Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

GONZALEZ ALVAREZ, MARTA

Person (Active)

Positions

Profesor/a Titular Universidad, Ingeniería 2017 -
MIEMBRO, Optimización Biofarmacéutica y disolución biopredictiva 2009 -
Profesor/a Contratado/a Doctor/a, Ingeniería 2009 - 2017

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supported publications or other works

selected publications

academic article
- Access to the CNS: Strategies to overcome the BBB. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2023
- Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood-Brain Barrier in Patients with Glioblastoma.. PHARMACEUTICS. 1430-1442. 2023
- Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain. NANOMEDICINE. 1799-1813. 2023
- Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients. PHARMACEUTICS. 2565-2577. 2022
- Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development. PHARMACEUTICS. 182-197. 2022
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 121415-121426. 2022
- Polymer Based Gels: Recent and Future Applications in Drug Delivery Field. CURRENT DRUG DELIVERY. 1-15. 2022
- Radiolabeled Trastuzumab Solid Lipid Nanoparticles for Breast Cancer Cell: in Vitro and in Vivo Studies. ACS OMEGA. 30015-30027. 2022
- Ventajas del uso de la iontoforesis para la administración transdérmica de analgésicos. ACTUALIDAD EN FARMACOLOGIA Y TERAPEUTICA. 114-131. 2022
- An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products. PHARMACEUTICS. 507-519. 2021
- Controlled delivery formulations. PHARMACEUTICS. 374-377. 2021
- Formulaciones para la cicatrización de heridas, presente y futuro.. REVISTA ESPAÑOLA DE CIENCIAS FARMACEUTICAS. 1-12. 2021
- In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 120-126. 2021
- Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study. PHARMACEUTICS. 982-1009. 2021
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2021
- New In Vitro Methodology for Kinetics Distribution Prediction in the Brain. An Additional Step towards an Animal-Free Approach. ANIMALS. 3521-3536. 2021
- Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat.. PHARMACEUTICS. 1402. 2021
- pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis.. PHARMACEUTICS. 94. 2021
- Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019. PHARMACEUTICS. 316-330. 2020
- Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool. PHARMACEUTICS. 633. 2020
- Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats. MOLECULAR PHARMACEUTICS. 2310-2318. 2020
- Effect of excipients on oral absorption process according to the different gastrointestinal segments. EXPERT OPINION ON DRUG DELIVERY. 1-20. 2020
- Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 168-176. 2020
- New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 6502. 2020
- Oral controlled release dosage forms: dissolution versus diffusion. EXPERT OPINION ON DRUG DELIVERY. 791-803. 2020
- Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery. NANOMATERIALS. 1290-1308. 2020
- Two-step in vitro-in vivo correlations: Deconvolution and convolution methods, which one gives the best predictability? Comparison with one-step approach. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 185-197. 2020
- Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System. PHARMACEUTICS. 567-583. 2019
- Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 174-183. 2019
- Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease.. MOLECULAR PHARMACEUTICS. 2418-2429. 2019
- Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 154-161. 2019
- Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products.. PHARMACEUTICS. 663-673. 2019
- Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 36-42. 2019
- Structural basis and effect of copper(II) complexes with 4-oxo-thiazolidine ligands on DNA binding and nuclease activity. JOURNAL OF INORGANIC BIOCHEMISTRY. 2019
- Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2231-2241. 2018
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.. PHARMACEUTICAL RESEARCH. 1-12. 2018
- Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 148-157. 2018
- Functional Magnetic Mesoporous Silica Microparticles Capped with an Azo-Derivative: A Promising Colon Drug Delivery Device. MOLECULES. 375-388. 2018
- Giardiasis: Characteristics, Pathogenesis and New Insights About Treatment. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 1287-1303. 2018
- In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC. MOLECULAR PHARMACEUTICS. 2307-2315. 2018
- Ionic hydrogel based on chitosan crosslinked with 6-Phosphogluconic Trisodium salt. BIOMACROMOLECULES. 1294-1304. 2018
- Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs.. PHARMACEUTICS. 213-228. 2018
- Preclinical models for colonic absorption, application to controlled release formulation development.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 247-259. 2018
- Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment. JOURNAL OF CONTROLLED RELEASE. 58-69. 2018
- Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 191-196. 2017
- Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue.. MOLECULAR PHARMACEUTICS. 2017
- Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 135-141. 2017
- PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2017
- Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture.. MOLECULAR PHARMACEUTICS. 1264-1270. 2017
- Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 334-340. 2016
- Enhancing Oral Absorption of ß-Lapachone: Progress Till Date.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-9. 2016
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 795-806. 2016
- Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 201-208. 2016
- . In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model . JOURNAL OF PHARMACEUTICAL SCIENCES. 3136-3145. 2015
- Cyclometalated Iminophosphorane Gold(III) and Platinum(II). JOURNAL OF MEDICINAL CHEMISTRY. 5825-5841. 2015
- Drug gastrointestinal absorption in rat: strain and gender differences. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 198-203. 2015
- In-situ intestinal rat perfusions for human F-abs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 1-7. 2015
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-12. 2015
- Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I. MOLECULAR PHARMACEUTICS. 3167-3174. 2015
- A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 366-373. 2014
- Modified Non-Sink Equation for Permeability Estimation in Cell Monolayers: Comparison with Standard Methods . MOLECULAR PHARMACEUTICS. 1403-1414. 2014
- Validation of phenol red versus gravimetric method for water reabsorption correction and study of gender differences in Doluisio's absorption technique. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 105-110. 2014
- Variability of Permeability Estimation from Different Protocols of Subculture and Transport Experiments in Cell Monolayers.. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS . 1-11. 2014
- Hydrogels: an interesting strategy for smart drug delivery.. THERAPEUTIC DELIVERY. 157-160. 2013
- Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier . MOLECULAR PHARMACEUTICS. 3822-3831. 2013
- Mixed-ligand copper(II)-sulfonamide complexes: effect of the sulfonamide derivative on DNA binding, DNA cleavage, genotoxicity and anticancer activity.. DALTON TRANSACTIONS. 10244-10259. 2013
- Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecin Derivatives. ACS MEDICINAL CHEMISTRY LETTERS. 86-90. 2013
- Nuclease activity and ultrastructural effects of new sulfonamides with anti-leishmanial and trypanocidal activities. PARASITOLOGY INTERNATIONAL. 604-613. 2012
- SPR in oral bioavailability: specificity or integrality?. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 534-550. 2012
- Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 290-291. 2011
- Biological assays and noncovalent interactions. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 515-532. 2010
- Drug penetration across the blood¿brain barrier: an overview. THERAPEUTIC DELIVERY. 535-562. 2010
- (1,3,4-Oxadiazole)copper(II) Compounds: Dimensionality, Magnetism and. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 373-388. 2009
- In vivo and in vitro anti-leishmanial activities of 4-nitro-N-pyrimidin- and N-pyrazin-2-ylbenzenesulfonamides, and N2-(4-nitrophenyl)-N1-propylglycinamide. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 7449-7456. 2009
- Oxidative nuclease activity of ferromagnetically coupled. JOURNAL OF INORGANIC BIOCHEMISTRY. 243-255. 2009
- Synthesis and copper-mediated nuclease activity of a tetracationic tris(2,2'-bipyridine) ligand.. JOURNAL OF INORGANIC BIOCHEMISTRY. 1067-1073. 2009
- Synthesis, structure and biological properties of several binary and ternary. POLYHEDRON. 138-144. 2009
- Toward the development of metal-based synthetic nucleases: DNA binding and oxidative DNA cleavage of a mixed copper(II) complex with N-(9H-purin-6-yl)benzenesulfonamide and 1,10-phenantroline. Antitumor activity in human Caco-2 cells and Jurkat T lymphocytes. Evaluation of p53 and Bcl-2 proteins in the apoptotic mechanism.. JOURNAL OF INORGANIC BIOCHEMISTRY. 923-934. 2009
- Unique pharmacology of Kar-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 11-19. 2009
- Copper-mediated DNA Photocleavage by a Tetrapyridoacridine (tpac) ligand. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS. 3286-3290. 2008
- Evaluation of antiproliferative activities and apoptosis induction caused by copper(II)-benzothiazolesulfonamide complexes in jurkat T lymphocytes and Caco-2 cells. JOURNAL OF BIOLOGICAL INORGANIC CHEMISTRY. 1249-1265. 2008
- Structure, magnetic properties and nuclease activity of pyridine-2-carbaldehyde thiosemicarbazonecopper(II) complexes. JOURNAL OF INORGANIC BIOCHEMISTRY. 1910-1920. 2008
- A Dinuclear Copper(II) Complex with Adeninate Bridge Ligands and Prominent DNA Cleavage Activity. Structural and Spectroscopic. Characterization and Magnetic Properties. INORGANIC CHEMISTRY. 7178-7188. 2007
- Copper complexes with sulfonamides derivatives of natural maino acids as chemical nucleases. ZEITSCHRIFT FUR ANORGANISCHE UND ALLGEMEINE CHEMIE. 1937-1944. 2007
- Crystal structures and spectroscopic properties of copper(II)-bis(2-pyridylcarbonyl)amide-chlorobenzoate complexes. POLYHEDRON. 5009-5015. 2007
