Publicaciones en VIVO

Mapa de la ciencia

Red de Coinvestigador

DOMINGUEZ CASTELLANO, MARIA

Person (Active)

Positions

INVESTIGADOR CIENTIFICO CSIC, Instituto de Neurociencias 2003 -

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supported publications or other works

ADDRESSING THE COMPLEXITY OF NOTCH-INDUCED CANCER 2015
COOPERACION DE LA VIA DE SEÑALIZACION DE AKT Y NOTCH EN EL DESARROLLO DE TUMORES 2011
IDENTIFICACION DE GENES Y MECANISMOS CAUSATIVOS DE CANCER Y METASTASIS EN DROSOPHILA MELANOGASTER 2010
INTERACCIÓN ENTRE LAS VIAS DE NOTCH Y JAK/STAT, Y CARACTERIZACIÓN DE NUEVOS GENES EN EL CONTROL DE CRECIMIENTO Y CANCER EN DROSOPHILA MELANOGASTER 2007
MECHANISMS OF EPITHELIAL HOMEOSTASIS IN ADULT DROSOPHILA MIDGUT 2014
MOLECULAR MECHANISMS OF ONCOGENESIS MEDIATED BY THE BTB TRANSCRIPTION FACTOR PIPSQUEAK. IMPACT OF SUMOYLATION AND PROTEOLYTIC PROCESSING 2014
Nuevos mecanismos de cáncer y vía de señalización de NOTCH: silenciamiento epigenético y microRNAS 2008
ROLE OF PI3K/Akt/Pten IN TUMORIGENESIS: A LINK BETWEEN INFLAMMATION AND REPROGRAMMING OF THE HOST METABOLISM 2021
Role of PI3K/Akt/Pten in tumorigenesis: A link between inflammation and reprogramming of the host metabolism 2020
THE NEURAL CONTROL OF BODYSYMMETRY, AND AN AUTOMATED HIGH-RESOLUTION PUPAE COUNTING DEVICE 2023
THE NEUROENDOCRINE CONTROL OF ANIMAL SIZE, BODY PROPORTION AND SYMMETRY 2018

