TRPM8 interactions drive pain resilience in a mouse model of chronic migraine
Role of the sigma-1 receptor in the pathophysiology of osteoarthritis pain
NK-Lysin Inhibits the Replication of Several Fish Viruses From Different Families With Low pH-Mediated Entry
Conformational buffering underlies functional selection in intrinsically disordered protein regions
In vitro assays to identify metabolism-disrupting chemicals with diabetogenic activity in a mouse pancreatic alpha-cell model
EFECTO MODULADOR DE LOS FÁRMACOS BETABLOQUEANTES NO SELECTIVOS SOBRE LOS SISTEMAS INMUNE Y ADRENÉRGICO Y SU RELACIÓN CON LA MORTALIDAD Y EL HEPATOCARCINOMA EN PACIENTES CON CIRROSIS
Conversión directa de fibroblastos fetales de pulmon a neuronas sensoriales
Direct conversion of foetal lung fibroblasts to sensory neurons
The vascular niche for adult cardiac progenitor cells
ß-Lactam TRPM8 antagonist RGM8-51 displays analgesic activity in different animal models
Thermo TRP ion channels as a key molecular and functional landmark for neuropathic pain transduction in subsets of somatosensory neurons
PLC beta peptides to modulate the activity of TRP channels
In vitro models to study the adipocyte-tumor microenvironment and its impact on the metabolism of colon cancer cells
Study of altered hormone expression in obese subjects related to appetite and satiety signalling
Prediction of peritoneal soiling in acute appendicitis with simple clinical and laboratory data. Prospective, multicenter, cohort study of 2,645 adult patients nationwide
SARS-CoV-2 Omicron variant escapes neutralizing antibodies and T cell responses more efficiently than other variants in mild COVID-19 convalescents
Modulation of Oxidative Stress and Antioxidant Response by Different Polyphenol Supplements in Five-a-Side Football Players
Identification of Leukemia-Associated Immunophenotypes by Databaseguided Flow Cytometry Provides a Highly Sensitive and Reproducible Strategy for the Study of Measurable Residual Disease in Acute Myeloblastic Leukemia
Probing the dynamics of the selectivity filter of the NaK channel: consequences on ion selectivity and inactivation.
Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2022
ANTIVIRAL FUNCTION OF NKEF AGAINST VHSV IN RAINBOW TROUT
Caracterización de un péptido de diseño con potencial inhibidor del virus del ZIKA
An inhibitor of interaction between the transcription factor NRF2 and the E3 ubiquitin ligase adapter beta-TrCP delivers anti-inflammatory responses in mouse liver
Concurrent vaccination of kidney transplant recipients and close household cohabitants against COVID-19
Immunological insights into the resistance of Nile tilapia strains to an infection with tilapia lake virus
Environmental surveillance and clinical assessment of SARS-CoV-2 epidemiology and variant prevalence in an urban area in Spain
Silica/Proteoliposomal Nanocomposite as a Potential Platform for Ion Channel Studies
Electrospun fibers of Poly(methyl vinyl ether-alt- maleic anhydride) and L-Menthol for treatment of plantar fasciitis
Procyanidin C1 Location, Interaction, and Aggregation in Two Complex Biomembranes
Thermoplastic polyurethane films with silver nanoparticles as promising antiviral materials
Diabetes durante el embarazo: buscando las causas.
Endocrine disruptors as environmental determinants of diabetes mellitus
New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models
PDX1-ALX3-GPR40 axis promotes glucose responsiveness and insulin secretion in pancreatic beta-cells
Combinatorial pathway disruption is a powerful approach to delineate metabolic impacts of endocrine disruptors
In Vitro Assays to Identify Metabolism-Disrupting Chemicals with Diabetogenic Activity in a Human Pancreatic ß-Cell Model
New chiral heterocyclic amino acid derivatives as TRPM8 antagonists.
Targeting endogenous analgesia systems for endometriosis treatment
Cinética de extracción de compuestos polifenólicos en altramuz (Lupinus Angustifolius): Influencia del tamaño de partícula y temperatura
Cooperation between ER stress, autophagy, mitochondrial stress and vesicle trafficking in the RBCs response to vaccines
Identificación y Caracterización de nuevos moduladores de TRPM8.
DESARROLLO DE NUEVAS NANOFORMULACIONES TERAPEÚTICAS
INVOLVEMENT OF TRANSIENT RECEPTOR POTENTIAL CHANNELS IN THE SEXUAL DIMORPHISM OF A MOUSE MODEL OF CHRONIC MIGRAINE
Aggressive or Moderate Fluid Resuscitation in Acute Pancreatitis
A topical formulation of a soft TRPV1 antagonist (AG1549) alleviates chemotherapyinduced peripheral neuropathy symptoms.
Assessment of pancreatic ß-cell function as a tool to identify diabetogenic chemicals
CAMBIOS INMUNOLÓGICOS Y ADRENÉRGICOS EN PACIENTES CIRRÓTICOS TRATADOS CON ESTATINAS
Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression
The outcome of boosting mitochondrial activity in alcoholic liver disease (ALD) is organ-dependent
Oxaliplatin time course effect on a pre-clinical in vitro model of male and female rat DRG neurons.
DETERMINATION OF THE OPTIMAL HARVEST TIME BY HPLC OF THE TOTAL POLYPHENOLIC CONTENT IN CISTUS ALBIDUS L. AS A MEDICINAL PLANT
Identification of endocrine disruptors with diabetogenic activity using pancreatic beta cells
Desarrollo de Nanopartículas Multifuncionales Fotosensibles
Papel de los receptores de estrógenos y de los disruptores endocrinos en la diabetes
Factors associated with lesion detection in colonoscopy among different indications
The pancreatic alpha-cell: old stories and new challenges in diabetes.
Vimentin as a regulator of cell survival and endoplasmic reticulum stress in pancreatic alpha- and beta-cells
GRUPO EXPERIMENTACIÓN BÁSICA EN DIABETES DE LA SED: Vimentin as a regulator of cell survival and endoplasmic reticulum stress in pancreatic ¿- and ß-cells
Molecular Events behind the Selectivity and Inactivation Properties of Model NaK-Derived Ion Channels
RDF description of Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2022 - http://research.umh.es/vivo/pub/memoria/2022/org_10874