Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

VIANA DE LA IGLESIA, FELIX

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Positions

CIENTIFICO TITULAR CSIC, Instituto de Neurociencias 2003 -
GRUPO 2: BECAS A TITULADOS DE GRADO MEDIO Y SUPERIOR, Fisiología 1999

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supported publications or other works

BIOGENESIS, TRAFICO Y MODULACION DE LA FUNCION DEL CANAL IONICO TERMOSENSIBLE TRPM8 2010
BIOPHYSICAL AND PHARMACOLOGICAL CHARACTERIZATION OF NOVEL TRPM8 CHANNEL MODULAR¿¿ 2024
CARACTERIZACION DEL CANAL IONICO TRPM8 EN CELULAS DE CANCER DE PROSTATA Y SU IMPLICACION EN LA PROLIFERACION TUMORAL 2008
CARACTERIZACIÓN DE LÍNEAS TRANSGÉNICAS MURINAS PARA EL CANAL IÓNICO TERMOSENSIBLE TRPM8:VALORACIÓN FUNCIONAL, EXPRESIÓN EXTRAGANGLIONAR E IDENTIFICACIÓN DE NUEVAS DIANAS DE INERVACIÓN 2020
COLD-SENSITIVE FIBERS OF THE MOUSE TONGUE: MOLECULAR AND FUNCTIONAL TYPES AND MODULATORY ROLE ON DRINKING BEHAVIOR 2014
Caracterización de líneas transgénicas murinas para el canal iónico termosensible TRPM8: valoración funcional, expresión extraganglionar e identificación de nuevas dianas de inervación. 2019
Disección de los circuitos espinales subyacentes al dolor inflamatorio: conectividad neuronal y participación del canal iónico TRPA1 2024
FISIOPATOLOGIA DEL CANAL IONICO TRPA1 EN EL AGRANDAMIENTO GINGIVAL Y EN LA NEUROPATIA INDUCIDA POR OXALIPLATINO 2013
HE COLD-ACTIVATED TRPM8 CHANNEL: AGONISM BY MACROLIDE IMMUNOSUPPRESSANTS AND MODULATION BY GQ PROTEIN-COUPLED RECEPTORS SIGNALING PATHWAYS 2019
LOS CANALES IÓNICOS TERMOSENSIBLES TRPM8 Y TRPA1: PAPEL EN LA TERMOSENSACIÓN Y LA TERMORREGULACIÓN EN CONDICIONES FISIOLÓGICAS Y EN UN MODELO EXPERIMENTAL DE NEUROPATÍA INDUCIDA POR EL OXALIPLATINO 2015
MECHANISMS OF COLD SENSITIVITY IN MOUSE VAGAL AND TRIGEMINAL GANGLION NEURONS: FUNCTIONAL AND MOLECULAR CHARACTERIZATION IN HEALTHY AND NEUROPATHIC CONDITIONS 2020
Modulación del canal iónico TRPA1 por la chaperona sigma 1: papel en la neuropatía periférica inducida por oxaliplatino 2020
PARTICIPACIÓN DEL CANAL IÓNICO DE POTASIO TASK-3 EN LA SENSIBILIDAD A FRÍO: ESTUDIO DE SU EXPRESIÓN Y FUNCIÓN EN NEURONAS SENSORIALES PRIMARIAS QUE EXPRESAN EL CANAL IÓNICO TRPM8 2014
PHARMACOLOGICAL MODULATION OF THE NATIVE AND RECOMBINANT THERMOSENSITIVE ION CHANNEL TRANSIENT RECEPTOR POTENTIAL MELASTATIN 8 2014
PROPIEDADES BIOFISICAS Y FARMACOLOGIA DE LOS CANALES IONICOS TRP SENSIBLES A TEMPERATURA: TRPV1, TRPA1 YTRPM8 2009
TRANSCRIPTOMA DE LAS NEURONAS TERMOSENSIBLES: CARACTERIZACIÓN MOLECULAR Y FUNCIONAL EN CONDICIONES FISIOLÓGICAS Y EN LA NEUROPATÍA PERIFÉRICA INDUCIDA POR EL AGENTE QUIMIOTERAPEÚTICO OXALIPLATINO 2022
TRANSDUCCION DEL FRIO EN NEURONAS SENSORIALES DEL VAGO 2009
The cold-activated TRPM8 channel: agonism by macrolide immunosuppressants and modulation by Gq protein-coupled receptors signaling pathways 2018

