Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

GONZALEZ ALVAREZ, MARIA ISABEL

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Positions

Profesor/a Titular Universidad, Ingeniería 2016 -
MIEMBRO, Optimización Biofarmacéutica y disolución biopredictiva 2009 -
Profesor/a Contratado/a Doctor/a, Ingeniería 2008 - 2016

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selected publications

academic article
- Advancing the Harmonization of Biopredictive Methodologies through the Product Quality Research Institute (PQRI) Consortium: Biopredictive Dissolution of Dipyridamole Tablets. MOLECULAR PHARMACEUTICS. 5315-5325. 2024
- In Vivo Predictive Dissolution and Biopharmaceutic-Based In Silico Model to Explain Bioequivalence Results of Valsartan, a Biopharmaceutics Classification System Class IV Drug. PHARMACEUTICS. 1-14. 2024
- New mathematical model from dynamic dissolution rate tests. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2024
- Pharmaceutical Compounding in Veterinary Medicine: Suspension of Itraconazole. PHARMACEUTICS. 1-13. 2024
- Access to the CNS: Strategies to overcome the BBB. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2023
- Establishment and Validation of a New Co-Culture for the Evaluation of the Permeability through the Blood-Brain Barrier in Patients with Glioblastoma.. PHARMACEUTICS. 1430-1442. 2023
- Harmonizing Biopredictive Methodologies Through the Product Quality Research Institute (PQRI) Part I: Biopredictive Dissolution of Ibuprofen and Dipyridamole Tablets. AAPS JOURNAL. 45-57. 2023
- Intranasal administration of molecular-gated mesoporous nanoparticles to increase ponatinib delivery to the brain. NANOMEDICINE. 1799-1813. 2023
- An Innovative Formulation Based on Nanostructured Lipid Carriers for Imatinib Delivery: Pre-Formulation, Cellular Uptake and Cytotoxicity Studies. NANOMATERIALS. 1-36. 2022
- Exploring a Bioequivalence Failure for Silodosin Products Due to Disintegrant Excipients. PHARMACEUTICS. 2565-2577. 2022
- Exploring the Predictive Power of the In Situ Perfusion Technique towards Drug Absorption: Theory, Practice, and Applications. MOLECULAR PHARMACEUTICS. 749-762. 2022
- Integration of In Silico, In Vitro and In Situ Tools for the Preformulation and Characterization of a Novel Cardio-Neuroprotective Compound during the Early Stages of Drug Development. PHARMACEUTICS. 182-197. 2022
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 121415-121426. 2022
- Polymer Based Gels: Recent and Future Applications in Drug Delivery Field. CURRENT DRUG DELIVERY. 1-15. 2022
- Radiolabeled Trastuzumab Solid Lipid Nanoparticles for Breast Cancer Cell: in Vitro and in Vivo Studies. ACS OMEGA. 30015-30027. 2022
- Ventajas del uso de la iontoforesis para la administración transdérmica de analgésicos. ACTUALIDAD EN FARMACOLOGIA Y TERAPEUTICA. 114-131. 2022
- A Differential Equation Based Modelling Approach to Predict Supersaturation and In Vivo Absorption from In Vitro Dissolution-Absorption System (idas2) Data. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 1-12. 2021
- An In Vivo Predictive Dissolution Methodology (iPD Methodology) with a BCS Class IIb Drug Can Predict the In Vivo Bioequivalence Results: Etoricoxib Products. PHARMACEUTICS. 507-519. 2021
- Eremantholide C from aerial parts of Lychnophora trichocarpha, as drug candidate: fraction absorbed prediction in humans and BCS permeability class determination. DARU-JOURNAL OF PHARMACEUTICAL SCIENCES. 195-203. 2021
- Formulaciones para la cicatrización de heridas, presente y futuro.. REVISTA ESPAÑOLA DE CIENCIAS FARMACEUTICAS. 1-12. 2021
- In vitro model for predicting the access and distribution of drugs in the brain using hCMEC/D3 cells.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 120-126. 2021
- Lactose-Gated Mesoporous Silica Particles for Intestinal Controlled Delivery of Essential Oil Components: An In Vitro and In Vivo Study. PHARMACEUTICS. 982-1009. 2021
- Level A IVIVC for immediate release tablets confirms in vivo predictive dissolution testing for ibuprofen. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 2021
- New In Vitro Methodology for Kinetics Distribution Prediction in the Brain. An Additional Step towards an Animal-Free Approach. ANIMALS. 3521-3536. 2021
- One and Two-Step In Vitro-In Vivo Correlations Based on USP IV Dynamic Dissolution Applied to Four Sodium Montelukast Products. PHARMACEUTICS. 690-709. 2021
