selected publications
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academic article
- Experimental resistance to drug combinations in Leishmania donovani: metabolic and phenotypic adaptations. ANTIMICROBIAL AGENTS AND CHEMOTHERAPY. 2242-2255. 2015
- Liver damage and caspase-dependent apoptosis is related to protein malnutrition in mice: effect of methionine.. ACTA HISTOCHEMICA. 126-135. 2015
- A comprehensive Foodomics study on the mechanisms operating at various molecular levels in cancer cells in response to individual rosemary polyphenols. ANALYTICAL CHEMISTRY. 1-9. 2014
- Liver damage and caspase-dependent apoptosis is related to protein malnutrition in mice: effect of methionine. ACTA HISTOCHEMICA. 1-30. 2014
- Resistance to Selumetinib (AZD6244) en colorectal cancer cell lines is mediated by p70S6K and RPS6 activation.. NEOPLASIA. 845-860. 2014
- "Effect of dietary polyphenols on K562 leukemia cells: A Foodomics approach". ELECTROPHORESIS. 2314-2327. 2012
- Acquisition of MDR Phenotype by Leukemic Cells Is Associated With Increased Caspase-3 Activity and a Collateral Sensitivity to Cold Stress. JOURNAL OF CELLULAR BIOCHEMISTRY. 1416-1425. 2012
- Application of nanoLC-ESI-TOF-MS for the metabolomic analysis of phenolic compounds from extra-virgin olive oil in treated colon-cancer cells. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS. 128-134. 2012
- Dual regulation of P-glycoprotein expression by Trichostatin A in cancer cell lines. BMC MOLECULAR BIOLOGY. 25-34. 2012
- Dual regulation of P-glycoprotein expression by Trychostatin A in cancer cell lines. BMC MOLECULAR BIOLOGY. 25-47. 2012
- Effect of rosemary polyphenols on human colon cancer cells: transcriptomic profiling and functional enrichment analysis.. GENES AND NUTRITION. 3-9. 2012
- Formation and relevance of 5-hydroxymethylfurfural in bioactive subcritical water. FOOD RESEARCH INTERNATIONAL. 31-37. 2012
- Global Foodomics strategy to investigate the health benefits of dietary constituents¿. JOURNAL OF CHROMATOGRAPHY A. 139-153. 2012
- Study of the anticancer properties of tin (IV) carboxylate complexes on a panel of human tumor cell lines. CHEMMEDCHEM. 301-310. 2012
- ¿CE/LC-MS Multiplatform for Broad Metabolomic Analysis of Dietary Polyphenols Effect on Colon Cancer Cells Proliferation". ELECTROPHORESIS. 2328-2336. 2012
- Acquisition of MDR phenotype by leukemic cells associates with an increase of caspase-3 activity and a collateral sensitivity to cold stress. JOURNAL OF CELLULAR BIOCHEMISTRY. 2011
- Is metabolomics reachable? Different purification strategies of human colon cancer cells provide different CE-MS metabolite profiles. ELECTROPHORESIS. 1765-1777. 2011
- Small tyrosine kinase inhibitors interrupt EGFR signalling by interacting with erbB3 and erbB4 in glioblastoma cell lines. EXPERIMENTAL CELL RESEARCH. 1476-1489. 2011
- Uptake of the antileishmania drug tafenoquine follows a sterol-dependent diffusion process in Leishmania.. JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY. 2562-2565. 2011
- Serine proteases in histone deacetylase inhibitor-induced apoptosis still an unresolved question. MOLECULAR CANCER THERAPEUTICS. 2441-2443. 2010
- Inhibition of Hsp90 function by ansamycins causes downregulation of cdc2 and cdc25c and G2/M arrest in glioblastoma cell lines. ONCOGENE. 7185-7193. 2007
- Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines. . MOLECULAR CANCER RESEARCH. 641-653. 2007
- Protein kinase C-alpha antagonizes apoptosis induction by histone deacetylase inhibitors in multidrug resistant leukaemia cells. . INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY. 1877-1885. 2007
- p53 genetic abnormalities and P-glycoprotein expression in stump and primary gastric carcinomas. HEPATO-GASTROENTEROLOGY. 377-381. 2007
