VALOR BECERRA, LUIS MIGUEL
Positions
- PDI INVESTIGADOR, Instituto de Investigación, Desarrollo e Innovación en Biotecnología Sanitaria de Elche 2023 -
- Profesor/a Asociado/a, Bioquímica y Biología Molecular 2022 -
- INVESTIGADOR CSIC, Instituto de Neurociencias 2013 - 2014
- INVESTIGADOR RAMÓN Y CAJAL CSIC, Instituto de Neurociencias 2009 - 2012
- INVESTIGADOR CSIC, Instituto de Neurociencias 2007 - 2008
- GRUPO 2: BECAS A TITULADOS DE GRADO MEDIO Y SUPERIOR, Instituto de Neurociencias 2002
- FPI-GENERALITAT VALENCIANA, Instituto de Neurociencias 1998 - 2001
- Publications
- Research
- Teaching
- Contact
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Publications
selected publications
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academic article
- Defining a Correlative Transcriptional Signature Associated with Bulk Histone H3 Acetylation Levels in Adult Glioblastomas. CELLS. 1-15. 2023
- MicroRNAs in the Mouse Developing Retina. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-20. 2023
- Molecular Research on Huntington¿s Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-2. 2023
- A Glimpse of Molecular Biomarkers in Huntington's Disease. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-15. 2022
- CBP Is Required for Establishing Adaptive Gene Programs in the Adult Mouse Brain.. JOURNAL OF NEUROSCIENCE. 7984-8001. 2022
- Genomic landscape of transcriptional and epigenetic dysregulation in early-onset polyglutamine disease. JOURNAL OF NEUROSCIENCE. 10471-10482. 2013
- Genomic targets, and histone acetylation and gene expression profiling of neural HDAC inhibition. NUCLEIC ACIDS RESEARCH. 8072-8084. 2013
- Lysine acetyltransferases CBP and p300 as therapeutic targets in cognitive and neurodegenerative disorders. CURRENT PHARMACEUTICAL DESIGN. 5051-5064. 2013
- Expression and functional properties of ¿7 acetylcholine nicotinic receptors are modified in the presence of other receptor subunits. JOURNAL OF NEUROCHEMISTRY. 1-35. 2012
- Hippocampal gene profiling: toward a systems biology of the hippocampus. HIPPOCAMPUS. 929-941. 2012
- Ablation of CBP in forebrain principal neurons causes modest memory and transcriptional defects and a dramatic reduction of histone acetylation, but does not affect cell viability. JOURNAL OF NEUROSCIENCE. 1652-1663. 2011
- CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement. EMBO JOURNAL. 4287-4298. 2011
- CREB is as a primary hub of activity-driven neuronal gene expression. JOURNAL OF NEUROSCIENCE. 1-1. 2011
- Ultrastructural and transcriptional profiling of neuropathological misregulation of CREB function. CELL DEATH AND DIFFERENTIATION. 1636-1644. 2010
- Inhibition of cAMP response element binding protein reduces neuronal excitability and plasticity, and triggers neurodegeneration. CEREBRAL CORTEX. 2535-2547. 2009
- Kinase networks integrate profiles of NMDA receptor mediated gene expression in hippocampus. JOURNAL OF BIOLOGICAL CHEMISTRY. 34101-34107. 2008
- Activation and blockade of choline of bovine alpha7 and alpha3beta4 nicotinic receptors expressed in oocytes. EUROPEAN JOURNAL OF PHARMACOLOGY. 53-60. 2006
- The Cysteine-rich with EGF-like domains 2 (CRELD2) protein interacts with the large cytoplasmic domain of human neuronal nicotinic acetylcholine receptor alpha4 and beta2 subunits. JOURNAL OF NEUROCHEMISTRY. 1585-1596. 2005
- Potentiation of human alpha4beta2 neuronal nicotinic receptors by a Flustra foliacea metabolite. NEUROSCIENCE LETTERS. 144-149. 2005
- Transcriptional regulation by activation and repression elements located at the 5'-non coding region of the human alpha9 nicotinic receptor subunit gene. JOURNAL OF BIOLOGICAL CHEMISTRY. 37249-37255. 2003
- A single neuronal nicotinic receptor alpha3alpha7beta4 is present in the bovine chromaffin cell.. ANNALS OF THE NEW YORK ACADEMY OF SCIENCES. 165-167. 2002
- Effects of benzothiazepines on human neuronal nicotinic acetylcholine receptors expressed in Xenopus oocytes.. BRITISH JOURNAL OF PHARMACOLOGY. 183-192. 2002