- Physiologically Based Pharmacokinetic (PBPK) Modeling for Predicting Brain Levels of Drug in Rat.. PHARMACEUTICS. 1402. 2021
- Regional Intestinal Drug Absorption: Biopharmaceutics and Drug Formulation. PHARMACEUTICS. 1-5. 2021
- pH-Dependent Molecular Gate Mesoporous Microparticles for Biological Control of Giardia intestinalis.. PHARMACEUTICS. 94. 2021
- Availability of Authorizations from EMA and FDA for Age-Appropriate Medicines Contained in the WHO Essential Medicines List for Children 2019. PHARMACEUTICS. 316-330. 2020
- Biomimetic Artificial Membrane Permeability Assay over Franz Cell Apparatus Using BCS Model Drugs. PHARMACEUTICS. 988-1002. 2020
- Candesartan Cilexetil In Vitro-In Vivo Correlation: Predictive Dissolution as a Development Tool. PHARMACEUTICS. 633. 2020
- Effect of Common Excipients on Intestinal Drug Absorption in Wistar Rats. MOLECULAR PHARMACEUTICS. 2310-2318. 2020
- Effect of excipients on oral absorption process according to the different gastrointestinal segments. EXPERT OPINION ON DRUG DELIVERY. 1-20. 2020
- Effect of thickener on disintegration, dissolution and permeability of common drug products for elderly patients. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 168-176. 2020
- In vivo predictive dissolution (IPD) for Carbamazepine formulations: Additional evidence regarding the universal biopredictive dissolution medium. . PHARMACEUTICS. 558-579. 2020
- New Insights of Oral Colonic Drug Delivery Systems for Inflammatory Bowel Disease Therapy. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 6502. 2020
- Oral controlled release dosage forms: dissolution versus diffusion. EXPERT OPINION ON DRUG DELIVERY. 791-803. 2020
- Recent developments in cancer therapy and diagnosis. JOURNAL OF PHARMACEUTICAL INVESTIGATION. 349-361. 2020
- Segmental-Dependent Solubility and Permeability as Key Factors Guiding Controlled Release Drug Product Development. PHARMACEUTICS. 295. 2020
- Surfactant-Triggered Molecular Gate Tested on Different Mesoporous Silica Supports for Gastrointestinal Controlled Delivery. NANOMATERIALS. 1290-1308. 2020
- Two-step in vitro-in vivo correlations: Deconvolution and convolution methods, which one gives the best predictability? Comparison with one-step approach. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 185-197. 2020
- Classification of WHO Essential Oral Medicines for Children Applying a Provisional Pediatric Biopharmaceutics Classification System. PHARMACEUTICS. 567-583. 2019
- Covalently crosslinked organophosphorous derivatives-chitosan hydrogel as a drug delivery system for oral administration of camptothecin. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 174-183. 2019
- Double Drug Delivery Using Capped Mesoporous Silica Microparticles for the Effective Treatment of Inflammatory Bowel Disease.. MOLECULAR PHARMACEUTICS. 2418-2429. 2019
- Exploring Bioequivalence of Dexketoprofen Trometamol Drug Products with the Gastrointestinal Simulator (GIS) and Precipitation Pathways Analyses. PHARMACEUTICS. 122-140. 2019
- Impact on intestinal permeability of pediatric hyperosmolar formulations after dilution: Studies with rat perfusion method.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 154-161. 2019
- Intestinal Permeability Study of Clinically Relevant Formulations of Silibinin in Caco-2 Cell Monolayers.. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 1606-1616. 2019
- Investigation to Explain Bioequivalence Failure in Pravastatin Immediate-Release Products.. PHARMACEUTICS. 663-673. 2019
- Ion-pair approach coupled with nanoparticle formation to increase bioavailability of a low permeability charged drug. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 36-42. 2019
- Biopharmaceutical optimization in neglected diseases for paediatric patients by applying the provisional paediatric biopharmaceutical classification system. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY. 2231-2241. 2018
- Closed-Loop Doluisio (Colon, Small Intestine) and Single-Pass Intestinal Perfusion (Colon, Jejunum) in Rat-Biophysical Model and Predictions Based on Caco-2.. PHARMACEUTICAL RESEARCH. 1-12. 2018
- Determination of intestinal permeability using in situ perfusion model in rats: Challenges and advantages to BCS classification applied to digoxin.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 148-157. 2018
- Evaluation and optimized selection of supersaturating drug delivery systems of posaconazole (BCS class 2b) in the gastrointestinal simulator (GIS): An in vitro-in silico-in vivo approach.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 258-269. 2018