selected publications

academic article
- Metabolic Adaptations in Cancer and the Host Using Drosophila Models and Advanced Tools. CELLS. 1977-2003. 2024
- A blueprint for cancer related inflammation and host innate immunity. CELLS. 1-15. 2021
- Body-Fat Sensor Triggers Ribosome Maturation in the Steroidogenic Gland to Initiate Sexual Maturation in Drosophila. CELL REPORTS. 1-16. 2021
- Notch and EGFR regulate apoptosis in progenitorcells to ensure gut homeostasis in Drosophila. EMBO JOURNAL. 1-15. 2020
- Ecdysone-Induced 3D Chromatin Reorganization Involves Active Enhancers Bound by Pipsqueak and Polycomb. CELL REPORTS. 2715-2727. 2019
- Notch and EGFR regulate apoptosis in progenitor cells to ensure gut homeostasis in Drosophila. EMBO JOURNAL. 1-15. 2019
- One hundred years of Drosophila cancer research: no longer in solitude. DISEASE MODELS & MECHANISMS. 1-5. 2019
- Histone variant H2A.Z deposition and acetylation directs the canonical Notch signaling response. NUCLEIC ACIDS RESEARCH. 1-12. 2018
- PI3K/Akt Cooperates with Oncogenic Notch by Inducing Nitric Oxide-Dependent Inflammation. CELL REPORTS. 2541-2549. 2018
- Systemic signalling and local effectors in developmental stability, body symmetry, and size. CELL STRESS. 340-361. 2018
- Mesenchymal to epithelial transition during tissue homeostasis and regeneration - Patching up the Drosophila midgut epithelium.. FLY. 1-1. 2016
- A phospho-dependent mechanism involving NCoR and KMT2D controls a permissive chromatin state at Notch target genes. NUCLEIC ACIDS RESEARCH. 1-1. 2016
- A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. SCIENCE. 6262-6262. 2015
- Endocrine remodelling of the adult intestine sustains reproduction in Drosophila. ELIFE. 1-19. 2015
- Robust intestinal homeostasis relies on cellular plasticity in enteroblasts mediated by miR-8-Escargot switch. EMBO JOURNAL. 2025-2041. 2015
- acal is a Long Non-coding RNA in JNK Signaling in Epithelial Shape Changes during Drosophila Dorsal Closure.. PLOS GENETICS. 1-2. 2015
- Editorial. Cancer models in Drosophila.. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 62-62. 2014
- Oncogenic programmes and Notch activity: An `organized crime¿?. SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY. 78-85. 2014
- Chromatin-bound I¿B¿ is a modulator of PRC2-dependent repression in development and cancer. . CANCER CELL. 151-166. 2013
- Conserved miR-8/miR-200 Defines a Glial Niche that Controls Neuroepithelial Expansion and Neuroblast Transition.. DEVELOPMENTAL CELL. 174-187. 2013
- Dampening the signals transduced through hedgehog signal via microRNA miR-7 facilitates Notch-induced tumourigenesis.. PLOS BIOLOGY. 1-16. 2013
- Imaginal discs secrete insulin-like peptide 8 to mediate plasticity of growth and maturation time=Describimos una nueva molécula DILP8, nuevo miembro de la familia tipo-insulina en Drosophila con un papel fundamental en la regulación de la metamorfosis y proporción del tamaño del organismo final. SCIENCE. 579-582. 2013
- Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells:identificamos al microRNA miR8/200 como un inhibidor de la tumorogénesis y metástasis inducida por la sobreactivación de la vía de Notch. . EMBO JOURNAL. 756-769. 2013
- Genetic inactivation of the polycomb repressive complex 2 in T cell acute lymphoblastic leukemia. NATURE MEDICINE. 296-301. 2012
- Imaginal Discs Secrete Insulin-Like Peptide 8 to Mediate Plasticity of Growth and Maturation. SCIENCE. 579-582. 2012
- Targeting Notch signalling by the conserved miR-8/200 microRNA family in development and cancer cells.. EMBO JOURNAL. 756-769. 2011
- Mechanisms behind cancer metastasis: from Drosophila to humans and back. MECHANISMS OF DEVELOPMENT. 26-27. 2009
- The position and function of the Notch-mediated eye growth organizer: the roles of JAK/STAT and four-jointed. EMBO REPORTS. 1051-1058. 2009
- The role of the PTEN/AKT Pathway in NOTCH1- induced leukemia. CELL CYCLE. 965-970. 2008
- Mutational loss of PTEN induces resistance to NOTCH1 inhibition in T-cell leukemia. NATURE MEDICINE. 1203-1210. 2007
- Mutational loss of PTEN induces resistance to NOTCH1. Inhibition in T-ALL. BLOOD. 9-9. 2007
- Epigenetic silencers and Notch collaborate to promote malignant tumours by Rb silencing. NATURE. 430-436. 2006
- Interplay between Notch and epigenetic silencers in cancer. CANCER RESEARCH. 8931-8934. 2006
- The Organ Specification-Growth connection: new in-sights from the eye-antennal disc. DEVELOPMENTAL DYNAMICS. 673-684. 2005
- Growth and specification of the eye are controlled independently by eyegone and eyeless in Drosophila melanogaster. . NATURE GENETICS. 31-39. 2004
- Tufted is a Gain-of-Function Allele that Promotes Ectopic Expression of the Proneural Gene Amos in Drosophila. GENETICS. 1403-1412. 2003
- Tufted is a gain-of-function allele that promotes ectopic expression of the proneural gene amos in Drosophila. . GENETICS. 1403-1412. 2003
- Two-step process for photoreceptor formation in Drosophila. NATURE. 911-913. 2001
chapter
- Using Drosophila Models and Tools to Unsderstand the Mechanisms of Novel Human Cancer Driver Gene Function. The Drosophila Model in Cancer. 15-36. 2019
- In Depth Conversation: A brain circuit that synchronizes growth and maturation revealed through Dilp8 binding to Lgr3. Yearbook of Paediatric Endocrinology 2016. 236-239. 2016
congress communication