selected publications

academic article
- Piezo2 channels and tactile pain: an intriguing voltage connection. BRAIN. 1-3. 2024
- The ion channel TRPM8 is a direct target of theimmunosuppressant rapamycin in primary sensory neurons. BRITISH JOURNAL OF PHARMACOLOGY. 3192-3214. 2024
- The cold sensing ion channel TRPM8 regulates central and perpheral clockwork and the circadian oscillations of body temperature. ACTA PHYSIOLOGICA. 1-21. 2023
- TRPA1 modulation by Sigma-1 receptor prevents oxaliplatin-induced painful peripheral neuropathy. BRAIN. 1-56. 2022
- The cold-sensing ion channel TRPM8 regulates central and peripheral clockwork and the circadian oscillations of body temperature. ACTA PHYSIOLOGICA. 2022
- Validation of Six Commercial Antibodies for the Detection of Heterologous and Endogenous TRPM8 Ion Channel Expression. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1-19. 2022
- Constitutive phosphorylation as a key regulator of TRPM8 channel function. JOURNAL OF NEUROSCIENCE. 8475-8493. 2021
- Piezo2 mediates low-threshold mechanically-evoked pain in the cornea. JOURNAL OF NEUROSCIENCE. 8976-8993. 2020
- Expression of the cold thermoreceptor TRPM8 in rodent brain thermoregulatory circuits. JOURNAL OF COMPARATIVE NEUROLOGY. 1-23. 2019
- The immunosuppressant macrolide tacrolimus activates cold-sensing TRPM8 channels.. JOURNAL OF NEUROSCIENCE. 949-969. 2019
- Morphological and functional changes in TRPM8-expressing corneal cold thermoreceptor neurons during aging and their impact on tearing in mice.. JOURNAL OF COMPARATIVE NEUROLOGY. 1859-1874. 2018
- New Insight in Cold Pain: Role of Ion Channels, Modulation, and Clinical Perspectives. JOURNAL OF NEUROSCIENCE. 11435-11439. 2016
- TRPA1 channels: molecular sentinels of cellular stress and tissue damage. JOURNAL OF PHYSIOLOGY-LONDON. 4151-4169. 2016
- TRPA1 channels mediate acute neurogenic inflammation and pain produced by bacterial endotoxins.. NATURE COMMUNICATIONS. 1-14. 2014
- N-glycosylation of TRPM8 ion channels modulates temperature sensitivity of cold thermoreceptor neurons.. JOURNAL OF BIOLOGICAL CHEMISTRY. 18218-18229. 2012
- Role of Ih in the Firing Pattern of Mammalian Cold Thermoreceptor Endings. JOURNAL OF NEUROPHYSIOLOGY. 2012
- The Influence of Cold Temperature on Cellular Excitability of Hippocampal Networks. PLOS ONE. 52475-52483. 2012
- Membrane-tethered peptides patterned after the TRP domain (TRPducins) potently and selectively inhibit TRPV1 channel activity. . FASEB J. 1628-1640. 2011
- Pharmacologycal and functional proporties of TRPM8 channels in prostate tumor cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 99-114. 2011
- Ocular surface wetness is regulated by TRPM8-dependent cold thermoreceptors of the cornea.. NATURE MEDICINE. 1396-1399. 2010
- Pharmacological and functional properties of TRPM8 channels in prostate tumor cells. PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY. 2010
- Characteristics and physiological role of hyperpolarization activated currents in mouse cold thermoreceptors.. JOURNAL OF PHYSIOLOGY-LONDON. 1961-1976. 2009
- Converting cold into pain.. EXPERIMENTAL BRAIN RESEARCH. 13-30. 2009
- Differential role of the menthol-binding residue Y745 in the antagonism of thermally gated TRPM8 channels.. MOLECULAR PAIN. 62-75. 2009
- Lipid raft segregation modulates TRPM8 channel activity. JOURNAL OF BIOLOGICAL CHEMISTRY. 9215-9224. 2009
- Nicotine activates the chemosensory cation channel TRPA1.. NATURE NEUROSCIENCE. 1293-1299. 2009
- TRPA1 modulators in preclinical development. EXPERT OPINION ON THERAPEUTIC PATENTS. 1787-1799. 2009
- Understanding the mechanisms of cold-evoked pain in humans. PAIN. 7-8. 2009
- Variable threshold of trigeminal cold-thermosensitive neurons is determined by a balance between TRPM8 and Kv1 potassium channels.. JOURNAL OF NEUROSCIENCE. 3120-3131. 2009
- Funny currents are becoming serious players in nociceptor¿s sensitization. JOURNAL OF PHYSIOLOGY-LONDON. 5841-5842. 2008
- Hypoosmotic- and pressure-induced membrane stretch activate TRPC5 channels. JOURNAL OF PHYSIOLOGY-LONDON. 5633-5649. 2008
- Identification of molecular determinants of channel gating in the transient receptor potential box of vanilloid receptor I. FASEB J. 3298-3306. 2008
- Molecular and cellular limits to somatosensory specificity. MOLECULAR PAIN. 1-17. 2008
- Potassium channels shape and brake primary sensory neuron excitability. JOURNAL OF PHYSIOLOGY-LONDON. 5039-5040. 2008
- TRPA1 channels mediate noxious cold sensing in mammalian vagal sensory neurons.. JOURNAL OF NEUROSCIENCE. 7863-7875. 2008
- TRPA1 channels. Novel targets of 1,4-dihydropyridines. CHANNELS. 1-10. 2008