- Giardiasis: Characteristics, Pathogenesis and New Insights About Treatment. CURRENT TOPICS IN MEDICINAL CHEMISTRY. 1287-1303. 2018
- In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC. MOLECULAR PHARMACEUTICS. 2307-2315. 2018
- Ionic hydrogel based on chitosan crosslinked with 6-Phosphogluconic Trisodium salt. BIOMACROMOLECULES. 1294-1304. 2018
- Long-Circulating Hyaluronan-Based Nanohydrogels as Carriers of Hydrophobic Drugs.. PHARMACEUTICS. 213-228. 2018
- Preclinical models for colonic absorption, application to controlled release formulation development.. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 247-259. 2018
- Smart gated magnetic silica mesoporous particles for targeted colon drug delivery: New approaches for inflammatory bowel diseases treatment. JOURNAL OF CONTROLLED RELEASE. 58-69. 2018
- Comparison of segmental-dependent permeability in human and in situ perfusion model in rat.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 191-196. 2017
- Evaluation of the intestinal permeability of rosemary (Rosmarinus officinalis L.) extract polyphenols and terpenoids in Caco-2 cell monolayers. PLOS ONE. 17206-17207. 2017
- Gated Mesoporous Silica Nanocarriers for a "Two-Step" Targeted System to Colonic Tissue.. MOLECULAR PHARMACEUTICS. 2017
- Investigating drug absorption from the colon: Single-pass vs. Doluisio approaches to in-situ rat large-intestinal perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 135-141. 2017
- PLGA nanoparticles are effective to control the colonic release and absorption on ibuprofen.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2017
- Phenolic compounds in rosemary as potential source of bioactive compounds against colorectal cancer: In situ absorption and metabolism study. JOURNAL OF FUNCTIONAL FOODS. 202-210. 2017
- Usefulness of Caco-2/HT29-MTX and Caco-2/HT29-MTX/Raji B Coculture Models To Predict Intestinal and Colonic Permeability Compared to Caco-2 Monoculture.. MOLECULAR PHARMACEUTICS. 1264-1270. 2017
- Assessment of the Regulatory Methods for the Comparison of Highly Variable Dissolution Profiles. AAPS JOURNAL. 1550-1561. 2016
- Development of an ion-pair to improve the colon permeability of a low permeability drug: Atenolol. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 334-340. 2016
- Enhancing Oral Absorption of ß-Lapachone: Progress Till Date.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-9. 2016
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 795-806. 2016
- Population pharmacokinetic model of lithium and drug compliance assessment. EUROPEAN NEUROPSYCHOPHARMACOLOGY. 1868-1876. 2016
- Segmental-dependent permeability throughout the small intestine following oral drug administration: Single-pass vs. Doluisio approach to in-situ rat perfusion.. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 201-208. 2016
- . In Situ Perfusion Model in Rat Colon for Drug Absorption Studies: Comparison with Small Intestine and Caco-2 Cell Model . JOURNAL OF PHARMACEUTICAL SCIENCES. 3136-3145. 2015
- Cyclometalated Iminophosphorane Gold(III) and Platinum(II). JOURNAL OF MEDICINAL CHEMISTRY. 5825-5841. 2015
- Drug gastrointestinal absorption in rat: strain and gender differences. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 198-203. 2015
- Exploring different strategies for imbalanced ADME data problem: case study on Caco-2 permeability modeling. MOLECULAR DIVERSITY. 1-17. 2015
- In-situ intestinal rat perfusions for human F-abs prediction and BCS permeability class determination: Investigation of the single-pass vs. the Doluisio experimental approaches. INTERNATIONAL JOURNAL OF PHARMACEUTICS. 1-7. 2015
- Intestinal Permeability of ß-Lapachone and Its Cyclodextrin Complexes and Physical Mixtures.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-12. 2015
- Investigating the Discriminatory Power of BCS-Biowaiver in Vitro Methodology to Detect Bioavailability Differences between Immediate Release Products Containing a Class I. MOLECULAR PHARMACEUTICS. 3167-3174. 2015
- Permeability Study of Polyphenols Derived from a Phenolic-Enriched Hibiscus sabdariffa Extract by UHPLC-ESI-UHR-Qq-TOF-MS. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES. 18396-18411. 2015
- Semi-physiologic model validation and bioequivalence trials simulation to select the best analyte for acetylsalicylic acid. European journal of pharmaceutical sciences. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 86-94. 2015