- DNA interaction of new Copper(II) Complexes with Sulfonamides as ligands. JOURNAL OF INORGANIC BIOCHEMISTRY. 444-451. 2007
- Efficient DNA cleavage induced by copper(II) complexes with 2,4,6-tris(2-pyridyl)-1,3,5 triazine hydrolytic derivatives in presence of reducing agents. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 822-834. 2007
- Synthesis, Structure and Nuclease Properties of several Binary and Ternary Complexes of Cooper(II) with norfloxacin and 1,10-phenanthroline.. JOURNAL OF INORGANIC BIOCHEMISTRY. 831-840. 2007
- Copper (II) Complexes with sulfonamides derived from 2-picolylamine and their use as chemical nucleases. INORGANICA CHIMICA ACTA. 1465-1472. 2006
- DNA cleavage reaction induced by dimeric copper(II) complexes of N-substituted thiazole sulfonamides. JOURNAL OF INORGANIC BIOCHEMISTRY. 70-79. 2006
- Genotoxic potential of benzothiazolesulfonamide copper(II) complexes on yeast cells transformed with yEGFP expression constructs containing the RAD54 or RNR2 promoter. EUROPEAN JOURNAL OF INORGANIC CHEMISTRY. 3823-3834. 2006
- Oxidative DNA Cleavage Induced by an Iron(III) Flavonoid Complex. Synthesis, Crystal Structure and Characterization of bis-3-Hydroxyflavonato, Chloro, Methanol Iron(III) Complex. JOURNAL OF INORGANIC BIOCHEMISTRY. 1208-1218. 2006
chapter
- In silico, in situ, in vitro and in vivo predictive methods for modelling formulation performance. From current to future trends in pharmaceutical technology. 67-117. 2023
- In vitro ¿ in vivo correlation: General Concepts, Development and Advanced Approaches . CorrelaÇao in vitro in vivo no desenvolvimento de Medicamentos. 1-32. 2023
- JORNADAS MULTIDISCIPLINARES EN CIENCIAS DE LA SALUD COMO HERRAMIENTA PARA IMPULSAR EL TRABAJO MULTIDISCIPLINAR. Avances en Educación Superior e Investigación Vol.2. 286-286. 2023
- Medicamentos genéricos ¿iguales a la marca de referencia?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 181-189. 2022
- Medicamentos vía oral: ¿con qué volumen de agua se deben administrar?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 247-256. 2022
- Nutracéuticos para cuidar la piel. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 115-128. 2022
- Seguridad en cosmética: cosmética natural e ingredientes controvertidos. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 129-140. 2022
- ¿Influyen los alimentos en el efecto de los medicamentos?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 257-270. 2022
- Absorción transdermica: Modelos in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 321-330. 2015
- Ajuste nolineal por mínimos cuadrados en Excel. Uso de herramienta Solver. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 539-567. 2015
- Cálculo depermeabilidad en rata: perfusión sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 499-504. 2015
- Cálculos de lapermeabilidad intestinal in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 482-489. 2015
- Cálculos depermeabilidad en células de Franz. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 490-496. 2015
- Estudios de permeabilidad en humanos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 241-265. 2015
- Fundamentoscientíficos del BCS y de la Bioequivalencia in vitro: Aspectos teóricos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 66-83. 2015
- Importance and applications of cell and tissue-based in vitro models for drug permeability screening in early stages of drug development. In:Concepts and models for drug permeability studies ¿ Cell and tissue-based in vitro culture models.. Woodhead Publishing Series in Biomedicine. 1-15. 2015
- Investigación animal para el desarrollo de nuevos fármacos: reducir, refinar o reemplazar.. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 166-182. 2015
- Perfusion in situ sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 349-359. 2015
- Permeabilidad en cultivos celulares. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 266-299. 2015
- Prediccion de la fraccion oral absorbida. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 45-65. 2015
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-26. 2012
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-25. 2011
- Caco-2 cells for studying Intestinal absorption mechanisims: comparison and correlation with rat model. Caco-2 cells and their uses. 129-163. 2011
- COMPUTER AIDED LEARNING IN BIOPHARMACY. International technology, education and development conference. 2923-2926. 2009
- EDUCATIONAL STRATEGIES FOR THE INCREASING OF CREATIVITY. International technology, education and development conference. 2134-2137. 2009
- KNOWLEDGE ABOUT EHEA OF THE UNIVERSITARY STUDENTS . ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5870-5873. 2009
- PROGRAM PROPOSAL FOR EARLY CONTACT OF PREGRADUATE STUDENTS WITH THE RESEARCH WORLD: OR HOW TO MAKE THE RIGHT DECISION AT THE RIGHT TIME. International technology, education and development conference. 4692-4696. 2009
- TEAMWORK IN LABORATORY PRACTICES. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5968-5971. 2009
congress communication

presentations

invited conference
- Avances científicos en cosmética, Conferencia 2023