selected publications
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academic article
- 1¿(2¿,5¿-Dihydroxyphenyl)-3-(2-fluoro-4-hydroxyphenyl)-1- propanone (RGM079): A Positive Allosteric Modulator of ¿7 Nicotinic Receptors with Analgesic and Neuroprotective Activity. ACS CHEMICAL NEUROSCIENCE. 3900-3909. 2019
- Amino acid and peptide prodrugs of diphenylpropanones positive allosteric modulators of ¿7 nicotinic receptors with analgesic activity.. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 157-165. 2018
- 1,3-diphenylpropan-1-ones as allosteric modulators of alpha7 nACh receptors with analgesic and antioxidant properties. FUTURE MEDICINAL CHEMISTRY. 731-749. 2016
- New transient receptor potential TRPV1, TRPM8 and TRPA1 channel antagonists from a single linear ß,¿-diamino ester scaffold. RSC ADVANCES. 6868-6877. 2016
- Tryptamine-based derivatives as Transient Receptor Potential Melastatin type-8 (TRPM8) channel modulators. JOURNAL OF MEDICINAL CHEMISTRY. 2179-2191. 2016
- Adamantyl Analogues of Acetaminophen as Potent Analgesic Drugs. PLOS ONE. 1-9. 2014
- De Novo Designed Library of Linear Helical Peptides: An Exploratory Tool in the Discovery of Protein-Protein Interaction Modulators.. ACS COMBINATORIAL SCIENCE. 250-258. 2014
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congress communication
- Discovery of a new class of TRPV1 open channel blockers (OCBS): design, synthesis, evaluation and structure activity relationship data 2015
- NEW TRPM8 ANTAGONISTS FROM HETEROCYCLIC LIBRARIES 2015
- NEW TRPM8 ANTAGONISTS FROM HETEROCYCLIC LIBRARIES 2015
- New allosteric modulators of ¿7 nicotinic receptors with analgesic and antioxidant properties 2015
- Pro-drug Approaches to New Allosteric Modulators of ¿7 nAChRs with Analgesic Activity 2015
- Discovery of a new class of TRPV1 Open Channel Blockers (OCBs): Design, Synthesis, Evaluation and SAR data. 15th world congress of pain 2014
- Highly functionalized ß,¿-diamino esters: New TRPV1, TRPM8 and TRPA1 antagonists from a single linear scaffold. 2014
- Discovery of New Antagonists for TRPM8 Channel by High Throughput Assay. 2013
- A family of compounds with a common central scaffold renders modulators for TRPV1, TRPM8 and TRPA1 channels 2012
- Discovery of new hits for TRPV1 blockade by High throughput assays. 2012
- Diversity-oriented synthesis from amino acid-derived b-Ketoesters: Finding new TRPV1 antagonist 2011
- From amino acid-derived ß-ketoesters to innovative compounds. Synthetic aspects and discovery of new ion channel modulators 2011
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patent
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thesis