- Validation of a semi-physiological model for caffeine in healthy subjects and cirrhotic patients.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 57-63. 2015
- A promising camptothecin derivative: Semisynthesis, antitumor activity and intestinal permeability. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY. 366-373. 2014
- Modified Non-Sink Equation for Permeability Estimation in Cell Monolayers: Comparison with Standard Methods . MOLECULAR PHARMACEUTICS. 1403-1414. 2014
- Tubulin acetylation promoting potency and absorption efficacy of deacetylase inhibitors (2). BRITISH JOURNAL OF PHARMACOLOGY. 1-12. 2014
- Validation of phenol red versus gravimetric method for water reabsorption correction and study of gender differences in Doluisio's absorption technique. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 105-110. 2014
- Variability of Permeability Estimation from Different Protocols of Subculture and Transport Experiments in Cell Monolayers.. JOURNAL OF PHARMACOLOGICAL AND TOXICOLOGICAL METHODS . 1-11. 2014
- Hydrogels: an interesting strategy for smart drug delivery.. THERAPEUTIC DELIVERY. 157-160. 2013
- Innovative in Vitro Method To Predict Rate and Extent of Drug Delivery to the Brain across the Blood-Brain Barrier . MOLECULAR PHARMACEUTICS. 3822-3831. 2013
- Ion-pair strategy for enabling amifostine oral absorption: Rat in situ and in vivo experiments. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 499-504. 2013
- Mathematical modeling of oral absorption and bioavailability of a fluoroquinolone after its precipitation in the gastrointestinal tract . XENOBIOTICA. 745-754. 2013
- Provisional classification and in silico study of biopharmaceutical system based on caco-2 cell permeability and dose number. MOLECULAR PHARMACEUTICS. 2445-2461. 2013
- Semisynthesis, Cytotoxic Activity, and Oral Availability of New Lipophilic 9-Substituted Camptothecin Derivatives. ACS MEDICINAL CHEMISTRY LETTERS. 86-90. 2013
- The Use of Rule-Based and QSPR Approaches in ADME Profiling: A Case Study on Caco-2 Permeability. MOLECULAR INFORMATICS. 459-479. 2013
- SPR in oral bioavailability: specificity or integrality?. MINI-REVIEWS IN MEDICINAL CHEMISTRY. 534-550. 2012
- A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies.. PHARMACEUTICAL STATISTICS. 1-37. 2011
- Assessment of fexofenadine hydrochloride permeability and dissolution with an anionic surfactant using Caco-2 cells.. PHARMAZIE. 747-753. 2011
- Improvement of effect of water-in-oil microemulsion as an oral delivery system for fexofenadine: in vitro and in vivo studies.. INTERNATIONAL JOURNAL OF NANOMEDICINE. 1631-1640. 2011
- In Silico Prediction of Caco-2 Cell Permeability by a Classification QSAR Approach. MOLECULAR INFORMATICS. 376-385. 2011
- In vitro-in situ permeability and dissolution of fexofenadine with kinetic modeling in the presence of sodium dodecyl sulfate.. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS. 1-21. 2011
- Influence of polyunsaturated fatty acids on Cortisol transport through MDCK and MDCK-MDR1 cells as blood-brain barrier in vitro model.. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 290-291. 2011
- A new mathematical approach for the estimation of the AUC and its variability under different experimental designs in preclinical studies. PHARMACEUTICAL STATISTICS. 0-37. 2010
- An Exploratory Study of Two Caco-2 Cell Models for Oral Absorption: A Report on Their Within-laboratory and Between-laboratory Variability, and Their Predictive Capacity. ATLA-ALTERNATIVES TO LABORATORY ANIMALS. 2010
- Computer simulations for bioequivalence trials (3): drugs with first-pass metabolism and two metabolic pathways. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 2010
- Drug penetration across the blood¿brain barrier: an overview. THERAPEUTIC DELIVERY. 535-562. 2010
- Unique pharmacology of Kar-2, a potential anti-cancer agent: absorption modelling and selective mitotic spindle targeting. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 11-19. 2009
- Biowaiver Monographs for Immediate Release Solid Oral Dosage Forms: Aciclovir . JOURNAL OF PHARMACEUTICAL SCIENCES. 5061-5073. 2008
- Computer simulations of bioequivalence trials: Selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Part II. Non-linear kinetics. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2008