- Inhibition of Hsp90 function causes dowregulation of cdc2 and cdc25C and G2/M arrest in glioblastoma cell lines. . ONCOGENE. 2006
- Structural and functional changes induced in the nicotinic acetylcholine receptor by membrane phospholipids. JOURNAL OF MOLECULAR NEUROSCIENCE. 121-124. 2006
- Acquisition of multidrug resistance by L1210 leukemia cells decreases their tumorigenicity and enhances their susceptibility to the host immune response. CANCER IMMUNOLOGY IMMUNOTHERAPY. 328-336. 2005
- Design and synthesis of an optimized positional scanning library of peptoids: identification of novel multidrug resistance reversal agents. BIOORGANIC & MEDICINAL CHEMISTRY. 1923-1929. 2005
- Differentiation and drug resístanse relationships in leukemia cells. JOURNAL OF CELLULAR BIOCHEMISTRY. 98-108. 2005
- Histone deacetylase inhibitors induced caspase-independent apoptosis in human pancreatic adenocarcinoma cell lines.. MOLECULAR CANCER THERAPEUTICS. 1222-1230. 2005
- Multdrug resistance-associated protein(MRP1) gene is strongly expressed in gastric carcinomas.Analysis by inmunohistochemistry and real-time quantitative RT-PCR. HISTOPATHOLOGY. 389-395. 2005
- Trimers of n-alkylglycines are potent modulators of the multidrug resistance phenotype . JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 112-120. 2005
- P53 regulation of estrogen receptor-á expression in MCF-7 cells. JOURNAL OF ENDOCRINOLOGY. 497-504. 2004
- Synthesisof a library of 3-oxopiperazinium and (6H)-3-oxohexahydro-1,4-diazepinium derivatives and identification of bioactive compounds . JOURNAL OF COMBINATORIAL CHEMISTRY. 135-141. 2004
- Taxol regulation of estrogen receptor-á expression in MCF-7 cells. JOURNAL OF ENDOCRINOLOGY. 487-496. 2004
- Suscetibility of multidrug resistance tumor cells to apoptosis induction by histone deacetilase inhibitors. INTERNATIONAL JOURNAL OF CANCER. 579-586. 2003
- Protein orientation affects the efficiency of functional protein transplantation into the Xenopus oocyte membrane.. JOURNAL OF MEMBRANE BIOLOGY. 117-127. 2002
- Segregation of Phosphatidic Acid-Rich Domains in Reconstituted Acetylcholine Receptor Membranes. BIOCHEMISTRY. 12253-12262. 2002
- Segregation of phosphatidic acid-rich domains in reconstituted acetylcholine receptor membranes. BIOCHEMISTRY. 12253-12262. 2002
- Trichostatin A effects in different drug-resistant tumor cell lines. ACTA DIABETOLOGICA. 175-179. 2002
- Trichostatin A effects in different drug-resistant tumor cell lines.. ACTA DIABETOLOGICA. 175-179. 2002
- Protein orientation affects the efficiency of functional protein transplantation into the Xenopus oocyte membrane?.. JOURNAL OF MEMBRANE BIOLOGY. 2001
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chapter
- Cell Death and Cancer. Novel Therapeutic Strategies. apoptosis and medicine. 67-110. 2012
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congress communication
- Bioactive compounds of Rosmarinus officinalis against colon cancer cell lines and histopathological evaluation of oral acute toxicity in rats exposed to the extract 2014
- Actividad antitumoral de extractos de Rosmarinus officinalis obtenidos por CO2 supercrítico y sus fracciones en modelos celulares de cáncer de colon 2013
- Differential effects of EGFR inhibitors in pancreatic carcinoma cell lines. 69-69. 2010
- Extra Virgin Olive Oil Phenolic Extract (EVOOPE) prevents human colon adenocarcinoma growth. A Metabolomic approach. 186-186. 2010
- HGUE-C-1 a novel colon carcinoma cell line. 197-198. 2010
- Metabolomic Study of Human HT29 colon cancer cells by CE-MS. A comparative study of metabolite purification strategies. 341-341. 2010
- Overcoming chemorresistance in pancreatic and colorectal cell lines. 71-71. 2010
- Protein malnutrition activates caspase-independent apoptosis in mouse liver .Methionine protection. 65-65. 2010