- Transient receptor potential channels in sensory neurons as novel targets of the antimycotic agent clotrimazole.. JOURNAL OF NEUROSCIENCE. 576-586. 2008
- A Role of the Transient Receptor Potential Domain of Vanilloid Receptor I in Channel Gating. JOURNAL OF NEUROSCIENCE. 11641-11650. 2007
- Bidirectional shifts of TRPM8 channel gating by temperature and chemical agents modulate the cold sensitivity of mammalian thermoreceptors. JOURNAL OF PHYSIOLOGY-LONDON. 155-174. 2007
- Comparative effects of the non-steroidal antiinflammatory drug Nepafenac on corneal sensory nerve fibers responding to chemical irritation. INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE. 182-188. 2007
- Contribution of sensory fibers of the cornea to eye dryness sensations. SOCIETY FOR NEUROSCIENCE ABSTRACTS. 2007
- Transcriptional control of cholesterol biosynthesis in Schwann cells by axonal neuregulin 1. JOURNAL OF BIOLOGICAL CHEMISTRY. 28768-28778. 2007
- Transduction in cold receptors. PHYSIOLOGICAL RESEARCH. 2007
- Transduction molecules in nociception (Review). JOURNAL OF PHYSIOLOGY-LONDON. 2007
- Cold sensitivity in axotomized fibers of experimental neuromas in mice. PAIN. 24-35. 2006
- Contribution of TRPM8 channels to cold tranduction in primary sensory neurons and peripheral nerve terminals. JOURNAL OF NEUROSCIENCE. 12512-12525. 2006
- Inhibition of a background potassium channel by Gq-protein alpha-subunits. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 3422-3427. 2006
- Activation by heat an capsaicin of peripheral nerve endings and soma of cold primary sensory neurons. JOURNAL OF NEUROSCIENCE. 1-1. 2005
- The contribution of TRPM8 channels to cold sensing in mammalian neurones. . JOURNAL OF PHYSIOLOGY-LONDON. 415-426. 2005
- Bases celulares y moleculares de la transducción de estímulos térmicos en mamíferos. REVISTA DE NEUROLOGIA. 1117-1191. 2003
- Cold and mentol responses in trigeminal sensory neurons and trpm8-transfected cells. SOCIETY FOR NEUROSCIENCE ABSTRACTS. 585-585. 2003
- GAP43 is an osmotic-dependent activator of inositol triphosphate-mediated Ca2+-release. EMBO JOURNAL. 3004-3014. 2003
- Attenuation of Chemical and Thermal Nociception and Hyperalgesia by Novel VR1 Blockers.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. 2374-2379. 2002
- Attenuation of chemical and thermal nociception and hyperalgesia by novel VR1 blockers.. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME. 2374-2379. 2002
- Postnatal changes in membrane properties of mice trigeminal ganglion neurons.. JOURNAL OF NEUROPHYSIOLOGY. 2398-2407. 2002
- Specificity of cold thermotransduction is determined by differential ionic channel expression.. NATURE NEUROSCIENCE. 254-260. 2002
- Differential expression of ionic channels in cold-sensitive and cold-insensitive mammalian primary sensory neurons.. SOCIETY FOR NEUROSCIENCE ABSTRACTS. 2001
- Modulación de la transducción mecano-nociceptiva por sustancias viscoelásticas.. REV. NEUROL.. 660-660. 2001
- Role of K+ channels in the transduction of cold temperatures by mammalian primary sensory neurons.. SOCIETY FOR NEUROSCIENCE ABSTRACTS. 2001
- Swelling-activated calcium signaling in cultured mouse primary sensory neurons.. EUROPEAN JOURNAL NEUROSCIENCE. 1-16. 2001
chapter
- TRPM8. Handbook of Experimental Pharmacology . Volume 222 2014. Mammalian Transient Receptor Potential (TRP) Cation Channels. 547-579. 2014
- Nociceptor, cold thermotransduction. Encyclopedia of Pain. Mechanonociceptors. 2268-2274. 2013
- Nociceptors, cold Thermotransduction. Encyclopedia of Pain. 1413-1417. 2007
- Transduction and encoding of noxious stimuli. Ecyclopedia of Pain. 2515-2529. 2007
congress communication
patent

presentations

invited conference
- Pathophysiology of TRPA1 Channels: Role in Neuropathic and Inflammatory Pai, Conferencia 2022
- Los Premios Nobel de Fisiología o Medicina: 115 años de un viaje sensacional, Conferencia 2022
- Neuroprotection of chemotherapy-induced peripheral neuropathy by Sigma1 receptor antagonists: role of TRPA1 channels, Conferencia 2022
- Papel de los canales iónicos TRP en la transducción de estímulos térmicos y nociceptivos, Conferencia 2009
- Calcio y transducción sensorial, Conferencia
- Feeling cool: cellular mechanisms of cold temperature transduction in sensory neurons, Conferencia
- Mecanismos celulares de la transducción del frío en neuronas sensoriales, Conferencia
- Multiples roles of potassium channels in the transduction properties of vertebrate thermoreceptors, Conferencia
- Propiedades eléctricas de las células nerviosas, Conferencia
- Transducción sensorial: Neuromodulación, Conferencia
- Transduction mechanisms of mechanical stimuli in sensory neurones, Conferencia