- Computer simulations of bioequivalence trials: Selection of design and analyte in BCS drugs with first-pass hepatic metabolism: Linear kinetics (I). EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-10. 2008
- Progress in the development of early diagnosis and a drug with unique pharmacology to improve cancer therapy. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY A-MATHEMATICAL PHYSICAL AND. 1-19. 2008
- Unique pharmacology of KAR-2, a potential anti-cancer. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 1-12. 2008
- In situ kinetics modelling of intestinal efflux in rats: functional characterization of segmental diferences and correlation with in vitro results. BIOPHARMACEUTICS & DRUG DISPOSITION. 229-239. 2007
- Tecnologias para conocer la posibilidad de mejorar la biodisponibilidad oral. INDUSTRIA FARMACEUTICA. 58-64. 2007
- A topological Sub-structual Approach for the Prediction of P-Glycoprotein susbtrates. JOURNAL OF PHARMACEUTICAL SCIENCES. 589-606. 2006
- Estudios de biosimulación. FARMAESPAÑA INDUSTRIAL SOLUCIONES DE SOFTWARE. 46-49. 2006
- Kinetic modelling of passive transport and active efflux of a fluoquinolone across Caco-2 cells using a compartmental approach in NONMEM. XENOBIOTICA. 1067-1088. 2005
- Kinetic modelling of the intestinal transport of sarafloxacin. Studies in situ in rat and in vitro in Caco-2 cells. JOURNAL OF DRUG TARGETING. 199-212. 2005
- PAMPA a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones. EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES. 429-441. 2004
- A topological-substructural molecular design (TOPS-MODE) approach to determining pharmacokinetics and pharmacological properties of 6-fluoroquinolones derivatives. EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS. 197-206. 2003
chapter
- Importance and applications of cell-and tissue-based in vitro models for drug permeability screening in early stages of drug development. Concepts and models for drug permeability studies. 5-41. 2024
- In silico, in situ, in vitro, and in vivo predictive methods for modeling formulation performance.. From Current to Future Trends in Pharmaceutical Technology. 67-116. 2024
- In silico, in situ, in vitro and in vivo predictive methods for modelling formulation performance. From Current to Future Trends in Pharmaceutical Technology. 67-117. 2023
- In vitro ¿ in vivo correlation: General Concepts, Development and Advanced Approaches . CorrelaÇao in vitro in vivo no desenvolvimento de Medicamentos. 1-32. 2023
- Medicamentos genéricos ¿iguales a la marca de referencia?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 181-189. 2022
- Medicamentos vía oral: ¿con qué volumen de agua se deben administrar?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 247-256. 2022
- Nutracéuticos para cuidar la piel. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 115-128. 2022
- Seguridad en cosmética: cosmética natural e ingredientes controvertidos. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 129-140. 2022
- ¿Influyen los alimentos en el efecto de los medicamentos?. LO QUE DEBES SABER SOBRE MEDICAMENTOS Y SALUD. 257-270. 2022
- Differential absorption of curcuminoids between free and liposomed curcumin formularions. Curcumin. Clinical uses, health effects and potential complications. 99-111. 2016
- Absorción transdermica: Modelos in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 321-330. 2015
- Ajuste nolineal por mínimos cuadrados en Excel. Uso de herramienta Solver. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 539-567. 2015
- Cálculo depermeabilidad en rata: perfusión sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 499-504. 2015
- Cálculos de lapermeabilidad intestinal in vitro. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 482-489. 2015
- Cálculos denúmeros adimensionales. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 479-481. 2015
- Cálculos depermeabilidad en células de Franz. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 490-496. 2015
- Cálculos develocidad de disolución. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 505-538. 2015
- Cálculos en bioequivalencia. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 454-478. 2015
- Estudios de permeabilidad en humanos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 241-265. 2015
- Fundamentoscientíficos del BCS y de la Bioequivalencia in vitro: Aspectos teóricos. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 66-83. 2015