- Study of the regulation of DUSP6 expression as a chemorresistance mechanisms in exocrine pancreatic cancer. 56-56. 2010
- Alteration of MAPK signalling pathways in multidrug resistant and P-GP-transfected leukaemic cell lines. 70-70. 2009
- Implication of P-glycoprotein on cold stress induced-cell-death in a leukemic cell line by a caspases-dependent mechanisms. 91-91. 2009
- Kinase inhibitors as therapeutical tools for colorectal cancer. 93-93. 2009
- Multidrug resistance and apoptosis in human leukaemic cell lines. 386-386. 2009
- Regulation of P-glycoprotein and multidrug resistance protein expression by histone deacetylase inhibitors in cancer cells. 62-62. 2009
- Relationship between apoptosis, cell differentiation and multidrug resistance in human leukaemic cells.. 104-104. 2009
- Targeting tyrosine kinase receptors in glioblastoma multiforme. 111-112. 2009
- Cold Stress induces apoptosis in a multidrug resistant leukaemic cell line by a caspases-dependent mechanism. 76-76. 2008
- Implication of MAPK signalling pathways on cold stress-induced apoptosis in a multidrug resistant leukaemic cell line. 144-144. 2008
- Insights into histone deacetylase inhibitors-induced apoptosis in cancer cell lines. 28-28. 2008
- La diferenciación celular modula la resistencia a apoptosis en lineas de leucemia humana 2008
- TSA regulates P-glycoprotein and multidrug resistance associated protein expression in cancer cells. 136-137. 2008
- Epidermal growth factor receptor inhibition reduces cell proliferation of glioblastoma multiforme cell lines. . 45-45. 2007
- La inhibición de rutas de transducción de señales como estrategia terapéutica en glioblastoma multiforme 2007
- Muerte celular programada inducida por los inhibidores de desacetilasas de histonas.¿Un mecanismo común, o múltiples mecanismos dependientes del modelo celular? 2007
- PARP-1 inhibitors potentiate the histone deacetylase inhibitors-induced apoptosis in tumour cell lines from different origin. 44-44. 2007
- PKC-alfa antagoniza el efecto apoptótico inducido por los inhibidores de las desacetilasas de histonas 2007
- Post-transcriptional regulation of P-glycoprotein expression in cancer cell lines 2007
- Regulation of MDR1 gene expression, role of the histone deacetylase inhibitors. 24-24. 2007
- Study of the interaction between trichostatin and rapamycin in pancreatic-adenocarcinoma cell lines. 43-43. 2007
- Geldanamycin causes a G2/M arrest in glioblastoma cell lines 2006
- Insights on histone deacetylase inhibitors-induced apoptosis in hematopoietic cell lines 2006
- Insights on histone deacetylase inhibitors-induced apoptosis in pancreatic adenocarcinoma cell lines 2006
- Los inhibidores de PARP-1 potencian la apoptosis inducida por los inhibidores de las desacetilasas de histonas en diversas líneas celulares tumorales 2006
- Los inhibidores de las desacetilasas de histonas en el tratamiento del cáncer 2006
- Desarrollo y evaluación de nuevos abordajes terapéuticos y de modelos de experimentación animal para el tratamiento del carcinoma de páncreas exocrino 2005
- La apoptosis inducida por los inhibidores de las desacetilasas de histonas es dependiente de la actividad de una o varias serín-proteasas en varios modelos celulares quimiorresistentes 2005
- Los inhibidores de PARP-1 potencian la apoptosis inducida por los inhibidores de desacetilasas de histonas en diversas líneas celulares tumorales 2005
- Los inhibidores de las desacetilasas de histonas (iHDACs) inducen apoptosis caspasa-independiente y serín proteasa-dependiente en líneas celulares de adenocarcinoma humano de páncreas exocrino 2005
- Phosphatidic acid modulates the properties of nicotinic acetylcholine receptors transplanted to Xenopus oocytes 2005