- Effects of gingenoside Rg2 on human neuronal nicotinic acetylcholine receptors.. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS. 1052-1059. 2002
- Effects of ginsenosides, active components of ginseng, on nicotinic acetylcholine receptors expressed in Xenopus oocytes.. EUROPEAN JOURNAL OF PHARMACOLOGY. 37-45. 2002
- Role of the large cytoplasmic loop of the alpha7 neuronal nicotinic acetylcholine receptor subunit in receptor expression and function.. BIOCHEMISTRY. 7931-7938. 2002
- Transcription factors NF-Y and Sp-1 are important determinants of the promoter activity of the bovine and human neuronal nicotinic receptor beta4 subunit genes.. JOURNAL OF BIOLOGICAL CHEMISTRY. 8866-8876. 2002
- Activity of the nicotinic acetylcholine receptor alpha5 and alpha7 subunit promoters in muscle cells.. DNA AND CELL BIOLOGY. 657-666. 2001
- Multiple functional Sp1 domains in the minimal promoter region of the neuronal nicotinic alpha5 subunit gene. JOURNAL OF BIOLOGICAL CHEMISTRY. 4693-4701. 1999
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chapter
- Epigenetic factors in intellectual disability: The Rubinstein¿Taybi syndrome as a paradigm of neurodevelopmental disorder with epigenetic origin. Epigenetics and Neuroplasticity - Evidence and Debate. 139-176. 2014
- Choline as a tool to evaluate nicotinicreceptor function in chromaffin cells.. CELL BIOLOGY OF THE CHROMAFFIN CELL. 255-259. 2004
- Does an homomeric alpha7 nicotinicreceptor exist in bovine chromaffincells?. CELL BIOLOGY OF THE CHROMAFFIN CELL. 251-254. 2004
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congress communication
- The neuroinflammatory component of Huntington's disease is present in the retina of mouse models 2023
- A GENOME-WIDE PERSPECTIVE OF EPIGENETICS IN HUNTINGTON¿S DISEASE 2014
- Defining the role of CREB-binding protein in histone acetylation, gene expression and neurodegeneration 2012
- Genomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington¿s disease 2012
- Role of CREB-binding protein and histone acetylation in neuronal plasticity 2012
- Transcriptional dysregulation and histone acetylation analysis in Huntington¿s disease models 2012
- CBP is required for environmental enrichment-induced neurogenesis and cognitive enhancement 2011
- Caracterización de las funciones de la proteína CBP (CREB-binding protein) en neuronas excitatorias 2011
- Decoding transcriptional networks in activity-dependent gene expression: a comparative genomics study of CREB, SRF, EGR1 and FOS regulons 2011
- Determining the roles of CBP in forebrain principal neurons 2011
- A genome-wide approach for unveiling neuronal activity-driven transcriptomes 2010
- A genome-wide approach for unveiling plasticity-related transcriptomes 2010
- Transcriptional control of neural plasticity and mental retardation: the CREB-binding protein 2010
- Two much and too few: unbalanced CREB activity leads to different forms of neurodegeneration 2010
- Definiendo el transcriptoma neuronal dependiente de actividad 2009
- Differential contribution of synaptic plasticity-related transcription factors to the activity-driven neuronal transcriptome 2009
- An homomeric alpha7 nicotinic receptor does not exist in bovine chromaffin cells 2006
- Determination of synaptogenesis factors using integrated global technologies 2006
- Role of the neuronal network activity on the gene expression profile in hippocampal cultures 2006
- Profiling of synapse proteome function using transcriptome and electrophysiological microarrays on primary hippocampus neurons 2005
- Profiling of synapse proteome function using transcriptome and electrophysiological microarrays on primary hippocampal neurons 2005
- Profiling of synapse proteome function using transcriptome and electrophysiological microarrays on primary hippocampal neurons 2005
- A complex alfa3alfa7beta4 nicotinic receptor might be expressed in the bovine chromaffin cell. 2003
- Aislamiento de tres nuevas proteínas que se asocian específicamente con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal 2003