presentations

invited conference
- EDRC 2025 Meeting, Conferencia 2024
- EDRC 2025 Meeting, Conferencia 2024
- How do relaxin signalling and inter-organ communication drive developmental resilience and achieve perfect body symmetry?, Conferencia 2024
- Temporal disparities between sexes creates sexual conflict that contribute to the persistence of size variability, Conferencia 2024
- Triving Trough Time: Size Diversity, Gender, Resilience and Ageing, Conferencia 2023
- Obesity and the growth spurts, Conferencia 2022
- Amino acid-restriction in cancer: from friend to foe, Conferencia 2022
- Resilience, Conferencia 2022
- The very hungry caterpillar, Conferencia 2022
- SP 6: Genetic & epigenetic basis of Individuality & aging, Conferencia 2022
- Molecular bases of growth control and cancer in Drosophila, Conferencia 2021
- Body size and symmetry: ¿Why it is important and how it is achieved?", Conferencia 2021
- Charla Girls4STEM , Conferencia 2021
- Ayuno, fatiga, depresión, y cáncer: ¿Hay alguna conexión con la vía de PTEN/PI3K/AKT?, Conferencia 2021
- Somos 100tíficas, Conferencia 2020
- ¿Pueden las moscas con tumores diseñados `a la carta¿ acelerar el descubrimiento y reposicionamiento de medicamentos? , Conferencia 2019
- Signals that Regulate Inflammation and Systemic Metabolism in Notch/Pten-driven Tumors, Conferencia 2019
- Cáncer, de los mecanismos a la terapia., Conferencia 2019
- Immune escape of tumors relies on remote metabolic shift, Conferencia 2019
- Mesa redonda. `Presente y futuro de la investigación en cáncer. Motivos para la esperanza¿, Conferencia 2019
- Obesidad, masa corporal y madurez sexual: ¿cuál es el vínculo?, Conferencia 2019
- A body fat sensor in the prothoracic gland controls insect reproductive maturation, Conferencia 2018
- Mesa redonda de clausura: Mujer y Ciencia, Conferencia 2018
- Delta-Notch Signaling in the Adult Intestine: A Deathly Dialogue that Keeps Cell Numbers in Check, Conferencia 2018
- Dilp8/Lgr3A synchronizes brain-cicuit growth and maturation, Conferencia 2017
- Inflammation links PI3K/Akt and Notch in tumorigenesis, Conferencia 2017
- It's not the right time: How the brain resets the "growth"clock and delays maturation, Conferencia 2017
- Mechanisms of growth control and cancer in Drosophila, Conferencia 2017
- Cáncer, de los mecanismos a la terapia., Conferencia 2017
- Expect the unexpected! Unbiased high throughput screening in ¬ies can help to open unexpected doors for therapy in high-risk cancers., Conferencia 2016
- Mechanisms of growth control and cancer laboratory, Conferencia 2016
- Homeostatic size control or how the brain tries to smooth things over, Conferencia 2016
- A Drug Screen in a Drosophila Tumor Model Identifies Novel Anti-Cancer Drugs Effective in High-Risk Acute Lymphoblastic Leukemia, Conferencia 2016
- The invisible work of 'invisible' female scientists, Conferencia 2016
- Cancer & normal growth?, Conferencia 2016
- Epithelial-mesenchymal transition and its reverse programme via an Escargot-miR-8 switch mediates robust intestinal cell renewal, Conferencia 2015
- Addressing complexity of Notch in cancer: When less is more, Conferencia 2015
- Dra. María Domínguez, Conferencia 2015
- Simetría y proporción: insulin-like peptide 8 ¿la hormona de la belleza?, Conferencia 2014
- Drug-screening and phosphoproteomic analysis in a Drosophila Notch- , Conferencia 2014
- On-Demand Scaling: A Gut Feeling, Conferencia 2014
- Supply, demand, and adult tissue homeostasis, Conferencia 2014
- Deconstructing Tumour Metastasis en Drosophila , Conferencia 2013
- Antagonistic cooperation between Notch and Hedgehog signaling pathways in cancer, Conferencia 2013
- Cooperación antagonística entre las vías de Notch y de Hedgehog en cáncer, Conferencia 2013
- Mechanisms of growth control and cancer, Conferencia 2013
- (Ab)normal growing imaginal discs secrete DILP8 to adjust growth and maturation time to ensure normal size and symmetry, Conferencia 2012
- Growth Control and Cancer Laboratory, Conferencia 2012
- Society for Developmental Biology 71st Annual Meeting, Conferencia 2012
- Mechanisms of cellular specification in the Drosophila retina: the roles of Spalt proteins., Conferencia 2002
- Bases moleculares del desarrollo temprano del sistema visual. Conservación de Drosophila al hombre, Conferencia
- Control de crecimiento durante la formación del ojo: conservación de Drosophila al hombre, Conferencia
- Especificación y desarrollo del ojo en Drosophila, Conferencia
- Genetic dissection of the dorsal/ventral boundary in the Drosophila eye, Conferencia