- Importance and applications of cell and tissue-based in vitro models for drug permeability screening in early stages of drug development. In:Concepts and models for drug permeability studies ¿ Cell and tissue-based in vitro culture models.. Woodhead Publishing Series in Biomedicine. 1-15. 2015
- Investigación animal para el desarrollo de nuevos fármacos: reducir, refinar o reemplazar.. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 166-182. 2015
- Perfusion in situ sin recirculación. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 349-359. 2015
- Permeabilidad en cultivos celulares. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 266-299. 2015
- Prediccion de la fraccion oral absorbida. Metodologías Biofarmacéuticas en el Desarrollo de Medicamentos. 45-65. 2015
- Drug Absorption. Encyclopedia of Pharmaceutical Science and Technology. Fourth Edition. Six Volume Set. 1-17. 2013
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-26. 2012
- Biosimulation Studies. Molecular BiopharmaceuticsAspects of Drug Characterisation, Drug Delivery and Dosage Form Evaluation. 314-363. 2011
- CORTISOL TRANSPORT ACROSS BIOLOGICAL BARRIERS. Cortisol: Physiology, Regulation and Health Implications. 1-25. 2011
- Caco-2 cells for studying Intestinal absorption mechanisims: comparison and correlation with rat model. Caco-2 cells and their uses. 129-163. 2011
- Computational and pharmacoinformatic approaches to oral bioavailability prediction. Oral Bioavailability: Basic principles, advances concepts and aplications. 519-535. 2011
- Computer Simulations as a Tool for Optimizing Bioequivalence Trials. Pharmacokinetics. 1-18. 2011
- VIRTUAL BIOEQUIVALENCE TRIALS AS ATOOL FOR REGULATORY DECISIONS. Mathematical modeling, clustering algorithms and applications. 165-178. 2010
- ASSESSMENT OF STUDENT¿S OWN PERCEPTION OF LEARNING. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5392-5397. 2009
- ASSESSMENT OF THE KNOWLEDGE OF PHDS AND MASTERSTUDENTS DURING THIS TRAINING PERIOD. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5358-5363. 2009
- COMPUTER AIDED LEARNING IN BIOPHARMACY. International technology, education and development conference. 2923-2926. 2009
- EDUCATIONAL STRATEGIES FOR THE INCREASING OF CREATIVITY. International technology, education and development conference. 2134-2137. 2009
- EVALUATION OF THE PHD STUDENTS¿ ENGLISH LEVEL. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5364-5370. 2009
- KNOWLEDGE ABOUT EHEA OF THE UNIVERSITARY STUDENTS . ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5870-5873. 2009
- PROGRAM PROPOSAL FOR EARLY CONTACT OF PREGRADUATE STUDENTS WITH THE RESEARCH WORLD: OR HOW TO MAKE THE RIGHT DECISION AT THE RIGHT TIME. International technology, education and development conference. 4692-4696. 2009
- TEAMWORK IN LABORATORY PRACTICES. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5968-5971. 2009
- TOWARDS THE EUROPEAN SPACE FOR HIGHER EDUCATION:QUALITY OF THE TUTORIALS. ICERI 2009. International Conference of Education, Research and Innovation. Proceedings. 5387-5390. 2009
- HOW AND WHERE ARE DRUGS ABSORBED?. Biosimulation in Drug Development. 249-280. 2008
- Correlation between in vitro, in situ and in vivo models. Biosimulation in Drug Development. 89-109. 2007
congress communication

presentations

invited conference
- Ensayos de solubilidad ICH para bioexención, Conferencia 2023
- Medios Biopredictivos. , Conferencia 2023
- Ensayos de disolución ICH para bioexención, Conferencia 2023
- An in vivo predictive dissolution methodology (iPD methodology) with a BCS Class IIb drug can predict the in vivo bioequivalence results: Etoricoxib products, Conferencia 2022
- Dissolution profile: modelation and comparison, Conferencia 2018
- IVIVC: definitions, levels and applications, Conferencia 2018
- Application of GI simulation to drug product development, Conferencia 2018
- Metodologías in vitro para el estudio de la permeabilidad, Conferencia 2012
- el modelado y la simulacion en experimentacion preclinica: ejemplos de aplicacion al proceso de absorcion intestinal, Conferencia 2009
- ADME: EXPERIMENTS AND MODELLING, Conferencia 2008
- Estudios Pk in vivo en animales, Conferencia 2008
- Estudios de permeabilidad in situ, Conferencia 2008
- Estudios de permeabilidad in vitro, Conferencia 2008
- Reducir, refinar, reemplazar en el desarrollo de medicamentos, Conferencia 2008
- Unique pharmacokinetics of kar-2 a potential anticancer agent, Conferencia 2007