- Regulación postranscripcional de glicoproteína P en líneas celulares de carcinoma humano de colon 2005
- Structural and functional changes induced in the nicotinic Acetylcholine Receptor by membrane phospholipids. 2005
- La activación de PKC alfa en lineas celulares hematopoyeticas las protege de la inducción de apoptosis por inhibidores de las desacetilasas de histonas 2004
- La inducción de apoptosis en líneas celulares de carcinoma de páncreas exocrino por los inhibidores de las deacetilasas de histonas es independiente de la activación de las caspasas 2004
- Mecanismos de apoptosis inducidos por tricostatina A en líneas celulares de leucemia murina y humana 2004
- Mecanismos de inducción de apoptosis en líneas celulares de adenocarcinoma de páncreas por inhibidores de las desacetilasas de histonas 2004
- Mecanismos de inducción de apoptosis por los inhibidores de las deacetilasas de histonas en líneas celulares de leucemia murina y humana 2004
- Phosphatidic acid modulates the properties of nicotinic acetylcholine receptors transplanted to Xenopus oocytes. 2004
- : Post-transcriptional regulation of P-glycoprotein expresión in human colon carcinoma cell lines 2003
- Efectos de la tricostatina A en la expresión de MSH6, MSH2, MLH1 y MGMT en líneas celulares de carcinomas humanos 2003
- Efectos de la tricostatina A en la expresión de MSH6, MSH2, MLH1 y MGMT en líneas celulares de carcinomas humanos 2003
- Inducción de apoptosis mediada por los inhibidores de las desacetilasas de histonas en líneas celulares de carcinoma pancreático humano 2003
- Papel de las PKC clásicas en la resistencia a los inhibidores de las desacetilasas de histonas en la línea celular de leucemia múrina L1210 2003
- Post-transcriptional regulation of P-glycoprotein expression in human colon carcinoma cell lines 2003
- Post-transcriptional regulation of P-glycoprotein expression in human colon carcinoma cell lines 2003
- Regulación postranscripcional del gen MDR1 en líneas celulares de carcinoma de colon: Implicaciones en el análisis de la quimiorresistencia de las células tumorales 2003
- Regulación postranscripcional del gen MDR1 en líneas celulares de carcinoma de colon: implicaciones en el análisis de la quimiorresistencia de las células tumorales. 2003
- Different signal transduction pathways interfere with histone deacetylase inhibitors induced apoptosis in murine leukemia cells bearing MDR phenotype 2002
- Inducción de apoptosis por inhibidores de las desacetilasas de histonas en líneas celulares de carcinoma de páncreas humano 2002
- P-glycoprotein regulation by histone deacetylase inhibitors in tumor cell bearing multiple drug resistance phenotype (MDR) 2002
- P-glycoprotein regulation by histone deacetylase inhibitors in tumor cell bearing multiple drugs resistance phenotype (MDR) 2002
- Regulation of P-glycoprotein expression and activity in cancer cells: Identification of a possible translational mechanism 2002
- Regulation of P-glycoprotein expression and activity in cancer cells: Identification of a possible translational mechanism 2002
- Selective apoptosis induction by histone deacetylase inhibitors in tumor cell bearing a Multidrug- resistance phenotype (MDR) 2002
- Selective apoptosis induction by histone deacetylase inhibitors in tumor cell bearing a multidrug-resistant phenotype (MDR) 2002
- Identificación a partir de quimotecas combinatorias de nuevos reversores del fenotipo MDR 2000
- Efecto de la Tricostatina-A en células de leucemia murina y relación con el fenómeno MDR 1999
- Fenotipo de resistencia a múltiples fármacos y maduración celular inducida en una línea de leucemia mieloide humana 1999
- Regulación del gen del receptor de estrógenos tipo alfa por p53 en células MCF-7 1999
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patent