- Dual effects of choline on nicotinic receptors of bovine chromaffin cells. 2003
- Effects of an alkaloid from Flustra foliacea on recombinant human neuronal nicotinic acetylcholine receptors. 272-272. 2003
- Estudio de la potenciación de los receptores nicotínicos de acetilcolina neuronales humanos alfa4beta2 mediante un metabolito de la Flustra foliacea 2003
- Trap: una nueva proteína que interacciona con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal 2003
- Identificación y caracterización de proteínas que interaccionan con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal 2002
- Caracterización de los efectos de nuevos agonistas nicotínicos en la célula cromafín bovina. 2002
- Efecto de los alcaloides de Flustra Foliacea en receptores nicotínicos neuronales humanos recombinantes. 2002
- Efecto dual de colina sobre las respuestas nicotínicas en la célula cromafín bovina. 2002
- Expresión funcional de receptores nicotínicos de acetilcolina: papel de la principal región citoplásmica de la subunidad alfa7 2002
- Identificación y caracterización de proteínas que interaccionan con el lazo citoplásmico de la subunidad alfa4 del receptor nicotínico neuronal. 2002
- Transcriptional regulatory elements of the neuronal nicotinic receptor alpha9 subunit. 3rd Forum of European Neuroscience 2002
- ¡Un solo receptor nicotínico en la célula cromafín! 2002
- A single neuronal nicotinic receptor alpha3alpha5alpha7beta4 is present in bovine chromaffin cell. Pharmacological evidence. 2001
- Efectos del ginsenósido Rg2 sobre receptores nicotínicos neuronales humanos recombinantes. 2001
- Regulación basal del promotor de la subunidad beta4 humana del receptor nicotínico neuronal. 669-670. 2001
- Un único receptor nicotínico neuronal alfa3alfa5alfa7beta4 está presente en la célula cromafín bovina. Evidencia farmacológica . 886-887. 2001
- ¿Un sólo receptor nicotínico en la célula cromafín? 2001
- Papel de la gran región citoplásmica de la subunidad alfa7 en la expresión funcional de receptores nicotínicos de acetilcolina 2000
- Interacciones de la nicotina y derivados del diltiazem en receptores nicotínicos neuronales humanos 2000
- Múltiples sitios de Sp1 en el promotor de la subunidad alfa5 del receptor nicotínico neuronal de acetilcolina 2000
- Regulación del promotor de la subunidad beta4 bovina del receptor nicotínico neuronal por los factores NF-Y y Sp1. 238-238. 1999
- Activación de los promotores de las subunidades alfa5 y alfa7 de los receptores nicotínicos neuronales de acetilcolina en células musculares . 268-268. 1999
- Activación y modulación de receptores nicotínicos neuronales. 204-204. 1999
presentations
-
invited conference
- Genomic landscape of transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington¿s disease, Conferencia 2012
- Transcriptional and epigenetic dysregulation in a mouse model of early onset Huntington¿s disease, Conferencia 2012
- Transcriptome and electrophysiological profiling of hippocampal neuronal cultures, Conferencia 2005
Research
investigator on
- SAF2014-56197-R 2015 - 2017
Teaching
teaching activities
- BIOQUÍMICA (Grado en Biotecnología) - Prácticas en Aula de Informática Teacher 2022 - 2024
- BIOQUÍMICA DE ALIMENTOS (Grado en Ciencia y Tecnología de los Alimentos) - Prácticas de Laboratorio Húmedo Teacher 2022 - 2024
- BIOQUÍMICA DE ALIMENTOS (Grado en Ciencia y Tecnología de los Alimentos. Plan 2020) - Prácticas de Laboratorio Húmedo Teacher 2022 - 2024
- ESTRUCTURA Y FUNCIÓN DE LAS PROTEÍNAS (Grado en Biotecnología) - Prácticas en Aula de Informática Teacher 2022 - 2024
- NUEVAS TERAPIAS (Máster Universitario en Neurociencia: de la Investigación a la Clínica) - Clase Magistral Teacher 2021 - 2024
- BIOQUÍMICA (Grado en Ciencias Ambientales) - Prácticas de Laboratorio Húmedo Teacher 2022 - 2023
- BIOQUÍMICA (Grado en Ciencias Ambientales) - Prácticas en Aula de Informática Teacher 2022 - 2023
- NEUROPATOLOGÍA (Máster Universitario en Neurociencia: de la Investigación a la Clínica) - Clase Magistral Teacher 2012 - 2016
Contact
full name
- LUIS MIGUEL VALOR BECERRA